Early diabetes: a five year follow-up of diabetes in an English community

Walker, Joan B.; Brown, Parker

doi:10.1097/00006199-196501420-00099

Cited by 3 publications

(3 citation statements)

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“…O'Sullivan and Hurwitz [13] observed that 27% of young women with grossly abnormal glucose tolerance tests reverted to normal glucose tolerance. A similar degree of variability of diagnoses within several years has previously been described [1,15,18], but, for several reasons, these studies cannot be compared directly with the results given in this report.…”

Section: Discussionsupporting

confidence: 71%

Follow-up of ?non-diabetic? relatives of diabetics by retesting oral glucose tolerance after 5 years

1975

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Summary. Of 743 first degree relatives of diabetics in whom oral glucose tolerance tests had been performed in 1967 488 were re-tested in 1972. Among the original "normals" (n= 353) 17.6% had developed a "subclinical" and 1.3% an "overt diabetes" within 5 years. The original "subclinical diabetics" (n=l18) showed a remission to "normal" in 35,6% and a progression to "overt diabetes" in 13.6%. 3 out of the 17 formerly "overt diabetics" were found to be "normal" after 5 years and 3 were "subclinical diabetics". Thus the performance of an oral glucose tolerance test is of limited prognostic value in the individual case. In both studies a higher prevalence of abnormal test results occurred in the older age groups and in overweight subjects. Remission or ,deterioration did not depend, however, on age or on weight changes. The frequency of abnormal tests was higher in males than in females, but the tendency towards the development of diabetes was more pronounced in females, in accordance with a previous observation of a higher age dependance of glucose tolerance in females.

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Section: Discussionsupporting

confidence: 71%

Follow-up of ?non-diabetic? relatives of diabetics by retesting oral glucose tolerance after 5 years

1975

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“…Could this “spontaneous” improvement have come because, informed of their IGT, the persons changed diet and lifestyle? In fact, correction of lifestyle and obesity has been shown to improve GT, 14 and screening was useful in preventing evolution of IGT to DM in high‐risk populations 32,33 . Sartor et al 34 found that of patients with IGT left untreated, 29% eventually became diabetic.…”

Section: Discussionmentioning

confidence: 99%

A Longitudinal Study of Impaired Glucose Tolerance and Diabetes Mellitus in the Aged

Grobin¹

1989

J American Geriatrics Society

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“…The majority of subjects with IGT do not show unequivocal evidence of diabetes mellitus, within five years or even 8-10 years later [9][10][11][12], although they do have an increased risk of decompensation to clinical diabetes [13] and are perhaps more prone to atherosclerosis e.g. coronary heart disease, than those with unequivocally normal post-load glucose levels [14,15].…”

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confidence: 99%

Fasting and two-hour post-load glucose levels for the diagnosis of diabetes

Rushforth

Miller

Bennett³

1979

Diabetologia

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The frequency distributions of both the fasting and two-hour post-load plasma glucose levels were bimodal in the Pima Indian population aged 25 years and over. The hyperglycaemic component of this distribution represents those with diabetes mellitus, as some 30 percent of this group had evidence of the specific vascular complications of the disease, whereas these abnormalities were virtually absent in those with lower glucose levels. The bimodal characteristics of the frequency distributions were utilized to define optimal criteria to separate those with and without diabetes. The sensitivity and specificity of these criteria for fasting and two-hour glucose levels were compared and were found to be similar. The fasting glucose determination, however, was more reproducible and stable, as well as being easier to obtain, indicating that it is the better measurement for diagnostic purposes. The optimal level for diagnosis of 7.5 mmol/l (136 mg/dl) for the fasting glucose and the equivalent two-hour value of 14 mmol/l (250 mg/dl), were higher than many previously recommended diagnostic levels. Nevertheless, there was no evidence that subjects with lower levels were at appreciable risk of developing the specific complications of diabetes. Subjects with impaired glucose tolerance (IGT), but without fasting hyperglycaemia, should not be diagnosed as having diabetes mellitus.

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Early diabetes: a five year follow-up of diabetes in an English community

Cited by 3 publications

References 0 publications

Follow-up of ?non-diabetic? relatives of diabetics by retesting oral glucose tolerance after 5 years

Follow-up of ?non-diabetic? relatives of diabetics by retesting oral glucose tolerance after 5 years

A Longitudinal Study of Impaired Glucose Tolerance and Diabetes Mellitus in the Aged

Fasting and two-hour post-load glucose levels for the diagnosis of diabetes

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