Early Experience of Doxycycline Sclerotherapy for Lymphatic Malformations

Lee, Ju-Yeon; Namgoong, Jung‐Man; Kim, Seong Chul; Kim, Dae Yeon

doi:10.13029/aps.2019.25.2.44

Cited by 2 publications

(3 citation statements)

References 23 publications

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“…The total no. of sessions were ( 14) sessions for (7) patients , with a mean of 2 sessions for each patient ,(SD=1.5), (range 1-5)which coincided with shaye et al 2020 in which (10) ,that suggested that better result had been obtained when the injection volume was equal to the aspirated lymphatic fluid . [9], by doing this, each cyst became distended with the scleroting agent , for that in this study a ratio of 1:1 of (aspirated lymphatic fluid :doxycycline solution ) was maintained in macrocystic type and macrocystic part of combined type for the rest of all sessions of all patients in this study .…”

Section: ) Number Of Sessions Of the Patientssupporting

confidence: 76%

“…[13], Ju Yeon Lee et al2019 study in which ( 8) of ( 15) macrocystic LMs achieved complete resolution in average of (1.5) session. [14], which is higher in no. of sessions than this sample, on other hand the combined type in this sample seemed to require multiple sessions to achieve complete resolution which coincide with shaye et al 2020 who reported (5) sessions for patient with combined type to reach complete resolution .…”

Section: ) Number Of Sessions Of the Patientsmentioning

confidence: 78%

“…Ju Yeon Lee et al2019 encountered a skin necrosis only in (1) of ( 21) patients and considered as a rare complication , the necrosis was recovered by wound management . [14] ,Thomas et al reported superficial skin ulceration and then eschar in (1) of (32) patients . [8 ],in this sample no skin necrosis was encountered ,only a small eschar( 14.3%) corresponding to previous injection site , It is worth mentioning that the eschar was developed in…”

Section: ) Number Of Sessions Of the Patientsmentioning

confidence: 99%

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Doxycycline Sclerotherapy For Lymphatic Malformations Under Doppler Ultrasound Guide

2023

JPTCP

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Background: Lymphatic malformations are uncommon hamartomatous congenital malformations of lymphatic system that can manage by different percutaneous scleroting agents. Aim of study: This prospective study is to assess the effectiveness of doxycycline in all types of lymphatic malformations in terms of dose calculation and number of sessions and to evaluate risks versus benefits.Patients and method: one year period,(7) patients with simple Lymphatic malformations at the age (1-23) years were treated using doxycycline ( 10mg/ml ) as percutaneous intralesional scleroting agent guided by Doppler Ultra -sound, Magnetic resonance imaging was obtained in follow ups 6 weeks postoperatively . Results: there were (4) patients with macrocystic Lymphatic malformations (57.1%), (1) patient with microcystic Lymphatic malformations (14.3%) ,and (2) patients with combined Lymphatic malformations (28.6%) , there was complete resolution in( 6) patients (85.7%) including all types of Lymphatic malformations and residual lesion of (1) patient (14.3%) of combined type. All macrocystic type required only one session and the combined type required more sessions than other types, follow up range was (2-7) months after complete resolution. Conclusions: doxycycline is an effective, inexpensive, available scleroting agent that can achieve excellent result in all types of Lymphatic malformations with large doses even in small children with minor and manageable side effects.

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Section: ) Number Of Sessions Of the Patientssupporting

confidence: 76%

Section: ) Number Of Sessions Of the Patientsmentioning

confidence: 78%

Section: ) Number Of Sessions Of the Patientsmentioning

confidence: 99%

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Doxycycline Sclerotherapy For Lymphatic Malformations Under Doppler Ultrasound Guide

2023

JPTCP

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Comparison of intralesional bleomycin with/without doxycycline in the primary management of pediatric lymphangiomas

Pawar

Singh

Gupta

et al. 2021

Formosan Journal of Surgery

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Background: Although surgical excision is the treatment of choice for lymphangiomas, recently many centers are practicing intralesional sclerotherapy as the primary modality. The purpose of this study was to review the efficacy of intralesional Bleomycin, to study the efficacy of a combination of intralesional bleomycin and doxycycline and compare the results. Materials and Methods: In this clinical observational study, all patients were evaluated clinically and color Doppler ultrasonography. Patients were grouped into Group A, in which intralesional Bleomycin alone and Group B, in which a combination of intralesional Bleomycin and Doxycycline was instilled into the cysts. The clinical response was assessed and compared between the groups. Results: Out of 52 patients in the study, the most common site of lymphangioma was cervical 28 (53%) and the most common type was macrocystic lesion 44 (84.5%). In Group A, out of 26 patients, the response was excellent in 15 (58%), satisfactory in 8 (30%), and poor in 3 (12%). In Group B, out of 26 patients, the response was excellent in 22 (85%), satisfactory in 2 (7.5%), and poor in 2 (7.5%). The postprocedure complications were observed more in Group A than Group B, of which the most common was pain/tenderness in five patients followed by redness and fever. Conclusion: Intralesional bleomycin alone and a combination of intralesional bleomycin and Doxycycline injection both can be safe and effective sclerosant formulas for primary nonsurgical management. The use of combination of Bleomycin and Doxycycline required fewer treatment sessions to obtain clinical success compared to Bleomycin alone.

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Early Experience of Doxycycline Sclerotherapy for Lymphatic Malformations

Cited by 2 publications

References 23 publications

Doxycycline Sclerotherapy For Lymphatic Malformations Under Doppler Ultrasound Guide

Doxycycline Sclerotherapy For Lymphatic Malformations Under Doppler Ultrasound Guide

Comparison of intralesional bleomycin with/without doxycycline in the primary management of pediatric lymphangiomas

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