Early bone formation around immediately loaded implants with nanostructured calcium-incorporated and machined surface: a randomized, controlled histologic and histomorphometric study in the human posterior maxilla

Mangano, Francesco; Iezzi, Giovanna; Shibli, Jamil Awad; Pires, Jefferson Trabach; Luongo, Giuseppe; Piattelli, Adriano; Mangano, Carlo

doi:10.1007/s00784-017-2061-y

Cited by 24 publications

(40 citation statements)

References 32 publications

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“…Several authors have suggested that primary stability may be a useful predictor for osseointegration [29][30][31][32][33][34][35] and that a high primary stability makes immediate loading more predictable [19,20,26,27] [32]. In fact, in that study, no implant with ISQ > 60 failed, while 19% of implants with ISQ < 60 failed [32].…”

Section: Discussionmentioning

confidence: 90%

“…The surface of these implants was the result of a sandblasting treatment (resorbable blast media) and the subsequent incorporation of calcium ions by means of a hydrothermal treatment [28]. This nanotopographical surface (Xpeed5, Megagen, Gyeongsang, South Korea) is characterized by increased surface area/energy, for a better interaction with biological fluids, and therefore has the potential to stimulate and accelerate osseointegration [28,29]. Finally, from the prosthetic point of view, such fixtures possess a 5 mm deep conical connection (10 ∘ ) combined with an internal hexagon, capable of ensuring high mechanical stability and a suitable biological seal; an integrated switching platform is present, to maintain peri-implant tissue volume over time [19,20].…”

Section: Dental Implantsmentioning

confidence: 99%

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Implant stability in the posterior maxilla: a controlled clinical trial

Gomes¹

2017

http://isrctn.com/

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Aim. To evaluate the primary and secondary stability of implants in the posterior maxilla. Methods. Patients were allocated into three groups: (A) native bone, (B) partially regenerated bone, and (C) nearly totally regenerated bone. Insertion torque (IT) and implant stability quotient (ISQ) were measured at placement, to evaluate whether satisfactory high primary stability (IT ≥ 45 N/cm; ISQ ≥ 60) was achieved; ISQ was measured 15, 30, 45, and 60 days after placement, to investigate the evolution to secondary stability. Results. 133 implants (Anyridge5, Megagen) were installed in 59 patients: 55 fixtures were placed in Group A, 57 in Group B, and 21 in Group C. Fifty-two implants had satisfactory high primary stability (IT ≥ 45 N/cm; ISQ ≥ 60). A positive correlation was found between all variables (IT, ISQ at t = 0, t = 60), and statistically higher IT and ISQ values were found for implants with satisfactory high primary stability. Significant differences were found for IT and ISQ between the groups (A, B, and C); however, no drops were reported in the median ISQ values during the healing period. Conclusions. The evaluation of the primary and secondary implant stability may contribute to higher implant survival/success rates in critical areas, such as the regenerated posterior maxilla. The present study is registered in the ISRCTN registry with ID ISRCTN33469250.

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Section: Discussionmentioning

confidence: 90%

Section: Dental Implantsmentioning

confidence: 99%

Implant stability in the posterior maxilla: a controlled clinical trial

Gomes¹

2017

http://isrctn.com/

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“…With this procedure, a nanolayer of Ca 2+ ions is incorporated onto the RBM surface, giving a CaTiO 3 nanostructure. Previous studies [24,32,33] have reported the following standard roughness parameters for this surface: a mean Ra (the arithmetic mean of the absolute height of all points) of 1.6 (±0.2) µm, a mean Rq (the square root of the sum of the squared mean difference of all points) of 2.1 (±0.3) μm, and a mean Rt (the difference between the highest and lowest points) of 15.7 (±0.2) μm. …”

Section: Methodsmentioning

confidence: 99%

“…The Xpeed ® surface (Megagen, Seoul, South Korea) is a nanostructured surface enriched with calcium ions through a hydrothermal method [24,32,33]. Histological and histomorphometrical studies on humans have confirmed that this nanostructured surface can support new bone formation, under an immediate loading protocol [32,33].…”

Section: Introductionmentioning

confidence: 99%

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Scanning Electron Microscope (SEM) Evaluation of the Interface between a Nanostructured Calcium-Incorporated Dental Implant Surface and the Human Bone

et al. 2017

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Purpose. The aim of this scanning electron microscope (SEM) study was to investigate the interface between the bone and a novel nanostructured calcium-incorporated dental implant surface in humans. Methods. A dental implant (Anyridge®, Megagen Implant Co., Gyeongbuk, South Korea) with a nanostructured calcium-incorporated surface (Xpeed®, Megagen Implant Co., Gyeongbuk, South Korea), which had been placed a month earlier in a fully healed site of the posterior maxilla (#14) of a 48-year-old female patient, and which had been subjected to immediate functional loading, was removed after a traumatic injury. Despite the violent trauma that caused mobilization of the fixture, its surface appeared to be covered by a firmly attached, intact tissue; therefore, it was subjected to SEM examination. The implant surface of an unused nanostructured calcium-incorporated implant was also observed under SEM, as control. Results. The surface of the unused implant showed a highly-structured texture, carved by irregular, multi-scale hollows reminiscent of a fractal structure. It appeared perfectly clean and devoid of any contamination. The human specimen showed trabecular bone firmly anchored to the implant surface, bridging the screw threads and filling the spaces among them. Conclusions. Within the limits of this human histological report, the sample analyzed showed that the nanostructured calcium-incorporated surface was covered by new bone, one month after placement in the posterior maxilla, under an immediate functional loading protocol.

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Study on the difference of osteogenesis and Notch signaling pathway expression in biphasic calcium‐phosphorus ceramic granule materials with different microstructure

et al. 2022

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Different microstructures including micropore diameter, micropore volume, and micropore area of biphasic calcium phosphate (BCP, hydroxyapatite: β-tricalcium phosphate = 8:2) ceramics granules were obtained by varying their sintering temperatures. Sprague-Dawley rat bone marrow-derived stem cells (BMSCs) were co-cultured with BCPs in vitro study and the BMSCs showed different degrees of proliferative activity under the influence of three materials. Cell proliferation and vitality were assessed. Three kinds of BCPs were implanted in the dorsal muscle of beagle dogs.At 1, 2, and 3 months, histological analyses were conducted to estimate the rate of osteogenesis. Expression of Notch pathway genes and osteogenic-related genes were detected by quantitative real-time polymerase chain reaction (q-rtPCR). The proportion of osteogenesis area increased to:48.75 ± 4.20%, 29.48 ± 1.55%, and 26.58 ± 3.86% at 3 months after the implantation (1050, 1150, 1250). Significant differences were observed in the upregulation of Notch pathway genes among different BCPs. BCPs with different micropore diameters have different ectopic osteogenesis effects and led to up-regulation of the Notch signaling pathway genes to different extents.

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Early bone formation around immediately loaded implants with nanostructured calcium-incorporated and machined surface: a randomized, controlled histologic and histomorphometric study in the human posterior maxilla

Cited by 24 publications

References 32 publications

Implant stability in the posterior maxilla: a controlled clinical trial

Implant stability in the posterior maxilla: a controlled clinical trial

Scanning Electron Microscope (SEM) Evaluation of the Interface between a Nanostructured Calcium-Incorporated Dental Implant Surface and the Human Bone

Study on the difference of osteogenesis and Notch signaling pathway expression in biphasic calcium‐phosphorus ceramic granule materials with different microstructure

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