Early Detection of Coagulation Abnormalities in Patients at Nutritional Risk: The Novel Role of Thromboelastography

Xu, Zhiwu; Li, Yousheng; Yang, Xiu-Fang; Wang, Jian; Li, Jieshou

doi:10.1177/000313481408000129

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…For example, four linkages (A/G-MCH, A/G-MCHC, Alb-uSG, TP-uSG) were changed from none to positive correlations (r = 0.339–0.834) in the BD patients regardless of treatment (Fig. 5 a-c), indicating the role of nutrition in BD pathogeneses [ 28 – 30 ]. As important inflammatory and thrombosis markers in BD, WBC (r = 0.532, P = 0.04) and NEUT (r = 0.593, P = 0.02) showed a significantly positively correlation with PLT in BD patients without immunomodulatory treatment (Fig.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive analysis of immunoglobulin and clinical variables identifies functional linkages and diagnostic indicators associated with Behcet’s disease patients receiving immunomodulatory treatment

Cheng

Yang

et al. 2021

BMC Immunol

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Background Behcet’s disease (BD) is a relapsing systemic vascular autoimmune/inflammatory disease. Despite much effort to investigate BD, there are virtually no unique laboratory markers identified to help in the diagnosis of BD, and the pathogenesis is largely unknown. The aim of this work is to explore interactions between different clinical variables by correlation analysis to determine associations between the functional linkages of different paired variables and potential diagnostic biomarkers of BD. Methods We measured the immunoglobulin proteome (IgG, IgG1–4, IgA, IgA1–2) and 29 clinical variables in 66 healthy controls and 63 patients with BD. We performed a comprehensive clinical variable linkage analysis and defined the physiological, pathological and pharmacological linkages based on the correlations of all variables in healthy controls and BD patients without and with immunomodulatory therapy. We further calculated relative changes between variables derived from comprehensive linkage analysis for better indications in the clinic. The potential indicators were validated in a validation set with 76 patients with BD, 30 healthy controls, 18 patients with Takayasu arteritis and 18 patients with ANCA-associated vasculitis. Results In this study, the variables identified were found to act in synergy rather than alone in BD patients under physiological, pathological and pharmacological conditions. Immunity and inflammation can be suppressed by corticosteroids and immunosuppressants, and integrative analysis of granulocytes, platelets and related variables is likely to provide a more comprehensive understanding of disease activity, thrombotic potential and ultimately potential tissue damage. We determined that total protein/mean corpuscular hemoglobin and total protein/mean corpuscular hemoglobin levels, total protein/mean corpuscular volume, and plateletcrit/monocyte counts were significantly increased in BD compared with controls (P < 0.05, in both the discovery and validation sets), which helped in distinguishing BD patients from healthy and vasculitis controls. Chronic anemia in BD combined with increased total protein contributed to higher levels of these biomarkers, and the interactions between platelets and monocytes may be linked to vascular involvement. Conclusions All these results demonstrate the utility of our approach in elucidating the pathogenesis and in identifying novel biomarkers for autoimmune diseases in the future.

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Section: Resultsmentioning

confidence: 99%