Early and mid-term outcomes in female patients undergoing isolated conventional coronary surgery

Ergüneş, Kazım; Yilik, Levent; Yetkin, Ufuk; Lafci, Banu; Bayrak, Serdar; Özpak, Berkan; Gürbüz, Ali

doi:10.5681/jcvtr.2014.023

Cited by 5 publications

(1 citation statement)

References 20 publications

(32 reference statements)

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“…Besides, a meta-analysis of 20 studies showed that women had an increased risk of short-, mid-, and long-term mortality after isolated CABG compared to men [ 24 ]. Another study conducted by Ergunes et al found that the in-hospital mortality rate was higher in female patients however, the mid-term survival was similar between males and females [ 25 ]. However, according to our results, the female gender was not associated with an increased risk of mortality.…”

Section: Discussionmentioning

confidence: 99%

Significance of preoperative left ventricular ejection fraction in 5-year outcome after isolated CABG

Fallahzadeh

Sheikhy

Ajam

et al. 2021

J Cardiothorac Surg

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Background Pre-operative ejection fraction (EF) and comorbidities affect post-op outcomes. We aimed to compare the mortality and adverse events of patients with different baseline EF and also to evaluate the distribution of comorbidities in each EF group. Methods A total of 20,937 patients who underwent isolated coronary artery bypass graft (CABG) surgery from January 2006 to December 2016 was included. Patients were divided into three groups based on their pre-operative left ventricular EF as follows; (1) Normal: EF ≥ 50%; (2) Mild to moderately reduced: 50% < EF ≤ 35%; and (3) Severely reduced: EF < 35%. The backward elimination method was considered for multivariate Cox-regression analysis to locate predictors of mortality and non-fatal cerebro-cardiovascular events (CCVEs). The median follow-up time was 5.61 [3.12–8.0] years. Results The mean age in the total population was 60.94 ± 9.51 years and 73.6% of the total population was male. Diabetes mellitus was the common risk factor of mortality and CCVE in all EF groups. Impaired renal function (GFR < 60 ml/min) was associated with a higher risk of mortality after CABG regardless of EF level. The median 5-year mortality rate in patients with normal EF, mild-moderately reduced EF and severely reduced EF were 9.5%, 12.8%, and 22.7% respectively (P < 0.001). Although the trend of CCVEs was higher in severe left ventricle (LV) dysfunction, it was not statistically significant (p = 0.071). Conclusion Patients with severely reduced EF are at higher risk of mortality after CABG compared to those with higher EF levels; however, the rate of CCVEs may not be necessarily higher after adjustment for multiple pre-operative comorbidities.

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Section: Discussionmentioning

confidence: 99%

Significance of preoperative left ventricular ejection fraction in 5-year outcome after isolated CABG

Fallahzadeh

Sheikhy

Ajam

et al. 2021

J Cardiothorac Surg

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Coronary artery bypass grafting in South Asian patients: Impact of gender

Khan

Shahabuddin

Khan

et al. 2016

Annals of Medicine &Amp; Surgery

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BackgroundOutcomes following Coronary artery bypass grafting (GABG) vary between genders, with females having a higher postoperative mortality than males. Most of the studies are on Caucasian or mixed population and it is postulated that Asian population and in particular women have higher morbidity and mortality. In this study we have compared outcomes of elective CABG in men and women of South Asian origin in terms of morbidity and mortality.MethodsFrom January 2006 to December 2012, 1970 patients underwent isolated elective CABG at the Aga Khan University Hospital, Pakistan were selected. The prospectively collected data was analyzed retrospectively including univariate and multivariate analysis to find the association of morbidity and mortality.ResultsAmong the study patients 1664 (85%) were male and 306 (15%) female. Hypertension and diabetes were the most common comorbid conditions seen preoperatively in female patients. Atrial fibrillation and sepsis were the most common postop complications seen in females. In hospital mortality was 3.9% in female underwent CABG as against 0.6% in male. Multivariate analysis showed older age, renal failure, dyslipidemia and prolonged cross clamp time as predictors of postoperative morbidity. Multivariate analysis showed female gender, age and renal failure as predictors of in hospital mortality.ConclusionsFemale gender is an independent risk factor for postoperative mortality following CABG however, female gender is not found to be independent risk factor for morbidity. The trend of higher mortality in female patients was comparable to most studies done on Caucasian patients.

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Sex Differences in the Epidemiology of New-Onset In-Hospital Post–Coronary Artery Bypass Graft Surgery Atrial Fibrillation

Filardo

Ailawadi

Pollock

et al. 2016

Circ: Cardiovascular Quality and Outcomes

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Background-New-onset atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG) is associated with increased morbidity and poorer long-term survival. Although many studies show differences in outcome in women versus men after CABG, little is known about the sex-specific incidence and characteristics of post-CABG AF. . At 48 hours, AFfree probabilities were 77% for women and 72% for men (P<0.001). Number of episodes (P=0.18), operative mortality (P=0.048), stroke (P=0.126), and discharge in AF (P=0.234) did not differ significantly by sex. Conclusions-These novel data on sex-specific characteristics of new-onset AF after isolated CABG show that women had lower adjusted risk for post-CABG AF and experienced shorter episodes. Investigation of sex-specific impacts on outcomes is needed to identify optimal strategies for prevention and management to ensure all patients achieve the best possible outcomes. (Circ Cardiovasc Qual Outcomes. 2016;9:723-730.

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Early and mid-term outcomes in female patients undergoing isolated conventional coronary surgery

Cited by 5 publications

References 20 publications

Significance of preoperative left ventricular ejection fraction in 5-year outcome after isolated CABG

Significance of preoperative left ventricular ejection fraction in 5-year outcome after isolated CABG

Coronary artery bypass grafting in South Asian patients: Impact of gender

Sex Differences in the Epidemiology of New-Onset In-Hospital Post–Coronary Artery Bypass Graft Surgery Atrial Fibrillation

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