Early and Late Recurrence After Liver Resection for Hepatocellular Carcinoma

Abstract

Early and late recurrences are linked to different predictive factors. The modality of presentation of the recurrence together with the feasibility of a radical treatment are the best determinants for the prognosis.

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

“…In our study, we found that the degree of liver cirrhosis is the only significant risk factor for postoperative late intrahepatic recurrence. This finding was consistent with previous reports (Poon et al, 2000;Portolani et al, 2006). Poon et al (2000) investigated 246 HCC patients underwent curative resection and identified cirrhosis as the only significant risk factor for late recurrence.…”

“…Liver cirrhosis is established through repetitive necroinflammation and regeneration. Several investigators have also reported that liver cirrhosis is significant risk factor for recurrence after resection for HCC (Portolani et al, 2006;Sumie et al, 2008;Ho et al, 2012). In our study, we found that the degree of liver cirrhosis is the only significant risk factor for postoperative late intrahepatic recurrence.…”

“…Poon et al (2000) investigated 246 HCC patients underwent curative resection and identified cirrhosis as the only significant risk factor for late recurrence. Portolani et al also found that cirrhosis was independently related to the recurrence in their study containing 213 patients (Portolani et al, 2006). These results suggested that the presence of cirrhosis play an important role in late intrahepatic recurrence for HCC patients after resection.…”

“…Previous studies have identified various risk factors for early and late recurrence in patients with HCC. Early recurrence after resection for HCC is likely to be associated with aggressive tumor biology , especially macro or microscopic vascular infiltration (Portolani et al, 2006;Wu et al, 2009), whereas late recurrence is likely to be associated with the presence of cirrhosis (Poon et al, 2000;Portolani et al, 2006) and hepatitis virus infection (Wu et al, 2009;Muscari et al, 2011). Most of the them were performed in unselected patients ,including patients with macrovascular invasion and/or multiple tumors.…”

Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma

“…In contrast, our univariate analysis showed increased levels of cfDNA in HCC patients with early IHR. Most early IHRs can be attributed to intrahepatic metastasis of cancer cells and are detected in 30 -50% of patients within 1 or 2 years after surgery, limiting the potential for surgical cure of HCC (Tung-Ping Poon et al, 2000;Iizuka et al, 2003;Llovet et al, 2003;Matoba et al, 2005;Portolani et al, 2006). Thus, the increased levels of serum cfDNA are related to the high metastatic potential, but not to the appearance of de novo tumour, of this type HCC.…”