Early Childhood Wheezing Is Associated With Lower Lung Function In Cystic Fibrosis

Ren, Clement L.; Rosenfeld, Margaret; Konstan, Michael W.; Millar, Stefanie J.; Pasta, David J.; Morgan, Wayne J.

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5361

Cited by 9 publications

(14 citation statements)

References 3 publications

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“…Finally, when considering a 10% ΔFEV 1 improvement (the amount of FEV 1 decrease usually used to define pulmonary exacerbation and 20% for ΔX5 (as demonstrated in the study reported by Ren et al) to be clinically meaningful, we found that 27 out of 34 (79%) measurements were above this cut‐off value for ΔFEV 1 , while only 15 out of 34 (44%) were above this cut‐off for ΔX5 (Fig. ).…”

Section: Resultssupporting

confidence: 59%

An impulse oscillometry system is less efficient than spirometry in tracking lung function improvements after intravenous antibiotic therapy in pediatric patients with cystic fibrosis

Buchs¹,

Coutier

Vrielynck³

et al. 2015

Pediatric Pulmonology

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A literature search identified one retrospective study on the responsiveness of impulse oscillometry (IOS) in pediatric patients with cystic fibrosis. The aim of this prospective observational study was to assess this property in an adequately powered study after intravenous antibiotic therapy (IVAT) administered for an acute episode of pulmonary exacerbation. Spirometry and IOS were done on the same day as the start and the end of IVAT. Data from 34 patients' of mean age 11.9 years (range, 5-17 years) were studied. The mean FEV1 at the start and at the end of the IVAT was 73.1 ± 23.8% (range, 23.4-122%) and 88.3 ± 21.3% (range, 29.4-131%), respectively. The mean relative change (mean ± SD) was 20.2 ± 14.2% for FEV1 (ΔFEV1 ), -21.9 ± 23.8% for reactance at 5 Hz (ΔX5) and -13.4 ± 18.9% for resistance at 5 Hz (Δ R5) (all P-values <0.05). There was a weak but significant correlation between ΔFEV1 and ΔX5 (r =-0.473; p = 0.01). The magnitude of improvement of ΔX5 was not statistically different between patients with normal versus abnormal lung function at the start of IVAT. Furthermore, using ΔX5 alone as an outcome measure of IVAT efficiency resulted in a significant improvement in 44% of the patients, while it was 79% with ΔFEV1 . These results indicate that IOS may track changes after IVAT, but that this improvement may be insufficiently evaluated using IOS alone.

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Section: Resultssupporting

confidence: 59%

An impulse oscillometry system is less efficient than spirometry in tracking lung function improvements after intravenous antibiotic therapy in pediatric patients with cystic fibrosis

Buchs¹,

Coutier

Vrielynck³

et al. 2015

Pediatric Pulmonology

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“…Since young females have larger airways and decreased airway reactivity than young males, one can postulate that, young females with CF have to develop more airway disease before they reach the threshold for symptoms (and possibly decreases in lung function) as compared to males. A recent study supports this hypothesis: Ren et al reported that males with CF had more wheezing (65.7%) than females (55.7%) in the first 6 years of life . The FEV1 values at ages 6–7 and 8–9 years were similar between the sexes.…”

Section: Cystic Fibrosismentioning

confidence: 75%

Sex and the lung: Observations, hypotheses, and future directions

2015

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Sex-related differences in a variety of lung diseases in infants and young children are reviewed, including respiratory distress syndrome, and chronic lung disease of prematurity, lower respiratory tract illnesses and wheezing, asthma, diffuse, and interstitial lung diseases, and cystic fibrosis. Differences in anatomy and physiology, such as airway size, airway muscle bulk, airway reactivity, airway tone, and cough reflexes may explain much of these sex differences. Better understanding of sex-related lung differences could help personalize respiratory treatment.

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“…(25) Although we did not observe a reduced lung function in cat or dog owners, we only assessed cross-sectional lung function and not longitudinal. Exposure to cats in early life has been reported to be associated with wheezing in the general population with postulated mechanisms to include allergen exposure, immune-modulation via bacterial endotoxins, and/or transmission of infectious organisms.…”

Section: Discussionmentioning

confidence: 88%

Cat and Dog Exposure and Respiratory Morbidities in Cystic Fibrosis

Morrow¹,

Raraigh²,

Green³

et al. 2014

The Journal of Pediatrics

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Objective To understand the triggers that may impact respiratory health in cystic fibrosis (CF), including the effects of pets, because environmental factors contribute to one-half of the variation in lung function in patients with CF. Study design A total of 703 subjects with CF were recruited through the U.S. CF Twin-Sibling Study. Questionnaires were used to determine the presence/absence of cats and dogs in households with a child with CF. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track respiratory and infection outcomes. Results Within the sample 47% of subjects reported owning a dog, and 28% reported owning a cat. After adjustment for demographic factors, dog ownership was not associated with any adverse clinical outcomes, and cat ownership was associated an increased risk in developing nasal polyps (adjusted OR 1.66; p=0.024) compared with non-cat owners. Subjects who owned both cats and dogs were twice as likely to report wheezing compared with other subjects (adjusted OR: 2.01; p=0.009). There were no differences in prevalence and age of acquisition for the common CF respiratory pathogens Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus between cat/dog owners and non-cat/dog owners. Conclusions Cat ownership was associated with a higher frequency of developing nasal polyps and combined cat-dog ownership was associated with a higher rate of wheezing. Prospective studies are needed to confirm these associations and the potential psychosocial benefits of cat and/or dog ownership.

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Early Childhood Wheezing Is Associated With Lower Lung Function In Cystic Fibrosis

Cited by 9 publications

References 3 publications

An impulse oscillometry system is less efficient than spirometry in tracking lung function improvements after intravenous antibiotic therapy in pediatric patients with cystic fibrosis

An impulse oscillometry system is less efficient than spirometry in tracking lung function improvements after intravenous antibiotic therapy in pediatric patients with cystic fibrosis

Sex and the lung: Observations, hypotheses, and future directions

Cat and Dog Exposure and Respiratory Morbidities in Cystic Fibrosis

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