Pulmonary MRI—a new approach for the evaluation of febrile neutropenic patients with malignancies

Rieger, Christina; Herzog, Peter; Eibel, R.; Fiegl, Michael; Ostermann, Helmut

doi:10.1007/s00520-007-0346-4

Cited by 44 publications

(32 citation statements)

References 22 publications

(30 reference statements)

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“…In many studies of pulmonary infections in immunocompromised patients performed with various MRI sequences, the findings on CT and MRI have been compared. The most frequently used sequences are T2-weighted half Fourier single-shot turbo spin-echo (HASTE) (12)(13)(14), the T2-weighted ultrashort spin-echo (SE) sequence (15), and the T2-and T1-weighted turbo spinecho (TSE) sequences (16). However, few studies have compared different MRI sequences (16).…”

Section: Discussionmentioning

confidence: 99%

MRI of pneumonia in immunocompromised patients: comparison with CT

Ekinci

Uçarkuş²,

Okur³

et al. 2017

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 99%

MRI of pneumonia in immunocompromised patients: comparison with CT

Ekinci

Uçarkuş²,

Okur³

et al. 2017

Diagn Interv Radiol

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“…Chest radiographs are often normal or show few nonspecific abnormalities, which can delay diagnosis and treatment [3].Owing to its greater sensitivity and specificity in depicting pulmonary infiltrates, high resolution computed tomography [HRCT] scans are often performed early in the diagnostic management of immunosuppressed children [7].…”

Section: Introductionmentioning

confidence: 99%

“…The current accepted gold standard for the assessment of lung parenchymal changes in febrile neutropenia is the HRCT scan [7].…”

Section: Introductionmentioning

confidence: 99%

“…Brenner et al [13] stated that up to 1.5-2% of cancers diagnosed in the United States may be directly attributable to radiation exposure from CT scans. Many steps have been advocated to minimize radiation risks, including the ALARA principle (as low as reasonably achievable), low-dose CT protocols and proper implementation of justification principle [7][8]. However, these actions alone cannot completely eliminate the risks associated with radiation exposure from CT scans, as even low-dose radiation poses a definite risk [13][14].…”

mentioning

confidence: 99%

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Rapid lung MRI - paradigm shift in evaluation of febrile neutropenia in children with leukemia: a pilot study

Sodhi

Khandelwal

Saxena

et al. 2016

Leukemia & Lymphoma

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Immunocompromised children with hematological malignancies are at increased risk of developing potentially fatal pulmonary infections. Early detection and prompt treatment is critical to combat morbidity and mortality in these children. Twenty-six children with leukemia (age range: 5-13years) presenting with fever and neutropenia were included in this prospective study, which was approved by the institutional ethics committee. All patients underwent HRCT and MRI of the chest on the same day. The findings of HRCT and MRI were compared, with HRCT as the standard of reference. There was perfect agreement between MRI and CT examinations findings by kappa test (κ = 1). No significant difference was observed between the two modalities by the McNemar test (p > 0.05). Rapid lung MRI is technically feasible; has a high correlation, sensitivity and specificity to CT scan; and can emerge as the first line modality for the detection of pulmonary nodules in children with leukemia and persistent febrile neutropenia.

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“…In another study MRI showed a high correlation (91 %) with the findings in HR-CT in neutropenic patients with suspected pulmonary infection. The authors conclude that MRI makes it possible to perform follow-up examinations without repeated patient X-ray exposure [15]. This is an important argument for application especially in the pediatric population.…”

Section: Infectious Diseases Pneumoniamentioning

confidence: 97%

Clinical Application of MRI in Children for the Assessment of Pulmonary Diseases

Ley‐Zaporozhan¹,

Ley²,

Sommerburg³

et al. 2009

Fortschr Röntgenstr

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The standard examination technique for the chest in children is an X-ray examination - it is fast, cheap and provides a good overview of anatomy and pathology. In cases with an unclear pathology or if more details are needed (i. e. pre-therapeutically), computed tomography is most often performed with the well known drawbacks of limited soft tissue contrast and radiation. Radiation should be avoided in children, especially if follow-up examinations are needed. Recent magnetic resonance (MR) techniques allow for fast and reliable assessment of pulmonary diseases in children. Due to the inherent soft tissue contrast, diagnosis can be frequently performed without contrast media application. This review provides an exemplary MR examination protocol for routine application in pediatric patients. The diagnostic value of MRI is shown in patients with infectious diseases, patients with immunodeficiency, anatomic abnormalities, acquired chronic diseases, and pulmonary tumors. Since MRI is especially suitable for functional imaging, an MR protocol is provided for the examination of thoracic deformities. This review summarizes the use of thoracic MRI in the clinical pediatric setting with special focus on the clinical indications as a radiation-free method.

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Pulmonary MRI—a new approach for the evaluation of febrile neutropenic patients with malignancies

Abstract: MRI of the lungs is feasible in neutropenic patients with suspected pulmonary infection. Compared to HR-CT, MRI displays a high sensitivity in the detection of pulmonary infiltrates. MRI offers the opportunity of follow-up examinations without repeated X-ray exposure to the patient.

Cited by 44 publications

References 22 publications

MRI of pneumonia in immunocompromised patients: comparison with CT

MRI of pneumonia in immunocompromised patients: comparison with CT

Rapid lung MRI - paradigm shift in evaluation of febrile neutropenia in children with leukemia: a pilot study

Clinical Application of MRI in Children for the Assessment of Pulmonary Diseases

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