Early Bone Formation at a Femur Defect Using CGF and PRF Grafts in Adult Dogs

Park, Hyun-Chun; Kim, Su-Gwan; Oh, Jaewon; You, Jun; Kim, Jae-Sung; Lim, Sung‐Chul; Jeong, Mi‐Ae; Kim, Jin-Son; Jung, Chan Min; Kwon, Yong-Ju; Ji, Hyeok

doi:10.1097/id.0000000000000423

Cited by 62 publications

(52 citation statements)

References 27 publications

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“…With regard to CGF, besides these effects, a direct effect on osteoblast proliferation 17 has been shown which results in early bone healing. 18 The present study corroborates these findings, as evidence of changes in bone density and area of radiolucency were seen as early as 1 month with the use of CGF in the periapical defects. Pertinently, such changes occur after 1 year for small, and more than one year for large periapical lesions that are left to heal spontaneously.…”

Section: Discussionsupporting

confidence: 90%

The use of Autologous Concentrated Growth Factors in Osseous Regeneration after Periapical Curettage: A Clinical Study

Hussain¹,

Jan²,

Behal³

2019

IJCMR

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Introduction: The contemporary research interest in autologous platelet concentrates is backed by an emerging evidence of their promising regenerative potential in number of clinical applications. Periapical inflammatory lesions represent a chronic pathology of the periapical tissues that result in considerable bone resorption and worsen the overall tooth prognosis. With this background, the present study was designed to evaluate the effect of the most recent platelet concentrate preparation, concentrated growth factors (CGF) on osseous regeneration after surgical management of periapical lesions. Material and methods: A prospective study was done in twenty patients where CGF was used to fill the periapical defects after periapical curettage. Area of radiolucency and mean gray values were assessed at baseline, 1 month, 3 months and 6 months after surgery using Image J software. Paired t-test was used to evaluate changes occurring between baseline and 1 month and baseline and 6 months. Results: And early and enhanced healing was evident form the substantial decrease in area of radiolucency, and mean grayscale values indicated a progressive increase in bone density during the observational period. These changes were highly significant (P< 0.05). Conclusion: CGF can be used as an efficacious and costeffective alternative to conventional bone substitutes for promoting healing after the surgical debridement of periapical defects.

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Section: Discussionsupporting

confidence: 90%

The use of Autologous Concentrated Growth Factors in Osseous Regeneration after Periapical Curettage: A Clinical Study

Hussain¹,

Jan²,

Behal³

2019

IJCMR

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“…reported that A‐PRF have a slimmer and more disorganized fibrin network. Judging from other investigators’ data, it is thought that the alternated speeds of CGF might affect the agglutination of platelets, fibrinogen, factor XIII, and thrombin which facilitate the conversion of fibrinogen to fibrin and the polymerization of the fibrin . This highly cohesive fibrin matrix provides protection from plasmin degradation, resulting in higher fibrin tensile strength and stability .…”

Section: Discussionmentioning

confidence: 99%

“…Since the preparation protocols share the same principle of clot formation, it seems interesting to distinguish between the characteristics of A‐PRF and CGF. Although the growth factor contents in A‐PRF and CGF clots and their bioactivities have been demonstrated separately in numerous studies by independent group, the exact differences between these two materials have not been clearly studied and published scientifically. In clinical settings, both A‐PRF and CGF have been applied as membranes and/or combined with various biomaterials such as collagen membranes and/or bone grafts to facilitate wound healing and tissue regeneration .…”

Section: Introductionmentioning

confidence: 99%

Quantification of growth factors in advanced platelet‐rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects

