AmABCB1, an alkaloid transporter from seeds of Argemone mexicana L (Papaveraceae)

Loza-Müller, Lloyd; Shitan, Nobukazu; Yamada, Yasuyuki; Vázquez‐Flota, Felipe

doi:10.1007/s00425-021-03780-4

Cited by 1 publication

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EcABCB1 was preferentially expressed in the roots of E. californica, which is the major site of accumulation for this alkaloid [24]. Interestingly, AmABCB1 from A. mexicana was reported mainly to be expressed in seeds with an important expression also observed in roots and in very low levels in leaves [25]. The specific role that sanguinarine could have in seeds of A. mexicana is unknown but it is suggested that it might act as a defense against herbivores due to its high toxicity.…”

Section: Tissue Distribution and Regulationmentioning

confidence: 99%

An Update of the Sanguinarine and Benzophenanthridine Alkaloids’ Biosynthesis and Their Applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

Benzophenanthridines belong to the benzylisoquinolic alkaloids, representing one of the main groups of this class. These alkaloids include over 120 different compounds, mostly in plants from the Fumariaceae, Papaveraceae, and Rutaceae families, which confer chemical protection against pathogens and herbivores. Industrial uses of BZD include the production of environmentally friendly agrochemicals and livestock food supplements. However, although mainly considered toxic compounds, plants bearing them have been used in traditional medicine and their medical applications as antimicrobials, antiprotozoals, and cytotoxic agents have been envisioned. The biosynthetic pathways for some BZD have been established in different species, allowing for the isolation of the genes and enzymes involved. This knowledge has resulted in a better understanding of the process controlling their synthesis and an opening of the gates towards their exploitation by applying modern biotechnological approaches, such as synthetic biology. This review presents the new advances on BDZ biosynthesis and physiological roles. Industrial applications, mainly with pharmacological approaches, are also revised.

show abstract

Section: Tissue Distribution and Regulationmentioning

confidence: 99%