Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis

Ahearn, Donald G.; Lawrence, James

doi:10.1128/jcm.20.2.187-190.1984

Cited by 18 publications

(13 citation statements)

References 21 publications

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“…All isolates reduced TTC to a dark red formazan within 24 h. This type of reaction is also observedfor typical isolates of C. tropicalis (8,9). The isolates included three strains (GSU 59, GSU 372, GSU 446) initially reported as sucrose-negative variants of C. tropicalis (2). Previously these strains were reported to assimilate inulin; however, by our procedures and criteria, only one isolate (GSU 372) gave weak growth which approached our minimal criterion for a positive reaction.…”

Section: Resultssupporting

confidence: 64%

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Characterization of atypical Candida tropicalis and other uncommon clinical yeast isolates

Schlitzer¹,

Ahearn²

1982

J Clin Microbiol

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Clinical yeast isolates representing ot-glucoside-deficient variants of Candida tropicalis, C. lusitaniae, atypical C. albicans, and Saccharomyces cerevisiae were characterized. Additional physiological tests, including cellobiose fermentation, rhamnose assimilation, and triphenyl tetrazolium chloride reduction, are recommended for the detection and presumptive identification of uncommon Candida spp. in the clinical laboratory. Certain disease syndromes and associated

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Section: Resultssupporting

confidence: 64%

“…Advances in therapy and surgical procedures that have sustained life in situations where previously it would have been improbable have been accompanied by the increased threat of secondary infection by yeasts. Moreover, the spectrum of yeasts involved in infections of debiliated patients has increased (1,2,21).…”

mentioning

confidence: 99%

Characterization of atypical Candida tropicalis and other uncommon clinical yeast isolates

Schlitzer¹,

Ahearn²

1982

J Clin Microbiol

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“…The most frequently reported agents of secondary mycotic diseases are the yeast Candida a/bicans and the filamentous fungus Aspergillus fumigatus. The spectrum of the fungus species playing a role in the aetiology of mycoses has been constantly increasing and infections with earlier less known agents, e. g. Candida tropicalis [8], Torulopsis glabrata [9] and Trichosporon beigelii [10], begin to appear. In recent years the pathogenic importance of the yeast Trichosporon capitatum has been on the increase as well.…”

Section: Introductionmentioning

confidence: 99%

Pathogenicity of Trichosporon capitatum for normal and irradiated mice and the efficacy of miconazole on experimental systemic trichosporosis in mice

Pospíšil¹,

Postupa²,

Otčenášek³

et al. 1990

Mycoses

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The authors describe the course of experimental trichosporosis in normal and X-irradiated ICR mice after i.v. inoculation with Trichosporon capitatum. The irradiated animals were considerably more sensitive to infection than normal animals. The LD50 challenge dose used was by approximately two orders lower (1 X 10(3) c.f.u. ml-1) in irradiated mice than in control animals. The histopathological examination of the internal organs of the infected mice demonstrated that the greatest tissue damage was associated with the kidneys, liver and spleen. However, the infectious agent was also found in heart, lungs and brain. The degree of impairment of the tissues was dependent on the inoculation dose and on the irradiation status. Miconazole (50 mg kg-1) was administered i.p. immediately after inoculation with Ts. capitatum and resulted in an alteration of infection and prolonged survival time. Miconazole was ineffective when challenge dose were used which produced 100% mortality (1 X 10(6) and 1 X 10(4) c.f.u. ml-1 for normal and irradiated mice, respectively). With the use of these doses also the course of infection was nearly identical both in the miconazole-treated and untreated animals.

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“…Candidemia has been responsible for significant morbidity and mortality rates among immunocompromised patients (Molero et al, 1998;Pasqualotto et al, 2007;Karkowska-Kuleta et al, 2009). Recently, the frequency of candidemia's occurrence caused by non-albicans species, such as Candida glabrata (C. glabrata), Candida tropicalis (C. tropicalis), and Candida parapsilosis (C. parapsilosis), have been increasing (Ahearn and Lawrence, 1984;Fromtling et al, 1987;Fidel et al, 1999;Nosek et al, 2009). Furthermore, various fungal infections caused by Trichosporon, Cryptococcus neoformans, Saccharomyces species, and other uncommon yeasts have been widely reported (Denning et al, 1990;McCusker et al, 1994;Wolf et al, 2001;O'Gorman et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Isolation frequency and epidemiological characterization of yeast-like fungi and co-infected bacteria isolated from clinical patient

Park¹,

Kim²,

Kang³

et al. 2016

J. Yeast Fungal Res.

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Pathogenic yeast-like fungi and bacteria are found all over the world, and are a frequent cause of invasive disease in immunocompromised hosts. However, there is a paucity of data on pathogenic yeast-like fungi in Korea. In this study, the characterization of pathogenic yeast-like fungi and coinfected bacteria isolated from 715 patients (ranging in age from 29 days to 99 years, with a mean age of 49 years) that were collected from general hospitals (from April 2011 to March 2013) in Busan were investigated. A total of 744 pathogenic yeast-like fungi and 170 six bacterial strains were isolated from clinical samples. The majority of isolates from sputum and urine samples were obtained from patients. The isolation frequency by sex was similar in females (48.6%) and males (51.4%). It was higher in individuals over 60 years of age (67.5%) than in younger individuals. The Candida species most frequently isolated from clinical samples was Candida albicans (64.0%), followed by Candida tropicalis (18.1%), Candida glabrata (8.6%), Candida parapsilosis (5.0%), Candida krusei (0.7%), and other Candida species (1.9%). The non-Candida species isolated most frequently from clinical samples was the Trichosporon species (1.2%). Although C. albicans was the most common species in almost clinical samples, C. tropicalis (47.6%) was most common species in urine samples. Staphylococcus aureus (15.3%) and Klebsiella pneumoniae (10.2%) were commonly isolated from patients infected with C. albicans. Although the epidemiology of pathogenic yeast-like fungal infection has been reported, these results are the first on the distribution of yeast-like fungi and co-infected bacteria from patients in Korea.

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Disseminated candidiasis caused by a sucrose-negative variant of Candida tropicalis

Cited by 18 publications

References 21 publications

Characterization of atypical Candida tropicalis and other uncommon clinical yeast isolates

Characterization of atypical Candida tropicalis and other uncommon clinical yeast isolates

Pathogenicity of Trichosporon capitatum for normal and irradiated mice and the efficacy of miconazole on experimental systemic trichosporosis in mice

Isolation frequency and epidemiological characterization of yeast-like fungi and co-infected bacteria isolated from clinical patient

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