Early diastolic functional abnormalities in normotensive offspring of Nigerian hypertensives

Adeoye, Abiodun M.; Adebiyi, Adewole A; Oladapo, Olulola O; Ogah, Okechukwu S; Aje, Akinyemi; Ojji, Dike; Adebayo, Adedeji K; Ochulor, Kenneth C; Enakpene, Evbu; Falase, A. O.

doi:10.5830/cvja-2011-030

Cited by 7 publications

(9 citation statements)

References 36 publications

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“…Thus, the heart does more work in pushing blood against the thickened arterial wall leading to an increase in arterial blood pressure. 44,51 However, our study did not show any signi cant gender difference in the occurrence of hypertension although a systematic review on the current prevalence and pattern of hypertension in Nigeria reported higher prevalence of hypertension among males compared to females 44,45,52,53 . Being employed and having dyslipidaemia were other predictors of hypertension in this study.…”

Section: Discussioncontrasting

confidence: 80%

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Prevalence of Non-Communicable Diseases and its Risk Factors among Ijegun-Isheri Osun Residents in Lagos State, Nigeria: A Community Based Cross-Sectional Study

Idris

Oguntade

Mensah³

et al. 2020

Preprint

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Background: The rapid epidemiologic transition of diseases has adverse implications for low-and middle-income countries (LMICs) like Nigeria due to their limited healthcare, weaker health systems and the westernization of lifestyle. There is a need to evaluate the enormity or otherwise of non-communicable diseases (NCDs) burden in such low resource settings. We performed this survey to determine the prevalence of NCDs and its risk factors among the Ijegun- Isheri Osun community residents of Lagos, Nigeria.Methods: A community-based cross-sectional survey was performed on 215 respondents recruited consecutively during a population preventive health campaign. Prevalence of three NCDs (hypertension, diabetes and dyslipidaemia) were calculated. Associations between each of these NCDs and selected risk factors were determined using chi square test. Multivariable logistic regression was used to estimate the risk factors of each of the three NCDs.Results: The prevalence of hypertension was 35.3% (95%CI 29.0-42.1), diabetes 4.6% (95%CI 2.2-8.4) and dyslipidaemia 47.1% (95%CI 41.1-54.8). Among the NCD risk factors, the prevalence of smoking was 41.3% (95%CI 34.2-48.6), alcohol consumption 72.5% (95% CI 65.5-78.7), and physical activity 52.9 (95%CI 45.5-60.2). The independent significant predictors of hypertension were age ≥60 years (aOR 4.56; 95%CI: 1.72-12.09) and dyslipidaemia (aOR 5.01; 95%CI: 2.26-11.13). Age ≥60 years (aOR 8.83; 95%CI: 1.88-41.55) was an independent predictor of diabetes. Age ≥60 years (aOR 29.32; 95%CI: 4.78-179.84), being employed (aOR 11.12; 95%CI: 3.10-39.92), smoking (aOR 2.34; 95%CI: 1.03-5.33) and physical activity (aOR 0.34; 95%CI: 0.15-0.76) were independent predictors of having dyslipidaemia.Conclusions: The prevalence of hypertension, diabetes and dyslipidaemia and their associated risk factors are high among the respondents of Ijegun-Isheri Osun community of Lagos state, Nigeria. This highlights the need for further implementation research and policy directions to tackle NCD burden in urban communities in Nigeria. These strategies must be community specific, prioritizing the various risk factors and addressing them accordingly.

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Section: Discussioncontrasting

confidence: 80%

“…However, lower prevalence of physical activity (37.8%) among civil servants in Ibadan have been reported. 44,45 The differences in the ndings could be due to the subjective method of assessment in self-reported questionnaires. 46 Meanwhile, this study used WHO recommendation to classify participants into physical activity categories.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Non-Communicable Diseases and its Risk Factors among Ijegun-Isheri Osun Residents in Lagos State, Nigeria: A Community Based Cross-Sectional Study

Idris

Oguntade

Mensah³

et al. 2020

Preprint

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“…Moreover, Lagos is a boisterous city and residents have to engage in demanding jobs and travel long distance daily in search of their daily means of sustenance. However, lower prevalence of physical activity (37.8%) among civil servants in Ibadan have been reported [40,41]. The differences in the findings could be due to the subjective method of assessment in self-reported questionnaires [42].…”

