Early Clinical Recognition of Disseminated Candidiasis by Muscle and Skin Biopsy

Kressel, Bruce

doi:10.1001/archinte.1978.03630270061021

Cited by 59 publications

(10 citation statements)

References 24 publications

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“…Several authors have stressed the great difficulty of diagnosing invasive candidiasis in immunocompromised patients (9,11,14,18,19,24,25). In our patient, the diagnosis of systemic infection with a Candida species was first indicated by blood culture.…”

Section: Discussionmentioning

confidence: 89%

Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis

Ahearn¹,

Lawrence²

1984

J Clin Microbiol

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A patient suffering from leukemic transformation of a non-Hodgkin's lymphoma developed fatal disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis. The results of histopathological tests showed massive tissue invasion in many organs. The course of infection and the tissue morphology of the etiological agent were indistinguishable from those of C. albicans and typical C. tropicalis strains.

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Section: Discussionmentioning

confidence: 89%

Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis

Ahearn¹,

Lawrence²

1984

J Clin Microbiol

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“…ADC has a more rapidly progressive clinical picture and usually refers to the presence of infection with Candida species at two or more noncontiguous sites. In the proper clinical setting, the presence of multiple deep-seated cutaneous lesions due to Candida species is also indicative of disseminated infection [54][55][56][57][58] Probably the most important factor predicting the outcome of infection due to Fusarium is the immune status of the host. All patients with an underlying malignancy and disseminated fusarial infection had severe neutropenia at the onset of their infection [7].…”

Section: The Spectrum Of Disseminated Candidiasis In the Neutropenic mentioning

confidence: 99%

Opportunistic Mycoses in the Immunocompromised Host: Experience at a Cancer Center and Review

Anaissie

1992

Clinical Infectious Diseases

341

172

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The field of opportunistic mycoses in the patient with cancer is rapidly changing. Not only are fungal infections increasing in frequency in this patient population, but these infections are occurring earlier during the course of cytotoxic chemotherapy, and newer fungi are increasingly recognized as potentially lethal pathogens. Candidiasis remains the most commonly encountered infection. The spectrum of disease includes candidemia and acute and chronic disseminated candidiasis. Pulmonary aspergillosis and disseminated aspergillosis are common and remain relatively resistant to therapy. Disseminated fusariosis and trichosporosis are almost always fatal in the setting of persistent profound neutropenia. Therapy for these mycoses relies on the use of amphotericin B and 5-fluorocytosine. Newer antifungal agents, such as fluconazole and itraconazole, appear to exhibit good activity against a variety of fungi. Newer approaches need to be tested for the treatment of the more-resistant mycoses and may include the use of maximally tolerated doses of antifungal agents, colony-stimulating factors, and combination therapy.

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“…Although muscle biopsy was not found to be a useful diagnostic tool in the rabbit model of disseminated candidiasis, recent clinical reports have suggested that in patients with disseminated candidiasis, this procedure may be ofvalue (12). Interestingly, both patients reported in the latter study, as well as one of the previously reported patients (6), were neutropenic patients with leukemia.…”

Section: Discussionmentioning

confidence: 68%

“…Additionally, isolated case reports of skeletal muscle involvement in cases of disseminated candidiasis (6,12,16) led to our evaluation of muscle biopsy as a diagnostic tool in the rabbit model of disseminated Candida infection.…”

mentioning

confidence: 99%

Experimental hematogenous Candida endophthalmitis: diagnostic approaches

Henderson¹,

Edwards²,

Ishida³

et al. 1979

Infect Immun

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Anterior chamber aspiration and vitreous aspiration were evaluated as diagnostic procedures for establishing a specific microbiological diagnosis in the rabbit model of hematogenous Candida endophthalmitis. Vitreous aspiration was the most successful procedure, confirming the diagnosis of hematogenous Candida endophthalmitis in 62% of eyes with documented intraocular infection. When animals with only the most severe clinical endophthalmitis were considered, vitreous aspiration confirmed the diagnosis in 89% of eyes evaluated. Vitreous aspiration correlated well with the extent of clinical endophthalmitis, as well as with postmortem, whole-vitreous cultures. Gram staining of the aspirate was additive to culture results in confirming the diagnosis. Anterior chamber aspiration was positive in only 1 of 58 eyes evaluated (1.7%). Additionally, muscle biospy was evaluated in this study as a tool for establishing a microbiological diagnosis in the rabbit model of disseminated candidiasis. Only 2 of 131 biospy specimens contained detectable Candida. Although vitreous aspiration may be associated with ocular complications, in certain clinical settings this procedure may be valuable in establishing the definitive microbiological diagnosis of hematogenous Candida endophthalmitis.

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Early Clinical Recognition of Disseminated Candidiasis by Muscle and Skin Biopsy

Cited by 59 publications

References 24 publications

Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis

Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis

Opportunistic Mycoses in the Immunocompromised Host: Experience at a Cancer Center and Review

Experimental hematogenous Candida endophthalmitis: diagnostic approaches

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