Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Wu, Meng; Guo, Yican; Wei, Simin; Xue, Liru; Tang, Weicheng; Chen, Dan; Xiong, Jiaqiang; Huang, Yibao; Fu, Fangfang; Wu, Chuqing; Chen, Ying; Zhou, Shanshan; Zhang, Jinjin; Li, Yan; Wang, Wenwen; Dai, Jun; Wang, Shixuan

doi:10.1186/s12951-022-01566-8

Cited by 11 publications

(7 citation statements)

References 321 publications

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“…Biomaterials take the advantages of promoting cell interactions, excellent stability and biodegradability, good passive and active targeting and show great potential in various applications including regenerative medicine ( 184 ). Su et al.…”

Section: Enhancing the Effect Of Bmscsmentioning

confidence: 99%

Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects

Huang

Zhu²,

Liu³

et al. 2022

Front. Immunol.

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Premature ovarian failure (POF) is a common female reproductive disorder and characterized by menopause, increased gonadotropin levels and estrogen deficiency before the age of 40 years old. The etiologies and pathogenesis of POF are not fully clear. At present, hormone replacement therapy (HRT) is the main treatment options for POF. It helps to ameliorate perimenopausal symptoms and related health risks, but can’t restore ovarian function and fertility fundamentally. With the development of regenerative medicine, bone marrow mesenchymal stem cells (BMSCs) have shown great potential for the recovery of ovarian function and fertility based on the advantages of abundant sources, high capacity for self-renewal and differentiation, low immunogenicity and less ethical considerations. This systematic review aims to summarize the possible therapeutic mechanisms of BMSCs for POF. A detailed search strategy of preclinical studies and clinical trials on BMSCs and POF was performed on PubMed, MEDLINE, Web of Science and Embase database. A total of 21 studies were included in this review. Although the standardization of BMSCs need more explorations, there is no doubt that BMSCs transplantation may represent a prospective therapy for POF. It is hope to provide a theoretical basis for further research and treatment for POF.

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Section: Enhancing the Effect Of Bmscsmentioning

confidence: 99%

Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects

Huang

Zhu²,

Liu³

et al. 2022

Front. Immunol.

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“…In collagen hydrogels of 3 mg/mL and 5 mg/mL, the survival rate of ovarian follicles was over 90% (90 ± 4% and 98 ± 2%, respectively). Alterations in collagen hydrogel density and elasticity resulted in variations in follicle growth and development, sex hormone production, and oocyte maturation, emphasizing the importance of physical properties in the maintenance of the phenotype and function of follicles in 3D culture systems [ 37 ].…”

Section: Applications Of 3d Printing Technology In Obstetrics and Gyn...mentioning

confidence: 99%

3D Printing and Its Current Status of Application in Obstetrics and Gynecological Diseases

Zhang

2023

Bioengineering

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3D printing technology is a novel method of utilizing computer-generated three-dimensional models for drawing, assembling special bioinks, and manufacturing artificial organs and biomedical products. In recent years, it has evolved into a relatively mature therapeutic approach and has been widely used in clinical and basic research. In the field of obstetrics and gynecology, 3D printing technology has been applied for various purposes, including disease diagnosis, treatment, pathogenesis research, and medical education. Notably, researchers have gained significant application experience in common gynecological and obstetrical disorders, such as intrauterine adhesions, uterine tumors, congenital malformations, and fetal congenital abnormalities. This review aims to provide a systematical summary of current research on the application of 3D bioprinting technology in the field of obstetrics and gynecology.

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“…Drug delivery via NPs should be effective in postponing ovarian aging. In fact, studies are currently being pursued to use them in both 3D cultures and tissue engineering, with the purpose of increasing cell proliferation and viability [ 109 ].…”

Section: The Benefits Of Nanotechnologiesmentioning

confidence: 99%

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

Aloisi

Rossi

Colafarina

et al. 2022

IJERPH

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Humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and our bodily systems are well adapted to protect us from these potentially harmful external agents. However, technological advancement has dramatically increased the production of nanometer-sized particles or nanoparticles (NPs), and many epidemiological studies have confirmed a correlation between NP exposure and the onset of cardiovascular diseases and various cancers. Among the adverse effects on human health, in recent years, potential hazards of nanomaterials on female reproductive organs have received increasing concern. Several animal and human studies have shown that NPs can translocate to the ovary, uterus, and placenta, thus negatively impacting female reproductive potential and fetal health. However, NPs are increasingly being used for therapeutic purposes as tools capable of modifying the natural history of degenerative diseases. Here we briefly summarize the toxic effects of few but widely diffused NPs on female fertility and also the use of nanotechnologies as a new molecular approach for either specific pathological conditions, such as ovarian cancer and infertility, or the cryopreservation of gametes and embryos.

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Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Cited by 11 publications

References 321 publications

Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects

Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects

3D Printing and Its Current Status of Application in Obstetrics and Gynecological Diseases

The Impact of Metal Nanoparticles on Female Reproductive System: Risks and Opportunities

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