Early Enteral Feeding in Postsurgical Cancer Patients

Abstract

Early enteral feeding with FOSL-HN was safe and well tolerated. Results suggest that the use of such a formula during the postoperative period may reduce the number of infections and gastrointestinal complications per patient, as well as improve renal and liver function through modulation of urinary prostaglandin levels. Additional clinical trials to fully quantify clinical benefits and optimize nutritional support with FOSL-HN should be undertaken.

Perioperative Nutrition in Elective Gastrointestinal Surgery – Potential for Improvement?

“…They alter the formation of prostaglandin E 2 to prostaglandin E 3 , which has a less immunosuppressive effect [82]. The use of these fatty acids has been reported to decrease the total number of gastrointestinal and infectious complications and improve postoperative liver and kidney function through modulation of tissue prostaglandin levels [83, 84]. …”

Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients

“…Nutritional support after injury may modulate the immune, inflammatory, and metabolic responses, and the clinical outcome of critically ill subjects. In different experimental and clinical settings, enteral vs parenteral route, early vs delayed enteral feeding, and immuneenhancing enteral vs standard diets are related to better results [1][2][3] . Supplementation of enteral diets with glutamine, arginine and ω-3 fatty acids has been reported to improve clinical outcome after major operations and to reduce the risk of septic complications above and beyond the role of standard enteral formula [4] .…”

“…However, there was no trend toward significance between the supplemented and standard diet groups on the d8 after operation, and it was an unexpected finding. Many of the immunosuppressive effects of the ω-6 fatty acids are found to be related to the immunosupp ressive prostaglandins, particularly PGE 2 . It has been shown in previous studies that increasing the ratio ω-3 fatty acids in the diet effectively alters the monocyte/macrophage lipid membrane, decreasing the production of PGE 2 .…”

Effect of a Fish Oil–Containing Beverage on Changes in Plasma Lipid Fatty Acids in Patients With Malabsorption

“…Even though well-tolerated in anorectic subjects, perhaps providing much smaller amounts of supplement as the active agent only would have been better tolerated. Use of fish oil-structured lipids as the source of fish oil might also be more effective [21] and should be investigated. In fish oil-structured lipids, the EPA or DHA can be located specifically in the sn-2 position of the triglyceride, rather than randomly as is the case in the triglyceride in the fish oil-containing beverage that we used.…”