Lei

Han

et al. 2019

Journal of Periodontology

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Background:The development of platelet concentrated biomaterials has gained increasing awareness for regenerative medicine. With different protocol, derivatives such as advanced platelet-rich fibrin (A-PRF), injected platelet-rich fibrin, and concentrated growth factor (CGF) have been demonstrated effectively in preclinical and clinical studies. The aim of this study was to compare the level of growth factors releasing from A-PRF and CGF, and their clinical efficacy in the regenerative management of intrabony defects (IBDs).Methods: Thirty-two blood samples were collected from eight healthy donors and assessed for platelet-derived growth factor-, vascular endothelial growth factor, bone morphogenetic protein-2, and transforming growth factor-1 release at indicated times. In addition, the clinical records of 45 patients (15 per group) who had undergone guided tissue regeneration (GTR) with or without A-PRF/CGF were retrieved. The probing depth (PD) and clinical attachment level (CAL) were recorded preoperatively and 6 months postoperatively. Intrabony component (IC) depth, radiographic bone level (RBL), and bone defect filling were assessed radiographically. Results:A-PRF had a looser fibrin network than the CGF but presented larger amounts of growth factors with a more sustained release period. Although there was no difference in PD reduction, CAL gain, RBL height change and defect filling (%) between A-PRF and CGF group, both achieved a more favorable clinical result in IC height reduction and defect filling (%) than the control. Conclusions:A-PRF and CGF have the ability to stimulate a continual and steady release of total growth factors over a 14-day period. A-PRF and CGF show a similar effectiveness in periodontal bone regeneration with a potential benefit of improving GTR outcomes in IBD treatment. K E Y W O R D Sbone substitutes, growth factors, guided tissue regeneration, periodontitis, platelet-rich fibrin 462

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“…Aynı zamanda vasküler dayanıklılık, neovaskülarizasyon ve anjiogenezde rol alan CD34+ kök hücre içermektedir (15,23). CGF'in yumuşak doku iyileşmesinde PRP'ye göre daha etkili olduğu raporlanmıştır (24). Sonuçta önceki çalışmalarda CGF'in inflamasyona aracılık ettiği, hücre proliferasyonunu arttırdığı ve doku onarımını indüklediği belirtilmiştir.…”

Section: Cerrahi Teknikunclassified

Konsantre büyüme faktörünün random patern cilt flep yaşayabilirliği üzerine etkisi: deneysel çalışma

Gürsoy

Koca

Alişik

et al. 2020

Journal of Health Sciences and Medicine

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Introduction: Random pattern skin flaps are used frequently for the reconstruction of random pattern skin defects from various causes in plastic and reconstructive surgery. Most frequent complication with these flaps is the necrosis of distal parts due to inadequate blood supply. Various types of techniques have been defined to avoid and reduce flap loss. The aim of this study is, for the first time, to evaluate the effect of concentrated growth factor (CGF), which is derived from whole blood and is rich in growth factors, on the survival of random pattern skin flaps. Material and Method: Fifty Sprague-Dawley rats were used for the study. Forty of them were used for the experiment group and ten for the preparation of CGF. Distal based 3x9 cm McFarlene flaps were elevated from the back of the rats and in CGF group (n:20), CGF matrix was placed before closure. No treatment was given to the control group (n:20). On postoperative day 7, the flaps were evaluated by photographic, scintigraphic, and histopathological methods. Results: The median rate of surviving flap areas in control group was 53% (47-58). In CGF group the median rate of flap viability was %58 (55-64). The higher flap viability rates obtained from CGF applied group was found to be statistically significantly higher from control group (p<0,001). For the scintigraphic perfusion area evaluations, the median rate of flap perfusion was 54% (51-60) for the control group and 61% (59-64) for the CGF group. The higher flap perfusion rates obtained from CGF applied group was found to be statistically significantly higher from control group (p=0,001). The median rate of vascularity scores in CGF treated group was 10,0 (8,25-11,75) and 7,5 (6,25-9,00) in control group. The difference was found to be statistically significantly higher in the study group (p=0,003). Inflammation scores were not found to be statistically significantly different (p=0,246). Conclusions: This study shows that locally applied CGF under skin flap increases flap viability which might be associated with the increase in angiogenesis. This study for the first time shows that in flap surgery, applying CGF which is rich in growth factors, might have favorable effects on the flaps that are prone to ischemia but further studies are needed.

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Early Bone Formation at a Femur Defect Using CGF and PRF Grafts in Adult Dogs

Cited by 62 publications

References 27 publications

The use of Autologous Concentrated Growth Factors in Osseous Regeneration after Periapical Curettage: A Clinical Study

The use of Autologous Concentrated Growth Factors in Osseous Regeneration after Periapical Curettage: A Clinical Study

Quantification of growth factors in advanced platelet‐rich fibrin and concentrated growth factors and their clinical efficacy as adjunctive to the GTR procedure in periodontal intrabony defects

Konsantre büyüme faktörünün random patern cilt flep yaşayabilirliği üzerine etkisi: deneysel çalışma

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