Early evaluation of survival of the transplanted ovaries through ultrasound molecular imaging <i>via</i> targeted nanobubbles

Zhang, Shan; Di, Na; Tayier, Baihetiya; Guan, Lina; Wang, Guodong; Lu, Hanbing; Yan, Fei; Mu, Yuming

doi:10.1039/d0bm01125h

Cited by 5 publications

(10 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Molecular probes are constructed by modifying antibodies or ligands of disease-specific molecules on the surface of biomaterials, and they constitute a noninvasive, effective and convenient detection technology that can achieve early detection and real-time monitoring of diseases at the molecular level [ 105 ]. Zhang et al developed AMH-targeted nanobubbles (NBAMH) by integrating AMH antibodies into the surface of nanobubbles (NBs) [ 105 ]. NBAMH showed high affinity for ovarian granulosa cells in vitro, and the ultrasound signal of transplanted ovaries was significantly enhanced compared to that of untargeted NBs.…”

Section: Biomaterials For the Evaluation Of Ovarian Agingmentioning

confidence: 99%

“…As shown in Fig. 4 , Zhang et al successfully prepared AMH-targeted nanobubbles, which exhibited a high affinity for ovarian granulosa cells in vitro and enhanced ultrasound signals in the ovaries [ 105 ]. This new method could be used for early follicle survival detection after ovarian transplantation.…”

Section: Biomaterials For the Evaluation Of Ovarian Agingmentioning

confidence: 99%

“…4 Schematic of AMH-targeted nanobubbles (NBAMH) and their targeting ability to rat ovarian granulosa cells expressing AMH. (the figure is reproduced from Zhang et al [ 105 ] with required copyright permission) …”

Section: Biomaterials For the Evaluation Of Ovarian Agingmentioning

confidence: 99%

See 2 more Smart Citations

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Guo

Wei

et al. 2022

J Nanobiotechnol

View full text Add to dashboard Cite

Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years, various strategies have been developed to preserve fertility in women, while there are currently no clinical treatments to delay ovarian aging. Recently, advances in biomaterials and technologies, such as three-dimensional (3D) printing and microfluidics for the encapsulation of follicles and nanoparticles as delivery systems for drugs, have shown potential to be translational strategies for ovarian aging. This review introduces the research progress on the mechanisms underlying ovarian aging, and summarizes the current state of biomaterials in the evaluation and treatment of ovarian aging, including safety, potential applications, future directions and difficulties in translation. Graphical Abstract

show abstract

Section: Biomaterials For the Evaluation Of Ovarian Agingmentioning

confidence: 99%

Section: Biomaterials For the Evaluation Of Ovarian Agingmentioning

confidence: 99%

See 1 more Smart Citation

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Guo

Wei

et al. 2022

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…In order to monitor the survival of ovarian cells in the early transplantation, MU et al developed AMH-targeted TABLE 1 | The production of gas vesicles (GVs) from engineered bacteria in ultrasound imaging (Bourdeau et al, 2018;Huang et al, 2019). (Jiang et al, 2015;Yang et al, 2016;Cai et al, 2018;Peng et al, 2019;Wu et al, 2019;Fang et al, 2020;Jiang et al, 2020;Zhang et al, 2020). nanobubbles by integrating an AMH antibody onto the surface of NBs.…”

Section: Monitoring Treatment Responsementioning

confidence: 99%

Nanosized Contrast Agents in Ultrasound Molecular Imaging

Zeng

Chen

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Applying nanosized ultrasound contrast agents (nUCAs) in molecular imaging has received considerable attention. nUCAs have been instrumental in ultrasound molecular imaging to enhance sensitivity, identification, and quantification. nUCAs can achieve high performance in molecular imaging, which was influenced by synthetic formulations and size. This review presents an overview of nUCAs from different synthetic formulations with a discussion on imaging and detection technology. Then we also review the progress of nUCAs in preclinical application and highlight the recent challenges of nUCAs.

show abstract

“…2,3 Ultrasound contrast agent (UCA) can significantly enhance ultrasound signals, its application enhances its role in cancer diagnosis and treatment. [4][5][6][7] At present, the most concerned ultrasound contrast agent is the microbubble composed of an outer shell and an inner gas, with a diameter of 1$8 lm. 8 The advantages of microbubbles contrast agents are as follows: On the one hand, bubbles have a strong scattering effect on ultrasonic waves, which can enhance tissue echo and improve the clarity and resolution of imaging, which is clinically approved.…”

Section: Introductionmentioning

confidence: 99%

Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging

Wang

Ding

et al. 2021

J Biomater Appl

View full text Add to dashboard Cite

In this experiment, a new amphiphilic chitosan-poly(lactide) graft copolymer was synthesized and characterized by IR, 1H-NMR, XRD, TGA. The obtained chitosan-poly (lactide) graft copolymer was used as the matrix material to prepare nanodroplets (NDs) encapsulating with liquid PFP by double-emulsion and solvent evaporation method. The resulting NDs were characterized by photon correlation spectroscopy and transmission electron microscopy (TEM). The biocompatibility was explored by cytotoxicity assay, cell migration assay and blood biochemistry analysis. The experiments of ultrasonic imaging in vitro and in vivo were carried out with a B-mode clinical ultrasound imaging system. The results of FI-IR and 1H-NMR confirmed the successful grafting reaction of polylactic acid(PLLA) to chitosan with a graft rate of 365%. The average size of the NDs was 101.1 ± 2.7 nm, with the polydispersity index (PDI) of 0.127 ± 0.020, and the zeta potential was −31.8 ± 1.5 mV. From the TEM results, NDs were highly dispersed and had a spherical shape with a distinct capsule structure. The NDs exhibited good stability during storage at 4°C. The NDs solution with different concentrations did not affect cell growth and showed good biocompatibility in cytotoxicity, cell migration and blood biochemistry studies. Under the irradiation of ultrasonic waves, the NDs formed an ultrasonic high signal, which could significantly enhance the ultrasound imaging of tumor tissue in vivo. Taken together, the NDs hold great potential for ultrasound imaging as a nanosized contrast agent.

show abstract

Early evaluation of survival of the transplanted ovaries through ultrasound molecular imaging via targeted nanobubbles

Abstract: Ovarian survival after transplantation is key to determining the success and efficacy of ovarian tissue cryopreservation and transplantation (OTCP). However, non-invasive monitoring of ovarian survival in the early stages of...

Cited by 5 publications

References 40 publications

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Nanosized Contrast Agents in Ultrasound Molecular Imaging

Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging

Contact Info

Product

Resources

About