Early Diabetes Induces Changes in Mitochondrial Physiology of Inner Retinal Neurons

Haider, Syeda Zehra; Sadanandan, Nidish P.; Joshi, Preeti G.; Mehta, Bhupesh

doi:10.1016/j.neuroscience.2019.02.026

Cited by 20 publications

(9 citation statements)

References 40 publications

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“…Retinal neurons cultured in high glucose exhibit increased mitochondrial calcium load, associated with depolarization of mitochondrial membrane and ROS generation. Similar observations were made in retinas from 9-week-old diabetic rats [ 191 ].…”

Section: Consequences Of Increased Oxidative Stress In the Neural supporting

confidence: 85%

Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease

2020

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Diabetic retinopathy (DR), a common chronic complication of diabetes mellitus and the leading cause of vision loss in the working-age population, is clinically defined as a microvascular disease that involves damage of the retinal capillaries with secondary visual impairment. While its clinical diagnosis is based on vascular pathology, DR is associated with early abnormalities in the electroretinogram, indicating alterations of the neural retina and impaired visual signaling. The pathogenesis of DR is complex and likely involves the simultaneous dysregulation of multiple metabolic and signaling pathways through the retinal neurovascular unit. There is evidence that microvascular disease in DR is caused in part by altered energetic metabolism in the neural retina and specifically from signals originating in the photoreceptors. In this review, we discuss the main pathogenic mechanisms that link alterations in neural retina bioenergetics with vascular regression in DR. We focus specifically on the recent developments related to alterations in mitochondrial metabolism including energetic substrate selection, mitochondrial function, oxidation-reduction (redox) imbalance, and oxidative stress, and critically discuss the mechanisms of these changes and their consequences on retinal function. We also acknowledge implications for emerging therapeutic approaches and future research directions to find novel mitochondria-targeted therapeutic strategies to correct bioenergetics in diabetes. We conclude that retinal bioenergetics is affected in the early stages of diabetes with consequences beyond changes in ATP content, and that maintaining mitochondrial integrity may alleviate retinal disease.

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Section: Consequences Of Increased Oxidative Stress In the Neural supporting

confidence: 85%

Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease

2020

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“…These commonly differentially expressed genes and pathways might be involved in the regulation of the pathogenic mechanisms of DN as well as the therapeutic response of ZY alone or metformin þ ZY in the protection of blood glucose, metabolism, and renal injury in DN. Studies have shown that both spontaneous type 1 diabetes and type 2 diabetes model rats show neurological synaptic degeneration and neuronal decline (Nakano et al 2016;Haider et al 2019). The cAMP pathway also plays a regulatory role in multiple tissues, including in diabetes, and is closely related to the renal fibrosis of diabetic nephropathy (Bockus and Humphries 2015;Arcaro et al 2018;Huang et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“… 2016 ; Haider et al. 2019 ). The cAMP pathway also plays a regulatory role in multiple tissues, including in diabetes, and is closely related to the renal fibrosis of diabetic nephropathy (Bockus and Humphries 2015 ; Arcaro et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats

Liu

Shuai

et al. 2020

Pharmaceutical Biology

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“…The capability of the inward mitochondrial layer depolarizes as opposed to hyperpolarization. Mitochondrial depolarization in STZ-diabetes can be forestalled by controlling low-portion insulin or NT-3 [49,50].…”

Section: Mitochondrial Depolarization In Diabetesmentioning

confidence: 99%

“…In creature models of type 1 diabetes found unmyelinated little neuron cell misfortune however there is no data of apoptosis or variations from the norm in mitochondrial structure in DRG. Be that as it may, morphology and axonal development are upset by high glucose because of high oxidative pressure which brings about axonal degeneration [49,50].…”

Section: Mitochondrial Depolarization In Diabetesmentioning

confidence: 99%

Calcium Dyshomeostasis in Neuropathy Diabetes

Kurniawan¹

2020

Weight Management

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Diabetes is a ceaseless ailment that is basic in practically all nations. Neuropathy is the most well-known constant difficulty of diabetes and is the underlying reason for ulceration in the legs of lower appendage removals. The predominance of diabetic polyneuropathy shifts from 23 to 29%. Incessant metabolic pressure incited by hyperglycemia, either low insulin creation in type 1 diabetes or diminished fringe affectability to insulin in type 2 diabetes influences cell homeostasis in practically all phone types. Changes in the sign Ca 2+ have been recognized in different seclusion tissues from creatures initiated to diabetes just as patients with diabetes. Ca 2+ homeostasis variations from the norm have likewise been found in an assortment of tissues, including bone, heart and smooth muscle, secretory cells, platelets, kidneys and osteoblasts. This variation from the norm by and large shows as an expanded resting centralization of intracellular Ca 2+ ([Ca 2+ ]I), diminished Ca 2+ transporter movement and diminished boost that produces Ca 2+ signals. Ca 2+ flagging issue are likewise found in neuron-sensory from trial creatures with diabetes.

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Early Diabetes Induces Changes in Mitochondrial Physiology of Inner Retinal Neurons

Cited by 20 publications

References 40 publications

Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease

Diabetic Retinopathy: The Role of Mitochondria in the Neural Retina and Microvascular Disease

Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats

Calcium Dyshomeostasis in Neuropathy Diabetes

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