Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats

Liu, Xuemei; Liu, Deliang; Shuai, Youyou; Li, Hui-Lin; Zhao, Hengxia; Qu, Xin; Chu, Shufang; Zhang, Xuewen

doi:10.1080/13880209.2020.1844242

Cited by 6 publications

(7 citation statements)

References 23 publications

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“…Chen WP ( 65 ) demonstrated that Danhong Huayu Koufuye combined with metformin had a preventive and therapeutic effect on diabetic retinopathy by alleviating hyperglycaemia, reducing oxidative stress and improving lipid metabolism. Liu X ( 66 ) concluded that Huoxue Jiangtang decoction combined with metformin could significantly lower blood glucose and serum cholesterol levels and exerted protective effects on kidney tissue damage. Lian F ( 67 ) showed that Jinlida combined with metformin significantly improved β-cell function compared to metformin monotherapy.…”

Section: Discussionmentioning

confidence: 99%

The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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Section: Discussionmentioning

confidence: 99%

The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis

et al. 2022

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“…In previous studies, we found that HJD has a good therapeutic effect on metabolic diseases [ 25 – 27 , 29 , 30 ], and have improved the preparation process of TCM placebo which had been applied for a patent [ 46 ], providing a corresponding clinical basis for this study. Therefore, we designed this study to further evaluate the effect of HJD Elixation and Formula Granules in treating prediabetes, the results may also discover the effect of HJD in oral LA threshold, dietary preference, saliva and intestinal microbiota of prediabetes patients, thus to further explain its potential therapy mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have proved that HJD has the effects of regulating glucose and lipid metabolism, improving inflammation and oxidative stress state, and improving insulin resistance, with good therapeutic effects on type 2 diabetes, metabolic syndrome, and diabetic nephropathy, etc. [ 25 , 29 , 30 ] The dosage of HJD Formula Granules and HJD Elixation is determined by the long-term clinical application experience of our hospital.…”

Section: Methodsmentioning

confidence: 99%

Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol

Zhang

Zeng

Meng

et al. 2022

BMC Complement Med Ther

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Background Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, tumors, dementia, and other diseases in the future when compared to the healthy population. However, prediabetes is mainly treated based on lifestyle intervention, currently without targeted drug treatment plan. Traditional Chinese medicine (TCM), which has a longstanding experience, has been shown in clinical studies to be effective for the treatment of diabetes and its related complications. Furthermore, different dosage forms such as decoction and granule have developed gradually in clinical application. Preliminary studies have found that Huoxue-Jangtang Decoction (HJD), with good hypoglycemic and lipid-regulating effects, is potentially one of the complementary and alternative treatments for prediabetes. Therefore, this project intends to perform a prospective clinical study to observe the clinical effectiveness of HJD on prediabetes and the consistency of the efficacy of formula granules and the elixation. Methods This is a prospective, randomized, double-blind, and placebo-controlled clinical trial. A total of 183 participants are randomly assigned to HJD Formula Granules plus lifestyle intervention, HJD Elixation plus lifestyle intervention, and placebo plus lifestyle intervention. All subjects undergo 1 day of screening before participating in the study, followed by 84 days of drug intervention and observation. During and after treatment, the main outcome measures include fasting blood glucose and 2-hour postprandial blood glucose. Discussion This research attempts to verify the clinical efficacy and possible mechanism of HJD in the treatment of prediabetes, and prove the consistency of HJD Formula Granules with HJD Elixation. This study also aims to provide a treatment that is both effective and safe for prediabetic patients. Trial registration ClinicalTrials.gov Identifier: ChiCTR2200060813, Registered 12 June 2022.

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“… 47 A previous study has confirmed that decreasing taste sensitivity for fat in obese population is likely to be relevant with the alteration of salivary environment. 19 Shetty et al proposed that decreasing perception of PROP was closely related to higher abundance of Streptococcus in saliva. 48 The results of this study reveal that preferences for fat and sugar are significantly positively correlated with the abundance of Streptococcus in diabetic rats, indicating that diabetes possibly alters preferences for fat and sugar by changing oral microbial colony.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, HJD proved to improve the metabolism of glucose and lipid. 19 Furthermore, it was found that Hydroxysafflor Yellow A, one of the main active components of HJD, 20 could reduce the level of fasting blood glucose and IR, and suppress the apoptosis of β-cell. 21 Even so, more studies exploring the mechanisms of anti-diabetic effects of HJD need to be conducted due to the features of multi-route and multi-target of formulas in TCM.…”

Section: Introductionmentioning

confidence: 99%

Huoxue Jiangtang Decoction Alleviates Type 2 Diabetes Mellitus by Regulating the Oral Microbiota and Food Preferences

Huang¹,

Meng²,

Li³

et al. 2022

DMSO

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Purpose As a formula of traditional Chinese medicine (TCM), Huoxue Jiangtang Decoction (HJD) has positive effects on diabetes mellitus (DM) through improving of the metabolism of glycolipid and the function of β-cell. Hence, this research aims to explore the potential therapeutic effects of HJD on diabetes and reveal its underlying mechanisms. Methods Diabetic rat models induced by high-fat diet (HFD) and streptozotocin (STZ) were included in this study. Following successful modeling, diabetic rats were treated with HJD, and then its therapeutic effects in eight weeks were evaluated. In addition to biochemical indicators, two-bottle preference tests were carried out to examine the rats’ preferences for fat and sugar, and 16S rRNA gene sequencing was performed to disclose the differences of oral microbiota among groups. Finally, Pearson correlation coefficient was used to explore the correlation between oral microbiota and the preferences for fat and sugar. Results It was found that HJD significantly improved the levels of fasting blood glucose (FBG), glucose tolerance, and dyslipidemia. Additionally, HJD contributed to decreasing preferences for fat and sugar in diabetic rats, which plays an important role in food intake. Furthermore, HJD regulated the abundance, distribution, and structure of oral microbiota in diabetic rats, serving as one of the underlying mechanisms of its antidiabetic effects. Conclusion Taken with other formulas, HJD functions to improve the metabolism of glycolipid and the function of β-cell by inhibiting preferences for fat and sugar, as well as regulating the oral microbiota of diabetic rats. Furthermore, a potential correlation between the oral micro-environment and preferences for fat and sugar in STZ-induced diabetic rats is likely to exist.

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Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats

Cited by 6 publications

References 23 publications

The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis

The effect of Chinese herbal formulas combined with metformin on modulating the gut microbiota in the amelioration of type 2 diabetes mellitus: A systematic review and meta-analysis

Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol

Huoxue Jiangtang Decoction Alleviates Type 2 Diabetes Mellitus by Regulating the Oral Microbiota and Food Preferences

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