Early chest radiography and CT in the diagnosis, management and outcome of invasive pulmonary aspergillosis

Hauggaard, Anders; Ellis, Michael; Ekelund, Leif

doi:10.1034/j.1600-0455.2002.430310.x

Cited by 58 publications

(38 citation statements)

References 21 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-resolution computed tomography (HR-CT), however, displays a significantly higher sensitivity and specificity in depicting pulmonary infiltrates than conventional X-ray; therefore, recommendations tend towards performing HR-CT early in the diagnostic management in immunocompromised patients [12,16].…”

Section: Introductionmentioning

confidence: 98%

Pulmonary MRI—a new approach for the evaluation of febrile neutropenic patients with malignancies

Rieger

Herzog

Eibel

et al. 2007

Support Care Cancer

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 98%

Pulmonary MRI—a new approach for the evaluation of febrile neutropenic patients with malignancies

Rieger

Herzog

Eibel

et al. 2007

Support Care Cancer

View full text Add to dashboard Cite

show abstract

“…In 4 of 5 cases, CT demonstrated a higher number of nodules than observed on the corresponding chest radiograph. A CT halo sign (figure 2) [17] was identified in 1 patient; cavitation was present on the initial ( ) or follow-up ( ) studies for 4 patients n p 1 n p 3 ( figure 3). Associated pleural effusions were present in 4 of 8 patients.…”

Section: Resultsmentioning

confidence: 96%

Invasive Aspergillosis in the Setting of Cardiac Transplantation

Montoya

Chaparro²,

Celis

et al. 2003

CLIN INFECT DIS

View full text Add to dashboard Cite

Among patients undergoing heart transplantation, Aspergillus is the opportunistic pathogen with the highest attributable mortality. The median time of onset from transplantation for invasive pulmonary aspergillosis (IPA) was 46 days, but the median time to first positive culture result was 104 days among patients with Aspergillus colonization but no invasive disease. Most patients with IPA presented with fever and cough within the first 90 days of transplantation and with single or multiple pulmonary nodules. None of the heart transplant recipients with either IPA or invasive extrapulmonary aspergillosis (IEPA) had associated neutropenia. Human leukocyte antigen A1 locus was found significantly more frequently among patients colonized with Aspergillus than among patients with IPA (P<.006) or IEPA (P<.001). Even in the absence of neutropenia, IPA should be suspected for heart transplant recipients who have fever and respiratory symptoms within the first 3 months of transplantation, have a positive result of culture of respiratory secretions, and have abnormal radiological findings (particularly nodules).

show abstract

“…5 The prevalence of IPA is increasing in patients with hematologic malignancy, especially in those who are receiving aggressive regimens of cytotoxic chemotherapy. 1 Recent reports have shown improved survival rates in patients with IPA whose disease is diagnosed and treated earlier, 3,4,6 particularly in patients who recover from granulocytopenia that follows induction chemotherapy; therefore, making the diagnosis of this life-threatening infection plays a major role in the final outcome of the patient. However, the diagnosis of IPA remains a major challenge in patients with hematologic malignancies.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiologic predictors of invasive pulmonary aspergillosis in cancer patients

Hachem

Sumoza

Hanna

et al. 2006

Cancer

View full text Add to dashboard Cite

BACKGROUNDInvasive pulmonary aspergillosis (IPA) is a life‐threatening infection in immunocompromised patients. The outcome of such infections depends on early diagnosis and prompt initiation of therapy. The objective of the current study was to determine the significant predictive factors that characterize IPA in patients with cancer.METHODSThe clinical characteristics and computed tomography (CT) findings for 47 cases with IPA were retrospectively reviewed and compared with 49 controls (patients diagnosed on autopsy with nonfungal pneumonias). Data from all 96 patients were modeled using multivariate logistic regression. Subgroups of patients with common characteristics and outcomes were identified.RESULTSLeukemia, neutropenia, cavitation, and nodular lesions occurred significantly more often among cases than controls (P = 0.04, 0.004, 0.04, and 0.02, respectively). A quantitative scoring system was developed that could be used to identify patients as being at low, medium, and high risk for IPA.CONCLUSIONSIPA should be highly suspected in leukemia patients with profound neutropenia, pleuritic chest pain, and cavitary or nodular lesions detected on CT scan. These predictive factors can be used to indicate when early prophylactic and therapeutic antifungal interventions should be initiated. Cancer 2006. © 2006 American Cancer Society.

show abstract

Early chest radiography and CT in the diagnosis, management and outcome of invasive pulmonary aspergillosis

Abstract: Early chest CT in neutropenic patients at risk for IPA is an important diagnostic and management tool and should be included in the investigative protocol even when chest radiographs are normal or non-specific.

Cited by 58 publications

References 21 publications

Pulmonary MRI—a new approach for the evaluation of febrile neutropenic patients with malignancies

Pulmonary MRI—a new approach for the evaluation of febrile neutropenic patients with malignancies

Invasive Aspergillosis in the Setting of Cardiac Transplantation

Clinical and radiologic predictors of invasive pulmonary aspergillosis in cancer patients

Contact Info

Product

Resources

About