Early Cervical Neoplasia Confirmed by Conization

Objectives: Cervical cancer is a very common and lethal condition; however, owing to longstanding premalignant lesions, it is possible to prevent morbidity and mortality by screening tests. Pap smear, colposcopy, and biopsy are among the main modalities in this regard, however there is no consensus on the diagnostic utility of the first 2 methods. This study sought to examine the diagnostic utility of Pap smear, colposcopy, and cytology in evaluating the non-benign cervical lesions. Materials and Methods: A cross-sectional study was carried out between 2014 and 2016 in an out-patient setting at Alzahra teaching hospital of Tabriz University of Medical Sciences. After obtaining informed consent, all 315 participants with abnormal Pap test underwent colposcopy and biopsy from the abnormal areas. Cervical biopsy was considered as a gold standard and the diagnostic values of Pap smear and colposcopy were individually compared by calculating sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio. Results: The mean age of patients was 38.49±10.31 years (17-68 years). On the basis of biopsy findings, non-benign cervical lesions were present in 31 cases (9.8%). Accordingly, the sensitivity, specificity, positive predictive value, negative predictive value, and positive likelihood ratio of Pap smear in revealing non-benign cervical lesions were 77.4%, 69.7%, 21.8%, 95.6%, 70.7%, and 2.55%, and for colposcopy, were 90.3%, 90.9%, 51.9%, 98.9%, 90.8%, and 99.2%, respectively. Conclusions: Based on our results, the colposcopy is a sensitive and specific method in differentiating benign cervical lesions from non-benign cervical lesions. The accuracy of Pap smear is intermediate in this regard, and the utility is limited. Therefore, this method should not be considered as the main criterion for decision making.

show abstract

“…Similar to our study, previous reports also agreed upon the high accuracy of colposcopy in detecting non-benign cervical lesions (4,(22)(23)(24).…”

Section: Discussionsupporting

confidence: 92%

Diagnostic Value of Pap Smear and Colposcopy in Non-benign Cervical Lesions

Sayyah-Melli

Rahmani

Ouladsahebmadarek

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

View full text Add to dashboard Cite

show abstract

“…Overdiagnosis by cytology was detected in 6.1% of cases in the present study, which was similar to that of Matsuura et al (5%). [15] However, Mostafa et al noted a higher rate of 26%. False positive cases are mainly due to interpretive errors.…”

Section: *One Case Was Diagnosed As Hsil On Cytology and Was Consider...mentioning

confidence: 96%

Cytohistological Correlation Study of Conventional Papanicolaou Smears in Cervical Neoplasia

Kulkarni¹,

Hephzibah²

2013

Jrnl. of Res. Med. Edu. and Eths.

View full text Add to dashboard Cite

Context: Papanicolaou smear or Pap test is a widely accepted screening test to detect carcinoma cervix in early stages. In developed counties like United Kingdom, incidence of carcinoma cervix is decreasing by 3.5% every year mainly because of well-organised screening programmes. However, this is not true in India where incidence and mortality due to cervical cancer is increasing every year. Aims: The present study aims at evaluating the diagnostic accuracy of Pap smear in abnormal cervical smears and to analyse the factors responsible for discrepant cases. Methods: The histological diagnoses were correlated with cytology diagnoses and diagnostic accuracy of cytology was calculated considering histological diagnosis as gold standard. Results: Pap smear showed sensitivity of 88.23%, specificity of 92.5%, positive predictive value of 71.42% and diagnostic accuracy of 91.7% in the present study. Conclusion: The regular screening of women by Pap smear is a cost-effective method for early detection of premalignant and malignant cervical lesions and secondary prevention of carcinoma cervix.

show abstract

“…Dies führt sehr häufig zu unnöti-gen Behandlungen. Zum jetzigen Zeitpunkt ist dieses Konzept in der Schweiz nicht zu empfehlen, es sollte noch ausführlich geprüft werden [32,47,76,96] (Evidenz III).…”

Section: Patientinnenunclassified

“…Nach destruktiver Therapie sollte engmaschig, nach 3, 6 und 12 Monaten, nachkontrolliert werden [71,72,76,103,115,119]. Verlaufen alle Kontrollen negativ, so kann die Frau wieder ins übliche Vorsorgeprogramm aufgenommen werden.…”

Section: Nachkontrollen Nach Therapieunclassified

Guideline zum Vorgehen bei suspektem und positivem zytologischen Abstrich der Cervix uteri (überarbeitete Fassung, Version 2.4)

2004

Gynäkol Geburtshilfliche Rundsch

View full text Add to dashboard Cite

Early Cervical Neoplasia Confirmed by Conization

Cited by 20 publications

References 19 publications

Diagnostic Value of Pap Smear and Colposcopy in Non-benign Cervical Lesions

Diagnostic Value of Pap Smear and Colposcopy in Non-benign Cervical Lesions

Cytohistological Correlation Study of Conventional Papanicolaou Smears in Cervical Neoplasia

Guideline zum Vorgehen bei suspektem und positivem zytologischen Abstrich der Cervix uteri (überarbeitete Fassung, Version 2.4)

Contact Info

Product

Resources

About