Early detection of tumour-associated antigens: Assessment of point-of-care electrochemical immunoassays

Block-Polymer-Restricted Sub-nanometer Pt Nanoclusters Nanozyme-Enhanced Immunoassay for Monitoring of Cardiac Troponin I

“…In the gradient concentration (0.02–20 ng mL –1 ) spiked recovery test, no outliers and false positive/negative results were found to occur, and the test results showed a high degree of consistency between the two methods, suggesting that the developed test protocol was able to accurately determine the concentration of cTnI in the actual samples from humans (Figure E). , In addition, clinical samples collected from potential patients were evaluated for accuracy according to the test protocol and the ELISA kit, and again no significant differences were found between the two test protocols, and the t exp were both less than 2.78, thus further defining the accuracy of the developed test protocol for evaluating cTnI targets (Table S4). In addition, a comparison of the test protocols that had reported for cTnI targets revealed that the game theory-based test protocol we developed could match or even outperform them in terms of dynamic response range and detection limit (Figure F). – …”

“…45,46 In addition, clinical samples collected from potential patients were evaluated for accuracy according to the test protocol and the ELISA kit, and again no significant differences were found between the two test protocols, and the t exp were both less than 2.78, thus further defining the accuracy of the developed test protocol for evaluating cTnI targets (Table S4). 47 In addition, a comparison of the test protocols that had reported for cTnI targets revealed that the game theory-based test protocol we developed could match or even outperform them in terms of dynamic response range and detection limit (Figure 4F). 48−57…”

RNA-cleaving DNAzymes for accurate biosensing and gene therapy

“…Accurate analysis of disease-related markers is critically essential for early diagnosis and making a treatment plan. 1,2 In recent years, the appearance of some new biological detection and therapeutic technologies has improved the quality of life of patients and provided a chance for survival. However, some actual obstacles still hinder the practical applications of these technologies.…”

Platinum nanozyme-mediated temperature sensor for sensitive photothermal immunoassay of YKL-40 under near-infrared light

“…11,12 Point-of-care testing (POCT) and medical testing at the site of patient care bring the test conveniently and immediately to the patient. 13 Yu et al prepared a paper electrode-based flexible pressure sensor for the point-of-care immunoassay using a digital multimeter. 14 Zeng et al constructed a smartphone-based electrochemical immunoassay for the point-of-care detection of SARS-CoV-2 nucleocapsid protein.…”