Early Assessment of Response to Radiofrequency Ablation With CT Perfusion Imaging in Rabbit VX2 Liver Tumor Model

Abstract

ObjectivesTo discriminate viable tumors from benign periablational enhancement (BPE) in early stage after radiofrequency ablation (RFA) is a major confounding problem. The goal of this study is to evaluate quantitative assessment and diagnostic value of CT perfusion between viable tumors and BPE after RFA in the rabbit liver VX2 tumor model, with pathological results as the standard.MethodsTwenty-eight VX2 liver tumors were treated with RFA, on days 1, 3, 7, and 14, seven rabbits were randomly chosen for CT perfusion and performed pathology examinations immediately. The perfusion parameters along with the profile of time-density curves (TDCs) and pseudo-color images of the parameters were observed in both BPE and viable tumors, then compared with the pathology results. The perfusion parameters included blood flow (BF), blood volume (BV), time to peak (TTP), permeability (P), arterial liver perfusion (ALP), portal venous perfusion (PVP) and hepatic perfusion index (HPI).ResultsA total of 26/28 rabbits successfully underwent CT perfusion, while 6/26 lesions were confirmed to be viable tumors. The TDCs of BPE were mainly speed-up platform curves (15/26), while the viable tumors showed mainly speed-up speed-down (3/6) and speed-up platform (2/6) curves. The PVP values were significantly higher, and the HPI values were significantly lower for BPE at all time points than viable tumors (P < 0.05). Both of PVP value and HPI value have high efficiency for the differential diagnosis of the viable tumors and BPE at each time point. These characteristics of CT perfusion parameters were consistent with pathological changes.ConclusionsThe TDCs, PVP and HPI have the potential to indicate BPE and viable tumors effectively early after RFA treatment, the results were highly consistent with pathology. CT perfusion has advantages with great efficacy in monitoring the therapeutic effect early after RFA treatment.

Advances in The Application and Research of Magnetic Resonance Diffusion Kurtosis Imaging in The Musculoskeletal System

“…Moreover, it closely mimics the biological behavior of human malignant bone tumors. 52,53 MK and MD can measure the non-Gaussian distribution of water molecule displacements as typical markers of DKI models, which can be utilized to discriminate between regions with micro-infiltration and simple edema in malignant bone tumors and for postradiotherapy evaluation. 20,21,54 DKI enables sensitive examination of malignant bone tumors in animal models without being affected by microinfiltration or simple edema.…”

“…Construction of this model is relatively simple, and its biological properties are stable, the proliferation after planting is rapid, and distant metastasis can occur in a short duration of time. Moreover, it closely mimics the biological behavior of human malignant bone tumors 52,53 . MK and MD can measure the non‐Gaussian distribution of water molecule displacements as typical markers of DKI models, which can be utilized to discriminate between regions with micro‐infiltration and simple edema in malignant bone tumors and for postradiotherapy evaluation 20,21,54 …”

Prediction of adenocarcinoma and squamous carcinoma based on CT perfusion parameters of brain metastases from lung cancer: a pilot study

“…CT perfusion imaging is a noninvasive functional imaging technique that reflects the hemodynamic changes in tumors with the foundation of enhanced CT ( 5 , 6 ). In comparison to magnetic resonance imaging (MRI) perfusion imaging, it is insensitive to paramagnetic susceptibility artifacts, is more accessible, has shorter examination times, and has better patient tolerance.…”