Early Detection of Steatohepatitis in Fatty Rat Liver by Using MR Elastography

Salameh, Najat; Larrat, Benoît; Abarca‐Quinones, Jorge; Pallu, Stéphane; Dorvillius, Mylène; Leclercq, Isabelle; Fink, Mathias; Sinkus, Ralph; Beers, Bernard E. Van

doi:10.1148/radiol.2523081817

Cited by 131 publications

(121 citation statements)

References 36 publications

(50 reference statements)

Supporting

Mentioning

117

Contrasting

Order By: Relevance

“…These include double contrast-enhanced MRI [20], MR elastography [8,21] and diffusion-weighted imaging [8,22]. These techniques' sensitivity for early liver fibrosis, reproducibility and intersite variability have not been well established [23].…”

Section: Discussionmentioning

confidence: 99%

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Deng

Zhao²,

Yuan³

et al. 2012

BJR

View full text Add to dashboard Cite

Objectives: The aim of this study was to explore the technical feasibility of T 1 r MRI for the liver, and to determine the normal range of liver T 1 r in healthy subjects at clinical 3 T. Methods: There were 15 healthy volunteers. Three representative axial slices were selected to cut through the upper, middle and lower liver. A rotary echo spin-lock pulse was implemented in a two-dimensional fast-field echo sequence. Spin-lock frequency was 500 Hz, and the spin-lock times of 1, 10, 20, 30, 40 and 50 ms were used for T 1 r mapping. The images were acquired slice by slice during breath-holding. Regions of interest (ROIs; n55) were manually placed on each slice of the liver parenchyma region, excluding artefacts and vessels. The mean value of these ROIs (n515) was regarded as the liver T 1 r value for the subject. Six subjects were scanned once at fasting status; six subjects were scanned once 2 h post meal; three subjects were scanned twice at fasting status; and seven subjects were scanned twice 2 h post meal. Results: When two readers measured the same 10 data sets, the interreader reproducibility (ICC: intraclass correlation coefficient) was 0.955. With the 10 subjects scanned twice, the ICC for scan-rescan reproducibility was 0.764. There was no significant difference for the liver T 1 r value at the fasting status (43.08¡1.41 ms) and post-meal status (42.97¡2.38 ms, p50.867). Pooling together all the 32 scans in this study, the normal liver T 1 r value ranged from 38.6 to 48.3 ms (mean 43.0 ms, median 42.6 ms). Conclusion: It is feasible to obtain consistent liver T 1 r measurement for human subjects at 3 T.

show abstract

Section: Discussionmentioning

confidence: 99%

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Deng

Zhao²,

Yuan³

et al. 2012

BJR

View full text Add to dashboard Cite

show abstract

“…For example, elastography is being explored as a modality for longitudinal monitoring of liver (73,74). Investigation is ongoing with regard to the use of elastography to distinguish an inflammationrelated increase in liver stiffness from that related to fibrosis (75). If successful, this distinction could help identify hepatic inflammation in the prefibrosis stage, resulting in earlier treatment.…”

Section: Liver Elastography: Future Directionsmentioning

confidence: 99%

Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions

Babu¹,

Wells²,

Teytelboym³

et al. 2016

RadioGraphics

161

101

View full text Add to dashboard Cite

“…The shear wave images were processed to produce images of hepatic stiffness (elastograms) by using a previously described direct inversion algorithm ( 38 ). The MR elastography sequence parameters were as follows: phase offsets, four; motion sensitivity, 10.2 m m/radian; axial imaging plane; superior-inferior motion-sensitizing direction; fi eld of view, 34-44 cm; acquisition matrix, 256 3 96; fractional phase fi eld of view, 0.75-1; fl ip angle, 30°; one signal acquired; bandwidth, 31.25 kHz; echo time msec/ repetition time msec, 24.5/50; section thickness, 10 mm; number of sections, two to four; imaging time, two to four However, a recent in vivo animal study reported that MR elastography-based liver stiffness measurements were able to discriminate the presence of steatohepatitis from simple steatosis prior to the onset of fi brosis in a rat model of fatty liver disease ( 37 ).…”

Section: Liver Stiffness Measurementmentioning

confidence: 99%

Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography

Chen¹,

Talwalkar²,

Yin³

et al. 2011

Radiology

389

299

View full text Add to dashboard Cite

Purpose:To investigate the diagnostic accuracy (area under the receiver operating characteristic curve [AUROC]) of magnetic resonance (MR) elastography for the early detection of nonalcoholic steatohepatitis (NASH) among patients with nonalcoholic fatty liver disease (NAFLD). Materials and Methods:An institutional review board-approved and HIPAAcompliant retrospective study was conducted in 58 NAFLD patients. Informed consent was waived by the review board. Hepatic stiffness, relative fat fraction, infl ammation grade, and fi brosis stage were assessed from MR elastography, in-phase and out-of-phase gradient-echo imaging, and liver biopsy histopathologic review, respectively. Pairwise t testing, receiver operating characteristic analysis, and partial correlation analysis were performed. Results:The mean hepatic stiffness for patients with simple steatosis (2.51 kPa) was less ( P = .028) than that for patients with infl ammation but no fi brosis (3.24 kPa). The mean hepatic stiffness for patients with infl ammation but no fibrosis was less ( P = .030) than that for patients with hepatic fi brosis (4.16 kPa). Liver stiffness had high accuracy (AUROC = 0.93) for discriminating patients with NASH from those with simple steatosis, with a sensitivity of 94% and a specifi city 73% by using a threshold of 2.74 kPa. Conclusion:In patients with NAFLD, hepatic stiffness measurements with MR elastography can help identify individuals with steatohepatitis, even before the onset of fi brosis; NAFLD patients with infl ammation but no fi brosis have greater liver stiffness than those with simple steatosis and lower mean stiffness than those with fi brosis.q RSNA, 2011 1

show abstract

Early Detection of Steatohepatitis in Fatty Rat Liver by Using MR Elastography

Abstract: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2523081817/-/DC1.

Cited by 131 publications

References 36 publications

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions

Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography

Contact Info

Product

Resources

About

Early Detection of Steatohepatitis in Fatty Rat Liver by Using MR Elastography

Abstract: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2523081817/-/DC1.

Cited by 131 publications

References 36 publications

LiverT1ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

LiverT1ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

Elastography in Chronic Liver Disease: Modalities, Techniques, Limitations, and Future Directions

Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography

Contact Info

Product

Resources

About

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence

LiverT₁ρMRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence