Early development of immune system in pigs

Sinkora, J; Rehakova, Zuzana; Šinkora, Marek; Cukrowská, Božena; Tlaskalová‐Hogenová, Helena

doi:10.1016/s0165-2427(02)00056-9

Cited by 52 publications

(55 citation statements)

References 17 publications

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“…However, pigs, together with all other ungulates, were speculated for .30 y to belong to species that use ileal Peyer's patches for development of B cells (10,11,25). We have previously shown that ileal Peyer's patches are not required for B cell development and maintenance (12)(13)(14), and that this role has probably been filled by the BM (26)(27)(28)(29)(30). In the present study we have finally shown that B cell lymphogenesis in pigs clearly occurs in the BM.…”

Section: Discussionsupporting

confidence: 59%

“…In any case, the expression of CD2 and CD25 molecules occurs almost simultaneously in the mouse pre-B cell stage just after HC rearrangement (3,32), which is compatible with our results. However, although porcine B cells are always CD25 + , mature B cells may express CD2 differentially (12,17,18,20,(26)(27)(28)33). This fluctuation of CD2 expression is probably a reason why CD2 and CD25 are not always expressed mutually inclusive and why early B cell precursors (subsets 1-3) cannot be unambiguously identified by CD2/CD25 expression (Fig.…”

Section: Discussionmentioning

confidence: 99%

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B Cell Lymphogenesis in Swine Is Located in the Bone Marrow

Šinkora

Šinkorová

2014

The Journal of Immunology

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A course and a site of B cell development in swine are not firmly known. In this study, we show that B cell lymphogenesis is located in the bone marrow (BM). According to expression of MHC class II (MHC-II), CD2, CD21, CD25, CD45RC, CD172a, swine workshop cluster (identification number) (SWC) 7, and μHC, porcine BM cells were resolved into seven subsets representing sequential stages of development. Profile of rearrangement-specific products and transcripts from sorted BM cells confirmed the proposed developmental pathway. The same developmental pathway was further proven by analysis of selection for productive rearrangements in Ig H chains and also by cultivation studies. Cultivation also showed that earliest precursors with incomplete DJ rearrangements can still revert their B cell differentiation and develop along myeloid lineage, whereas this is impossible for later developmental stages. Proliferation and the apoptotic potential of individual developmental stages as well as critical checkpoints were also identified. Colocalization experiments showed early colocalization of MHC-II/CD2/CD172a is replaced by colocalization of MHC-II/CD2/CD21/SWC7/IgM in immature cells, whereas CD25 and CD45RC did not colocalize with any other studied molecules. In this study, we also finally prove that the BM in pigs is fully functional in adult animals and that B lymphogenesis occurs there throughout life. To our knowledge, this is the first study showing a course and a direct site of B cell lymphogenesis in swine.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

B Cell Lymphogenesis in Swine Is Located in the Bone Marrow

Šinkora

Šinkorová

2014

The Journal of Immunology

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“…As a result of pigs having an epitheliochorial placenta, fetal pigs continue their growth in a completely germ-free environment. This situation provides great ease and benefits in various ways while examining the steps of immune system development in newly born piglets (10). Nevertheless, studies on lymphocyte biology in pigs are mostly conducted with lymphoid organs obtained from pigs that have reached the age of slaughter (11).…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure of apoptotic T lymphocytes and thymicepithelial cells in early postnatal pig thymus

Ceylan¹,

Alabay²

2017

Turk J Vet Anim Sci

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The thymus is a primary lymphoid organ that provides the microenvironment required for the development of T lymphocytes. Thymic epithelial cells (TECs) are among the most critical components in the thymic microenvironment supporting thymocyte selection and maturation. Apoptosis is primarily a physiologic process that plays a major role during the development of T lymphocytes. The first purpose of this study was to examine morphological changes in apoptotic thymocytes by transmission electron microscope in piglets. The second purpose was to reveal the morphological typology of TECs in piglets. Tissue samples of the thymus were taken from healthy Yorkshire race pigs of two different age groups (7 days and 1 month). Ultrastructurally, apoptotic lymphocytes showed similar morphologies, but they also had differences in distribution. In both groups a high density of apoptotic and proliferating thymocytes was found in the cortex. The rate of apoptotic thymocytes in the cortex and medulla increased with age, respectively. It was observed that the TECs had various morphological subtypes in both the cortex and the medulla. A similar cellular distribution pattern of TECs was seen in both groups. It was concluded that the morphological diversity in the TECs may be related to the form-function relationship and the metabolic process.

