Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography

Chen, Jun; Talwalkar, Jayant A.; Yin, Min-Jean; Glaser, Kevin J.; Sanderson, Schuyler O.; Ehman, Richard L.

doi:10.1148/radiol.11101942

Cited by 389 publications

(310 citation statements)

References 60 publications

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“…Although steatosis itself might not aŠect the stiŠness measurement, fat deposition can cause in‰ammation, which, in turn, can increase liver stiŠness even in the absence of brosis. 32,33 The in‰uence of these factors should be further studied in larger series. However, a previous study suggested a signiˆcant correlation of liver stiŠness measured by transient ultrasound elastography withˆbrosis but not with in‰ammatory activity and steatosis.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C

et al. 2012

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Purpose: We evaluated the use of magnetic resonance (MR) elastography (MRE) for staging liverˆbrosis in patients with chronic hepatitis C and compared the ability of MRE and serumˆbrosis markers for discriminating each stage ofˆbrosis.Methods: We evaluated 114 patients with chronic hepatitis C in whom the pathological brosis stage was determined (ˆbrosis stage 0 [F0], 3; F1, 15; F2, 28; F3, 25; and F4, 43). All patients underwent MRE using a 1.5-tesla MR system and pneumatic driver system. We measured stiŠness values (kPa) of the liver in a circular region of interest placed on elastograms. We determined the optimal cutoŠ value and diagnostic ability for discriminating each stage ofˆbrosis using receiver operating characteristic (ROC) curve analysis and compared the discriminative ability of MRE with that of serumˆbrosis markers. Conclusion: MRE is a reliable technique for staging liverˆbrosis and discriminating liver brosis stages in patients with chronic hepatitis C.

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Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C

et al. 2012

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“…Chen et al demonstrated that using MR elastography, differentiating steatosis, steatohepatitis, and fi brosis is possible. Patients with infl ammation but without fi brosis have greater liver stiffness than those with simple steatosis but lower stiffness than those with fi brosis (Chen et al 2011 ).…”

Section: Hepatic Steatosis and Steatohepatitismentioning

confidence: 94%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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“…As MRE is proving to be an accurate and reliable test, many single etiology studies with MRE in diseases such as hepatitis B, hepatitis C, alcoholic liver disease and NASH have emerged [141,[146][147][148][149], and all show high performance (accuracy [ 0.90) of MRE in the detection of fibrosis. Large population studies are still lacking.…”

Section: Magnetic Resonance Elastography (Mre)mentioning

confidence: 99%

Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

et al. 2016

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Early Detection of Nonalcoholic Steatohepatitis in Patients with Nonalcoholic Fatty Liver Disease by Using MR Elastography

Cited by 389 publications

References 60 publications

Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C

Magnetic Resonance Elastography for Staging Liver Fibrosis in Chronic Hepatitis C

Female Pelvis: Genital Organs

Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

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