Early Childhood Socioeconomic Status and Cognitive and Adaptive Outcomes at the Transition to Adulthood: The Mediating Role of Gray Matter Development Across Five Scan Waves

Deanna, M; Donohue, Meghan Rose; Elsayed, Nourhan M.; Gilbert, Kirsten; Hennefield, Laura; Herzberg, Max P.; Kandala, Sridhar; Karcher, Nicole R.; Jackson, Joshua J.; Luking, Katherine R.; Rappaport, Brent I.; Sanders, Ashley; Taylor, Rita L.; Tillman, Rebecca; Vogel, Alecia C.; Whalen, Diana J.; Luby, Joan L.

doi:10.1016/j.bpsc.2021.07.002

Cited by 20 publications

(24 citation statements)

References 75 publications

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“…In this meta-analysis, socioeconomic disadvantage encompassed poverty and ecological concomitants (e.g., neighborhood deprivation and crime). These results are consistent with longitudinal work showing attenuated temporal-limbic growth throughout childhood (Barch et al, 2021;Whittle et al, 2017) and faster cortical thinning (Piccolo et al, 2016) in relation to socioeconomic disadvantage. Similar to prior work on cortical surface area (Noble et al, 2015), socioeconomic disadvantage (vs. no exposure) was also associated with smaller prefrontal and parietal structures in this meta-analysis despite no age-related differences.…”

Section: Discussionsupporting

confidence: 90%

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis

Vannucci

Fields

Hansen

et al. 2023

Preprint

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It has been established that early-life adversity impacts brain development, but the role of development itself has largely been ignored. We take a developmentally-sensitive approach to examine the neurodevelopmental sequelae of early adversity in a preregistered meta-analysis of 27,234 youth (birth to 18-years-old), providing the largest group of adversity-exposed youth to date. Findings demonstrate that early-life adversity does not have an ontogenetically uniform impact on brain volumes, but instead exhibits age-, experience-, and region-specific associations. Relative to non-exposed comparisons, interpersonal early adversity (e.g., family-based maltreatment) was associated with initially larger volumes in frontolimbic regions until ~10-years-old, after which these exposures were linked to increasingly smaller volumes. By contrast, socioeconomic disadvantage (e.g., poverty) was associated with smaller volumes in temporal-limbic regions in childhood, which were attenuated at older ages. These findings advance ongoing debates regarding why, when, and how early-life adversity shapes later neural outcomes.

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Section: Discussionsupporting

confidence: 90%

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis

Vannucci

Fields

Hansen

et al. 2023

Preprint

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“…The structural data (T1w, T2w scans) were processed using HCP pipelines and FreeSurfer as described previously (Barch et al, 2022) to create the prerequisite anatomical information expected by FreeSurfer's TRACULA tool (Yendiki et al, 2011; Yendiki, Koldewyn, et al, 2014; Yendiki, Reuber, et al, 2014) for automatic construction of white‐matter pathways from dMRI data. The diffusion data were preprocessed using the “DiffusionPreprocessing” stream of HCP Pipelines (v4.0.1) (Glasser et al, 2013, 2016) followed by processing using TRACULA (from FreeSurfer v6.0) which included application of FSL's “bedpostx” (Behrens et al, 2007; Hernandez‐Fernandez et al, 2019) to estimate the diffusion distribution at each voxel.…”

Section: Methodsmentioning

confidence: 99%

White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions

Barch

Hua²,

Kandala

et al. 2022

Depression and Anxiety

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Introduction: Compared to research on adults with depression, relatively little work has examined white matter microstructure differences in depression arising earlier in life. Here we tested hypotheses about disruptions to white matter structure in adolescents with current and past depression, with an a priori focus on the cingulum bundles, uncinate fasciculi, corpus collosum, and superior longitudinal fasciculus.Methods: One hundred thirty‐one children from the Preschool Depression Study were assessed using a Human Connectome Project style diffusion imaging sequence which was processed with HCP pipelines and TRACULA to generate estimates of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD).Results: We found that reduced FA, reduced AD, and increased RD in the dorsal cingulum bundle were associated with a lifetime diagnosis of major depression and greater cumulative and current depression severity. Reduced FA, reduced AD, and increased RD in the ventral cingulum were associated with greater cumulative depression severity.Conclusion: These findings support the emergence of white matter differences detected in adolescence associated with earlier life and concurrent depression. They also highlight the importance of connections of the cingulate to other brain regions in association with depression, potentially relevant to understanding emotion dysregulation and functional connectivity differences in depression.

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“…income level, access to resources, parental stress, parental education) may directly or indirectly impact the developing brain, especially during the first year of life (Farah, 2018;Noble et al, 2015). For example, in structural brain imaging studies, lower levels of family income are associated with reduced volume in multiple areas of the brain that mediate language, memory, and executive functioning (reviewed in Barch et al, 2022;Farah, 2018;Noble et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Associations between Eeg Trajectories, Family Income, And Cognitive Abilities Over the First Two Years of Life

Wilkinson

Pierce

Wade

et al. 2023

Preprint

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Early Childhood Socioeconomic Status and Cognitive and Adaptive Outcomes at the Transition to Adulthood: The Mediating Role of Gray Matter Development Across Five Scan Waves

Cited by 20 publications

References 75 publications

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis

White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions

Associations between Eeg Trajectories, Family Income, And Cognitive Abilities Over the First Two Years of Life

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