Early Detection of Tumor Response Using 4D DCE-CT and DCE-MRI in Patients Treated With Radiosurgery for Brain Metastases

Chung, Caroline; Driscoll, Brandon; Gorjizadeh, Alborz; Foltz, Warren D.; Lee, S.; Ménard, Cynthia; Coolens, Catherine

doi:10.1016/j.prro.2013.01.062

Cited by 1 publication

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“…Although the quantitative and semi-quantitative analyses are of great interest in scientific investigation, the additional benefit in clinical routine is still controversial. The reasons for this are varied but can likely be grouped into tumor heterogeneity and the need for voxel wise analysis on the one hand and the lack of validation and standardization in the analysis methods on the other hand [ 3 , 35 ]. The requirement for voxel wise analysis is clearly demonstrated in a study developing a parametric temporal approach to voxel-based tissue classification and analysis from 4D DCE CT of the brain [ 36 ].…”

Section: Biological Imagingmentioning

confidence: 99%

“…Utilizing the phantom-validated DCE CT parametric analysis as a gold standard in terms of contrast enhancement, a follow-up study then set out to compare the early detection of tumor response using DCE MRI against 4D DCE CT in the same patient cohort [ 35 , 36 ]. Perfusion images were acquired in the same patient on the same days with both modalities over the course of treatment.…”

Section: Biological Imagingmentioning

confidence: 99%

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Transformational Role of Medical Imaging in (Radiation) Oncology

Coolens

Gwilliam

Alcaide‐Leon

et al. 2021

Cancers

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Onboard, real-time, imaging techniques, from the original megavoltage planar imaging devices, to the emerging combined MRI-Linear Accelerators, have brought a huge transformation in the ability to deliver targeted radiation therapies. Each generation of these technologies enables lethal doses of radiation to be delivered to target volumes with progressively more accuracy and thus allows shrinking of necessary geometric margins, leading to reduced toxicities. Alongside these improvements in treatment delivery, advances in medical imaging, e.g., PET, and MRI, have also allowed target volumes themselves to be better defined. The development of functional and molecular imaging is now driving a conceptually larger step transformation to both better understand the cancer target and disease to be treated, as well as how tumors respond to treatment. A biological description of the tumor microenvironment is now accepted as an essential component of how to personalize and adapt treatment. This applies not only to radiation oncology but extends widely in cancer management from surgical oncology planning and interventional radiology, to evaluation of targeted drug delivery efficacy in medical oncology/immunotherapy. Here, we will discuss the role and requirements of functional and metabolic imaging techniques in the context of brain tumors and metastases to reliably provide multi-parametric imaging biomarkers of the tumor microenvironment.

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Section: Biological Imagingmentioning

confidence: 99%

Section: Biological Imagingmentioning

confidence: 99%