Early detection of sepsis in newborn clinic, is it possible?

Köroğlu, Mehmet; Terzi, Hüseyin Agah; Gürol, Gönül; Demiray, Tayfur; Özbek, Ahmet; Hafızoğlu, Taner

doi:10.1016/j.clinbiochem.2014.04.074

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“…It generates an economic impact, for example, the annual cost of deaths in newborns that are due to sepsis in the United States is 1.97 billion dollars [ 3 ]. EONS develops within the newborn’s first 72 h of life [ 4 ]. There is a certain degree of difficulty in its diagnosis due to the non-specific clinical manifestations in this type of patient.…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies

et al. 2022

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Introduction: Early onset neonatal sepsis (EONS), particularly in preterm sepsis, is a potentially fatal issue. Evaluation of mean platelet volume (MPV) as an EONS predictor was the goal. Methods: Four databases were used to conduct a systematic evaluation of cohort and case–control studies. Up till the end of October 2022, 137 articles were found utilizing the search method. Following the review, 12 studies were included. Leukocytes, MPV, platelets, gender, birth weight, gestational age, mortality, and C-reactive protein (CRP) were all taken into account while analyzing the prediction of EONS. Inverse-variance methodology and the random-effects model were used. Using GRADE, the evidence’s quality was evaluated. Results: Neonatal patients with sepsis had significantly higher MPV levels than do neonates without sepsis (MD 1.26; 95% CI 0.89–1.63; p < 0.001). An increased MPV during the first 24 h postpartum was associated with high CRP values and high risk of neonatal mortality. In the investigations, the MPV cutoff for sepsis patients was 9.95 (SD 0.843). Overall certainty of the evidence was very low. Conclusions: The increased MPV during the first 24 h postpartum may be predictive of EONS and mortality. Future studies are warranted.

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Section: Introductionmentioning

confidence: 99%