Early Diagnosis of Familial Type II Hyperlipoproteinemia

Greten, H.; Wengeler, H; Wagner, H

doi:10.1159/000175430

Cited by 18 publications

(9 citation statements)

References 1 publication

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“…For instance, in Bogalusa the mean level of total cholesterol was 70 mg/dl while the range reported by others was from 60-82 mg/dl (7, 8 12-16, 21). For triglycerides, the average level in Bogalusa was 40 mg/dl as compared to published mean values ranging from 32-42 mg/dl (7,12,(14)(15)(16)21). Cord blood lipoprotein levels have not been studied extensively but their characterization is obviously important.…”

Section: Discussionmentioning

confidence: 63%

“…Numerous studies have focused on the utility of cord blood as a screening mechanism for identifying neonatal type I1 hyperlipoproteinemias (8,13,15,16,21,23,29,31). Familial hypercholesterolemia (monogenic inheritance, 0.4 % of all births (29) can be identified at birth if one or more parents exhibits the trait (21, 3 1).…”

Section: Discussionmentioning

confidence: 99%

“…Several investigators have reported that cord blood cholesterol levels appear to have little relation to levels at 1 year of age (8,16,23), whereas others suggest the evidence is far from conclusive (21,29,31). Kwiterovich (20) feels that cord blood P-lipoprotein cholesterol (or low density lipoprotein cholesterol) has greater diagnostic power of subsequent hyperlipidemia than total cholesterol due to the prominent contribution made to cord blood cholesterol by a-lipoproteins.…”

Section: Discussionmentioning

confidence: 99%

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Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study

Frerichs¹,

Srinivasan

Webber

et al. 1978

Pediatr Res

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SummaryThe lipid profile, total cholesterol, triglycerides, and lipoproteins (P-, pre-/I-, and a-) of cord blood, is presented for 419 black and ~h i t e infants (9.1% of the eligible population) born during an 18-month period in Bogalusa, Louisiana. At birth, white neonates of both seses had higher average levels than black neonates of total cholesterol and /I-lipoproteins. White girls among the four races e s groups had the highest cord blood levels of total cholesterol, /I-lipoproteins, and a-lipoproteins. Neither stress at delivery. birthweight, socioeconomic status, nor season of the year had an observable effect on any of the lipid or lipoprotein levels. The magnitude and direction-of the relationships between the respective lipids and lipoproteins in cord blood were similar to those we have observed in preschool and school-aged children in the same community. Total cholesterol was highly correlated with both /Iand a-lipoproteins; triglycerides were correlated with pre-/I-lipoproteins but inversely with a-lipoproteins. These observations suggest that basic biochemical relationships are already established at birth.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study

Frerichs¹,

Srinivasan

Webber

et al. 1978

Pediatr Res

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“…Since the appearance of the first reports of hypercholesterolaemia in newborns of known hypercholesterolaemic parents (27,28,29), interest has been focused on population studies of newborns with the aim of early detection of atherogenic hyperlipidaemia ( I , 2, 4,5,7, 12,14,15,17,19,20,21,32,34,37). In large population studies on newborns, familial hypercholesterolaemia would seem to be detectable (1,2,7,19,20,21). It is more doubtful whether familial hypertriglyceridaemia can be detected at birth, but in one investigation hypertriglyceridaemia of familial origin was discovered by analysis of cord blood (37).…”

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confidence: 99%

Serum Lipids and Lipoproteins at Birth Based on a Study of 2815 Newborn Infants

Hardell¹

1981

Acta Paediatrica

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Abstract. In a consecutive series of 2 815 newborn infants the triglyceride (TG) and cholesterol (CHOL) concentrations were determined in total cord serum and in high density lipoprotein (HDL) containing serum after precipitation of very low (VLDL) and low density lipo proteins (LDL) with heparin manganese chloride. The serum concentrations of TG and CHOL in VLDL+LDL were calculated as the differences between the concentrations in total serum and HDL. The serum concentration of TG totally, in VLDL+LDL and HDL were 0.48, 0.33 and 0.14 mmol/l, respectively, in boys and 0.47, 0.32 and 0.15 mmol/l in girls and of CHOL 1.75, 0.94 and 0.80 mmol/l in boys and 1.88, 1.00 and 0.87 mmol/l in girls. The concentrations of CHOL were significantly higher (p<0.001) in girls than in boys. The distributions of all lipid parameters were skewed to the right, that is towards higher values. Lipoprotein electrophoresis in agarose gel was performed on all serum samples. Patterns compatible with hyperbeta and/or hyperprebeta lipoproteinaemia were observed but no cbylomicrons, broad beta, late prebeta or sinking prebeta lipoprotein bands. The skew distributions of TG and CHOL may be due to primary of secondary hyperlipidaemias.

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“…The conflicting results with regard to correlation between cord total or VLDL-LDL-cholesterol and total cholesterol at one to two years of age within populations (2,4,5,7,8,18,21,23,24) could be due to differing environmental pressure on infants after birth. Newborns with a high total or VLDL-LDL-cholesterol could be more vulnerable to a diet rich in cholesterol.…”

Section: Vldl-ldl-cholesterol At Birth and Future Lipoproteins 783mentioning

confidence: 99%

Does VLDL‐LDL‐Cholesterol in Cord Serum Predict Future Level of Lipoproteins?

Fønnebø

Dahl²,

Pj³

et al. 1991

Acta Paediatrica

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Lipoproteins were measured in 618 healthy, full-term newborns. Seventy-four with a VLDL-LDL-cholesterol above 1.3 mmol/l (50 mg/dl) at birth and 25 randomly chosen controls with VLDL-LDL-cholesterol 1.3 mmol/l or below at birth were followed up at age 2. Seventy-two (52 in the high VLDL-LDL-cholesterol group and 20 in the low VLDL-LDL-cholesterol group) were followed up at age 13. At age 2 mean total cholesterol was 5.48 mmol/l (SEM 0.10) in the children with a high VLDL-LDL-cholesterol at birth, compared to 4.69 mmol/l (SEM 0.17) in the children with a low VLDL-LDL-cholesterol at birth (p less than 0.001). A difference was still present at age 13 (4.74 mmol/l; SEM 0.11 versus 4.20 mmol/l; SEM 0.14; p less than 0.01). At age 13 apolipoprotein B was 0.74 g/l (SEM 0.02) in the children with a high VLDL-LDL-cholesterol at birth, compared to 0.65 g/l (SEM 0.02) in the children with a low VLDL-LDL-cholesterol at birth (p less than 0.01). Children with high VLDL-LDL-cholesterol at birth might be more liable to high lipoprotein serum levels later in life.

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Early Diagnosis of Familial Type II Hyperlipoproteinemia

Cited by 18 publications

References 1 publication

Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study

Serum Lipids and Lipoproteins at Birth in a Biracial Population: The Bogalusa Heart Study

Serum Lipids and Lipoproteins at Birth Based on a Study of 2815 Newborn Infants

Does VLDL‐LDL‐Cholesterol in Cord Serum Predict Future Level of Lipoproteins?

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