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“…En réponse à cette question, il apparaît que les foetus peuvent produire in utero des IgGs et des IgMs suite à une stimulation d'antigène in utero et, spontanément, des cellules B productrices d'immunoglobulines ont été isolées des foetus du porcelet (Rooke et Bland, 2002). De plus, les composants du système immunitaire du foetus du porcelet sont en place immédiatement avant la mise-bas et ce foetus peut synthétiser des IgG suite à la réponse à l'attaque d'un antigène in utero (Sinkora et al, 2002 (Simister et Rees, 1985). Deux types de récepteurs néonataux existent chez les mammifères, le récepteur acide-dépendant et le récepteur acideindépendant.…”

Section: Transfert De L'immunité Colostrale Au Porcelet Nouveau-né Trunclassified

Physiologie de l’immunité colostrale chez les porcins et facteurs de variation du rendement et de la qualité immunitaire du colostrum de la truie

Agbokounou¹,

Ahounou²,

Karim³

et al. 2017

Int. J. Bio. Chem. Sci

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RESUMEChez les porcins comme chez d'autres mammifères, le colostrum apporte des substances nutritives et des facteurs immunitaires pour compenser l'immunité non transmise avant la naissance et le déficit énergétique avec lequel naissent les porcelets. Le colostrum est alors un aliment déterminant dans la survie du porcelet pendant les premières heures de sa vie et par conséquent un facteur important de la productivité de la truie. Le mécanisme de sa synthèse et du transfert de l'immunité au nouveau-né est complexe et mérite d'être bien cerné en vue d'assurer la survie du porcelet. La présente revue a non seulement décrit les mécanismes de synthèse des composants immunitaires et de leur transfert au nouveau-né, mais a fait aussi l'état des lieux de récents travaux sur les facteurs influençant la quantité et la qualité immunitaire du colostrum chez la truie. L'accent a été alors mis sur la composition du colostrum, la synthèse des composés nutritifs et immunitaires (transfert des immunoglobulines du sang dans la glande mammaire et leur synthèse locale), le transfert des immunoglobulines et des cellules immunitaires au porcelet et les facteurs endogènes et exogènes influençant la quantité et la qualité immunitaire du colostrum de la truie. © 2017 International Formulae Group. All rights reserved.Mots clés : Colostrum, immunité, espèce porcine, immunoglobuline.A. M. AGBOKOUNOU et al. / Int. J. Biol. Chem. Sci. 11(1): 420-443, 2017 421 Physiology of colostral immunity and factors influencing yield and immune quality of sow colostrum ABSTRACTIn pigs as in other mammals, colostrum provides nutrients and immune factors to compensate the nontransmitted immunity before birth and the energy deficit with which piglets are born. Colostrum intake is then crucial for piglet survival during the first hours of life and therefore for sows productivity. The mechanism of its synthesis and immunity transfer to the newborn is complex and deserves to be well defined in order to ensure piglet survival. This review describes the synthesis mechanisms of immune components and their transfer to the newborn. It also provides an update of recent research on the factors influencing the quantity and immune quality of colostrum in sows. Emphasis was then placed on the colostrum composition, synthesis of nutrients and immune compounds (transfer of blood immunoglobulins in the mammary gland and their local synthesis), the transfer of immunoglobulins and immune cells in the piglet and endogenous and exogenous factors affecting the quantity and immune quality of colostrum from the sow.

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Early development of immune system in pigs

Cited by 52 publications

References 17 publications

B Cell Lymphogenesis in Swine Is Located in the Bone Marrow

B Cell Lymphogenesis in Swine Is Located in the Bone Marrow

Ultrastructure of apoptotic T lymphocytes and thymicepithelial cells in early postnatal pig thymus

Physiologie de l’immunité colostrale chez les porcins et facteurs de variation du rendement et de la qualité immunitaire du colostrum de la truie

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