Early developmental onset of alkaloid biosynthesis in Mexican poppy (Argemone mexicana L) Papaveraceae

Xool-Tamayo, Jorge; Monforte‐González, Miriam; Rubio-Piña, Jorge; Mirón-López, Gumersindo; Vázquez‐Flota, Felipe

doi:10.1016/j.phytol.2016.12.020

Cited by 7 publications

(27 citation statements)

References 18 publications

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“…The presence of jatrorrhizine could not be confirmed with these experiments, probably due to the low sensitivity of RMN, so further work on the isolation of the chromatographic peak that produces this signal will be made. These results agree with previous phytochemical investigations that revealed the presence of several alkaloids [ 11 ], including berberine, jatrorrhizine, protopine, allocryptopine, and sanguinarine. In addition, the plant produces more than 25 benzylisoquinoline alkaloids [ 25 ].…”

Section: Resultssupporting

confidence: 93%

“…Various types of chemical constituents are present in this plant, although alkaloids are the most abundant [ 10 ]. In traditional medicine, different parts of this plant are used to treat chronic skin diseases, ulcers, asthma, and other intestinal conditions [ 11 – 13 ]. Studies have shown that the extracts of A. mexicana and some of its individual components are effective against bacteria, fungi, viruses, nematodes, and parasites [ 14 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Study of Antiamoebic Activity of Methanol Extracts ofArgemone mexicanaon Trophozoites ofEntamoeba histolyticaHM1-IMSS

Elizondo-Luévano

Castro‐Ríos

Sánchez

et al. 2018

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Infections caused by parasites in humans represent one of the main public health concerns. Amoebiasis, a parasitic infection caused by Entamoeba histolytica (E. histolytica), is considered endemic in Mexico, where Argemone mexicana (A. mexicana) has been used in traditional medicine to treat intestinal parasitic diseases. The objective of this work was to evaluate the potential biological activity of A. mexicana on E. histolytica. For this purpose, a methanolic extract was prepared from A. mexicana leaves, and a differential fractionation was carried out with solvents of different polarities. The inhibitory capacities of the extract and its fractions were evaluated in vitro using HM1-IMSS, a strain of Entamoeba histolytica. A. mexicana extract was found to have a growth-inhibiting activity for E. histolytica, showing IC50 = 78.39 μg/mL. The extract was characterized phytochemically, and the methanolic extract fractions were analyzed by liquid chromatography (HPLC) and mass spectrometry (MS). Berberine and jatrorrhizine were present in the active fractions, and these compounds may be responsible for the antiparasitic activity. The identification of amoebicidal activity of A. mexicana on E. histolytica gives support to the traditional use. Further studies with berberine and jatrorrhizine will be carried out to understand the mechanism involved.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

In Vitro Study of Antiamoebic Activity of Methanol Extracts ofArgemone mexicanaon Trophozoites ofEntamoeba histolyticaHM1-IMSS

Elizondo-Luévano

Castro‐Ríos

Sánchez

et al. 2018

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…1(C)). These values are among the usually reported 0.6 and 1.0 mg gDW -1 ) for Argemone seeds [7]. Since no berberine was observed, it was not further monitored in the mature seeds.…”

Section: Resultsmentioning

confidence: 57%

“…Although these observations point to a possible sanguinarine role in the chemical defense of the actual seed structures, rather than to the soil adverse microflora during seedling unfolding, liberation of sanguinarine has been observed from Argemone radicles tips during this process [7]. Hence, alkaloid contents were analysed at the early stages of hypocotyl emergence (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In Papaver somniferum (Papaveraceae), the benzylisoquinoline alkaloid morphine is found in the capsular fruits but not in seeds, which seems related to the absence of laticifer cells where the alkaloid is accumulated [6]. Argemone mexicana L., the Mexican prickly poppy, is another member of the Papaveraceae family which accumulates berberine throughout the complete plant, except in mature seeds, and sanguinarine exclusively in roots and seeds even when biosynthetic activity could be detected in stems and leaves [7,8]. Argemone seeds are contained in septicidal capsules with four to six locules.…”

Section: Introductionmentioning

confidence: 99%

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Alkaloid Distribution in Seeds of Argemone mexicana L. (Papaveraceae)

et al. 2021

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Abstract. Seeds of Argemone mexicana L. accumulate significative amounts of sanguinarine. The analysis of the distribution of this alkaloid through the tissues of mature seeds revealed that up to 60 % of its contents was found tightly fixed to the different components of the seed external covers where it persisted during seedling germination. Contrastingly, sanguinarine contents in cotyledon accounted for the remaining 40 % and it could have been, at least partially, mobilized to the newly formed hypocotyls during emergence from seeds. Berberine was only detected in immature seeds and in seedlings once cotyledons were totally displayed. These results are discussed as a possible sanguinarine role in the chemical protection during seedlings germination. Resumen. Semillas de Argemone mexicana L. acumulan cantidades elevadas de sanguinarina. Un análisis de la distribución de alcaloides en los diferentes tejidos que componen la semilla reveló que hasta un 60 % del contenido se encontraba fuertemente unido en las capas que forman la cubierta exterior, donde se retuvieron durante la emergencia del hipocótilo. En contraste, los cotiledones presentaron el 40 % restante y parte de ello pudo haber sido movilizado al hipocótilo al emerger. Berberina sólo se observó en semillas inmaduras y en plántulas en desarrollo con los cotiledones desplegados. Estos resultados se discuten en función del posible papel defensivo de la sanguinarina durante la germinación.

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AmABCB1, an alkaloid transporter from seeds of Argemone mexicana L (Papaveraceae)

Loza-Müller

Shitan

Yamada

et al. 2021

Planta

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Early developmental onset of alkaloid biosynthesis in Mexican poppy (Argemone mexicana L) Papaveraceae

Cited by 7 publications

References 18 publications

In Vitro Study of Antiamoebic Activity of Methanol Extracts ofArgemone mexicanaon Trophozoites ofEntamoeba histolyticaHM1-IMSS

In Vitro Study of Antiamoebic Activity of Methanol Extracts ofArgemone mexicanaon Trophozoites ofEntamoeba histolyticaHM1-IMSS

Alkaloid Distribution in Seeds of Argemone mexicana L. (Papaveraceae)

AmABCB1, an alkaloid transporter from seeds of Argemone mexicana L (Papaveraceae)

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