Mean Platelet Volume in Neonatal Sepsis: Meta-Analysis of Observational Studies

Abstract

Introduction: Early onset neonatal sepsis (EONS), particularly in preterm sepsis, is a potentially fatal issue. Evaluation of mean platelet volume (MPV) as an EONS predictor was the goal. Methods: Four databases were used to conduct a systematic evaluation of cohort and case–control studies. Up till the end of October 2022, 137 articles were found utilizing the search method. Following the review, 12 studies were included. Leukocytes, MPV, platelets, gender, birth weight, gestational age, mortality, and C-reactive protein (CRP) were all taken into account while analyzing the prediction of EONS. Inverse-variance methodology and the random-effects model were used. Using GRADE, the evidence’s quality was evaluated. Results: Neonatal patients with sepsis had significantly higher MPV levels than do neonates without sepsis (MD 1.26; 95% CI 0.89–1.63; p < 0.001). An increased MPV during the first 24 h postpartum was associated with high CRP values and high risk of neonatal mortality. In the investigations, the MPV cutoff for sepsis patients was 9.95 (SD 0.843). Overall certainty of the evidence was very low. Conclusions: The increased MPV during the first 24 h postpartum may be predictive of EONS and mortality. Future studies are warranted.

Clinical Value of Laboratory Biomarkers for the Diagnosis and Early Identification of Culture-Positive Sepsis in Neonates

“…Although the exact underlying mechanism remains unclear, it is speculated that MPV alterations may reflect the severity and progression of sepsis in neonates. 15,29 Our study highlights the significance of gestational age, CRP, and MPV as predictors for the diagnosis interval of neonatal sepsis. Understanding the relationship between these factors and ADI can facilitate early identification and prompt intervention, ultimately leading to improved patient outcomes.…”

“…14 In contrast, MPV was a diagnostic rather than a prognostic marker in neonatal sepsis. 15 Therefore, the hematology profiles still have a non-negligible role in the diagnosis of neonatal sepsis. Combinations of biomarkers are more valuable than used alone despite their limitations.…”

The Impact of Blood Morphological Parameters on Treatment Outcomes in Tennis Elbow Patients Receiving Platelet-Rich Plasma (PRP) Therapy: A Prospective Study

“…Studies conducted in patients with ulcerative colitis, appendicitis, and newborns with acute respiratory disorders have revealed a relationship between MPV and the severity of the clinical condition. However, there is no conclusion as to whether the variability in the indicator is only a useful additional diagnostic marker or just one of the parameters affected by the developing inflammatory state [ 44 , 45 , 46 , 47 ]. It is worth emphasizing that a higher MPV is associated with greater platelet activity [ 48 , 49 , 50 ].…”

Profile of Immature to Total Neutrophil (IT) Ratio and Platelet to Lymphocyte Ratio as Initial Predictive Value of Early Onset Neonatal Sepsis at Sanjiwani Hospital, Gianyar, Bali

“…Platelets also have a toll-like receptor (TLR), a receptor that may recognize different pathogen-associated molecular patterns (PAMP). Interaction between TLR and its ligand may directly cause platelet activation [19], [20].…”