Early dynamic 201Tl SPECT in the evaluation of brain tumours

Sugo, Nobuo; Yokota, Kyosuke; Kondo, Kousuke; Harada, Naoyuki; Aoki, Yosuke; Miyazaki, Chikao; Nemoto, Minoru; Kano, Toshiyuki; Ohishi, Hitoshi; Seiki, Yoshikatsu

doi:10.1097/01.mnm.0000191853.34574.3f

Cited by 11 publications

(13 citation statements)

References 17 publications

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“…Tl SPECT is a functional imaging technique that facilitates diagnosis of tumor malignancy and activity [14]. An early Tl SPECT image mainly shows tumor blood flow, and a delayed image mainly shows tumor malignancy and activity [15]. The Tl SPECT findings in our patient were comparable to those of patients with benign meningioma showing high blood flow and low malignancy.…”

supporting

confidence: 62%

Intradiploic Meningioma in the Lateral Orbital Wall: A Case Report

Shibata¹,

Osuka²,

Matsumura³

2012

J Cancer Ther Res

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Orbital wall tumor and intradiploic meningioma are rare tumors. Magnetic resonance imaging and nuclear medicine findings in the cases of orbital intradiploic meningioma have rarely been reported. A 46-year-old man presented with gradually appearing exophthalmos. MR and nuclear medicine findings revealed intradiploic tumor on the lateral orbital wall. The patient underwent total tumor resection and final pathological diagnosis was benign meningioma. This case highlights the importance of pathological conformation before performing extensive surgery. Thallium single-photon emission computed tomography is a valuable technique for distinguishing intradiploic benign meningioma from other malignant tumors.

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supporting

confidence: 62%

Intradiploic Meningioma in the Lateral Orbital Wall: A Case Report

Shibata¹,

Osuka²,

Matsumura³

2012

J Cancer Ther Res

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“…Tedeschi et al found the early temporal pattern of T1-201 concentration in intracranial meningiomas is probably related to their biologic aggressiveness, 11 and Sugo et al suggested that dynamic 201 TlCl SPECT was useful in distinguishing malignant brain tumors from benign tumors. 23 Our current study revealed 13 N-NH 3 was unable to differentiate grade I from grade II meningiomas. Unlike 13 N-NH 3 , F-18 FDG accumulated more in the grade II meningiomas than in the grade I tumors, and F-18 FDG is a more accurate reflection of tumor grade than is 13 N-NH 3 uptake.…”

Section: Discussionmentioning

confidence: 64%

13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma

Zhang

Xingchong

Chen

et al. 2011

Clinical Nuclear Medicine

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“…2,3 Dynamic Tl SPECT is useful in evaluating tumor vascularity, histology and malignancy. 14,15 However, this technique can produce false positive and false negative results. 6,7,12,16,17 Inflammation after surgery or radiation is a major cause of false positive Tl uptake.…”

Section: Tl Spectmentioning

confidence: 96%

Direct comparison of thallium-201 and technetium-99m MIBI SPECT of a glioma by receiver operating characteristic analysis

Shibata

Yamamoto

Takano

et al. 2009

Journal of Clinical Neuroscience

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The diagnostic value of single photon-emission computed tomography (SPECT) has been assessed using arbitrarily determined sensitivity and specificity cut-off values. The diagnostic accuracy of thallium-201 (Tl-201) SPECT and technetium-99m methoxyisobutylisonitrile (Tc-MIBI) SPECT were compared for patients with primary glioma using receiver operating characteristic (ROC) analysis. The study population included 59 patients with gliomas. Tl and Tc-MIBI SPECT images were obtained using a multi-detector SPECT machine 15 min (early) and 3 hours (delayed) after intravenous injection of 74 MBq of Tl-chloride or 740 MBq of Tc-MIBI. The regions of interest were set on the tumor and contralateral normal white matter and tumor : normal ratios were calculated. The area z-score (A(z)) values were calculated from the areas under the ROC curves. All A(z) values were high and no statistical difference was observed between the two modalities. Both Tl and Tc-MIBI SPECT are useful imaging modalities for the evaluation of glioma malignancy.

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Early dynamic 201Tl SPECT in the evaluation of brain tumours

Abstract: We suggest that the performance of 201Tl dynamic SPECT for 15 min is useful for distinguishing malignant brain tumours from benign brain tumours and reduces the examination stress of patients.

Cited by 11 publications

References 17 publications

Intradiploic Meningioma in the Lateral Orbital Wall: A Case Report

Intradiploic Meningioma in the Lateral Orbital Wall: A Case Report

13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma

Direct comparison of thallium-201 and technetium-99m MIBI SPECT of a glioma by receiver operating characteristic analysis

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