Early changes in serum creatinine level and estimated glomerular filtration rate predict pancreatic necrosis and mortality in acute pancreatitis

Lipiński, Michał; Rydzewski, Andrzej; Rydzewska, Grażyna

doi:10.1016/j.pan.2013.02.002

Cited by 34 publications

(35 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An elevation of serum creatinine has been used as a predictor of disease severity [23] and occurrence of pancreatic necrosis [24] as well as death [25]. The concentration of MMP-8 in serum has been shown to be elevated in septic children with AKI compared to those without AKI [26], but less is known about the relationship between MMP-8 and AKI in AP.…”

Section: Introductionmentioning

confidence: 99%

Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study

et al. 2016

View full text Add to dashboard Cite

ObjectivesSeveral biomarkers for early detection of severe acute pancreatitis (SAP) have been presented. Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are released early in inflammation. We aimed to assess levels of MMP-7, -8, -9 and TIMP-1 in acute pancreatitis (AP) and explore their ability to detect disease severity. Our second aim was to find an association between MMPs, TIMP and creatinine.MethodsWe collected plasma samples for MMP-7, -8, -9 and TIMP-1 analyses from 176 patients presenting within 96 h from onset of acute pancreatitis (AP) symptoms. We used samples from 32 control subjects as comparison. The revised Atlanta Classification was utilised to assess severity of disease. Receiver operating characteristic curve analysis and Spearman´s Rho-test were utilised for statistical calculations.ResultsCompared with controls, patients showed higher levels of all studied markers. MMP-8 was higher in moderately severe AP than in mild AP (p = 0.005) and MMP-8, -9 and TIMP-1 were higher in severe than in mild AP (p<0.001, p = 0.005 and p = 0.019). MMP-8 detected SAP with an AUC of 0.939 [95% CI 0.894–0.984], LR+ 9.03 [5.30–15.39]. MMP-8, -9 and TIMP-1 failed to discern moderately severe AP from SAP. MMP-7 was not different between patient groups. MMP-7 and TIMP-1 correlated weakly with creatinine (Rho = 0.221 and 0.243). MMP-8 might be a useful biomarker in early detection of SAP.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…6,14 However, urine level of NGAL (uNGAL), a parameter reflecting renal dysfunction more accurately and at earlier stage of the disease, has never been evaluated as a predictor of AP severity in humans. 6,14 However, urine level of NGAL (uNGAL), a parameter reflecting renal dysfunction more accurately and at earlier stage of the disease, has never been evaluated as a predictor of AP severity in humans.…”

mentioning

confidence: 99%

Urinary Neutrophil Gelatinase–Associated Lipocalin as an Early Predictor of Disease Severity and Mortality in Acute Pancreatitis

Lipiński¹,

Rydzewska–Rosołowska²,

Rydzewski³

et al. 2015

Pancreas

Self Cite

View full text Add to dashboard Cite

show abstract

“…NPV in predicting AP related in-hospital mortality. Renal impairment was an independent predictor for in-hospital mortality in patients with AP, and measurement of creatinine on the first day proved to be a good predictor of mortality [19] [20].…”

Section: Discussionmentioning

confidence: 93%

“…Thus, this new model may achieve early (within few hours of admission), simple and easily applicable tool to predict adverse outcomes in AP patients before using more sophisticated and expensive techniques. One reason for this superior predictive ability of this coupling model is the inclusion RDW and serum creatinine which are well-known predictors of mortality in AP as shown inprevious studies [13] [15] [19] [20]. This model has yet to be validated prospectively.…”

Section: Discussionmentioning

confidence: 99%

Early Predictors of Acute Pancreatitis Related In-Hospital Mortality: How Practical Are They?

Hassan¹,

Rehim²,

Kobeisy³

et al. 2018

OJGas

View full text Add to dashboard Cite

Background/Purpose: Early assessment of the severity of acute pancreatitis (AP) is a highly challenge for a physicians' practice to improve the management and decrease the mortality. We aimed to determine early prognostic factors for AP related in-hospital mortality. Methods: Upon hospital admission, predictors of AP related in-hospital mortality were prospectively assessed using regression analysis over 129 consecutive AP patients. Predictive abilities of these prognostic factors were compared using the area under receiver operating characteristic curve (AUC). Results: AP related in-hospital mortality was 10.9%. Red cell distribution (RDW), serum creatinine, glucose and albumin were associated with AP mortality. RDW had the highest AUC followed by serum creatinine and albumin (AUC: 914, 95% CI: 0.797-0.975; 0.797, 95% CI: 0.695-0.878; 0.798, 95% CI: 0.677-0.865 respectively). The cutoff with the best ability to predict in-hospital mortality was 14.2 for RDW. By coupling RDW and serum creatinine, AUC was improved to 0.940, 95% CI: 0.839-0.986. Conclusion: RDW, serum creatinine, albumin, and glucose even with borderline level changes may predict AP related in-hospital mortality, where, RDW has the highest prognostic accuracy. Coupling RDW and serum creatinine model significantly improves their predictive accuracy that may aid in further improvement of the quality of care of AP patients.

show abstract

Early changes in serum creatinine level and estimated glomerular filtration rate predict pancreatic necrosis and mortality in acute pancreatitis

Cited by 34 publications

References 17 publications

Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study

Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study

Urinary Neutrophil Gelatinase–Associated Lipocalin as an Early Predictor of Disease Severity and Mortality in Acute Pancreatitis

Early Predictors of Acute Pancreatitis Related In-Hospital Mortality: How Practical Are They?

Contact Info

Product

Resources

About