Section: Discussionmentioning

confidence: 90%

Prevalence of non-communicable diseases and its risk factors among Ijegun-Isheri Osun residents in Lagos State, Nigeria: a community based cross-sectional study

et al. 2020

View full text Add to dashboard Cite

Background: The rapid epidemiologic transition of diseases has adverse implications for low-and middle-income countries (LMICs) like Nigeria due to their limited healthcare, weaker health systems and the westernization of lifestyle. There is a need to evaluate the enormity or otherwise of non-communicable diseases (NCDs) burden in such low resource settings. We performed this survey to determine the prevalence of NCDs and its risk factors among the Ijegun-Isheri Osun community residents of Lagos, Nigeria. Methods: A community-based cross-sectional survey was performed on 215 respondents recruited consecutively during a population preventive health campaign. Prevalence of three NCDs (hypertension, diabetes and dyslipidaemia) were calculated. Associations between each of these NCDs and selected risk factors were determined using chi square test. Multivariable logistic regression was used to estimate the risk factors of each of the three NCDs. Results: The prevalence of hypertension was 35.3% (95% CI 29.0-42.1), diabetes 4.6% (95% CI 2.2-8.4) and dyslipidaemia 47.1% (95% CI 41.1-54.8). Among the NCD risk factors, the prevalence of smoking was 41.3% (95% CI 34.2-48.6), alcohol consumption 72.5% (95% CI 65.5-78.7), and physical activity 52.9 (95% CI 45.5-60.2). The independent significant predictors of hypertension were age ≥ 60 years (aOR 4.56; 95% CI: 1.72-12.09) and dyslipidaemia (aOR 5.01; 95% CI: 2.26-11.13). Age ≥ 60 years (aOR 8.83; 95% CI: 1.88-41.55) was an independent predictor of diabetes. Age ≥ 60 years (aOR 29.32; 95% CI: 4.78-179.84), being employed (aOR 11.12; 95% CI: 3.10-39.92), smoking (aOR 2.34; 95% CI: 1.03-5.33) and physical activity (aOR 0.34; 95% CI: 0.15-0.76) were independent predictors of having dyslipidaemia. Conclusions: The prevalence of hypertension, diabetes and dyslipidaemia and their associated risk factors are high among the respondents of Ijegun-Isheri Osun community of Lagos state, Nigeria. This highlights the need for further implementation research and policy directions to tackle NCD burden in urban communities in Nigeria. These strategies must be community specific, prioritizing the various risk factors and addressing them accordingly.

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“…In a study by Dupont et al ., spontaneously hypertensive rats (SHR) demonstrated early LV diastolic dysfunction before the onset of hypertension and LV hypertrophy (LVH) (Dupont et al ., ). A Nigerian study on normotensive offspring of hypertensive parents revealed that diastolic dysfunction precedes clinical hypertension in genetically predisposed individuals, without evidence of LVH (Adeoye et al ., ).…”

Section: The Hypertension Linkmentioning

confidence: 97%

Myocardial energetics and ubiquinol in diastolic heart failure

Bates

Shen

Hiebert

et al. 2014

Nursing & Health Sciences

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Diastolic heart failure, or heart failure with preserved ejection fraction, is a leading cause of morbidity and mortality. There are no current therapies effective in improving outcomes for these patients. The aim of this article is to review the literature and examine the role of coenzyme Q10 in heart failure with preserved ejection fraction related to mitochondrial synthesis of adenosine triphosphate and reactive oxygen species production. The study results reflect that myocardial energetics alters in diastolic heart failure and that there is defective energy metabolism and increased oxidative stress. Studies are emerging to evaluate coenzyme Q10 , particularly ubiquinol, as a supplemental treatment for heart-failure patients. In diastolic heart-failure patients, clinicians are beginning to use supplemental therapies to improve patient outcomes, and one promising complementary treatment to improve left ventricular diastolic function is ubiquinol. Additional studies are needed using large-scale randomized models to confirm if ubiquinol would be beneficial. Since ubiquinol is an antioxidant and is required for adenosine triphosphate production, clinicians and health scientists should be aware of the potential role of this supplement in the treatment of diastolic heart failure.

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Early diastolic functional abnormalities in normotensive offspring of Nigerian hypertensives

Cited by 7 publications

References 36 publications

Prevalence of Non-Communicable Diseases and its Risk Factors among Ijegun-Isheri Osun Residents in Lagos State, Nigeria: A Community Based Cross-Sectional Study

Prevalence of Non-Communicable Diseases and its Risk Factors among Ijegun-Isheri Osun Residents in Lagos State, Nigeria: A Community Based Cross-Sectional Study

Prevalence of non-communicable diseases and its risk factors among Ijegun-Isheri Osun residents in Lagos State, Nigeria: a community based cross-sectional study

Myocardial energetics and ubiquinol in diastolic heart failure

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