Early- and late-onset psoriasis: a cross-sectional clinical and immunocytochemical investigation

Theodorakopoulou, Eleni; Yiu, Zenas Z N; Bundy, Christine; Chularojanamontri, Leena; Gittins, Matthew; Jamieson, Lynne; Motta, Luisa; Warren, Richard B; Griffiths, C.E.M.

doi:10.1111/bjd.14886

Cited by 34 publications

(43 citation statements)

References 27 publications

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“…Two distinct subtypes of chronic plaque psoriasis were proposed: early onset psoriasis (presenting in patients aged ≤40 years) and late onset psoriasis (presenting in those aged >40 years) . The early onset psoriasis was reported to be associated with type 2 diabetes and autoimmune thyroiditis . However, in our survey, there was no difference in the ratio of diabetes between early onset psoriasis and late onset psoriasis, and it is unapparent whether the two psoriasis subtypes are different in concomitant disorders.…”

Section: Discussioncontrasting

confidence: 54%

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Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan

Ogawa

Okuyama

Seki

et al. 2017

The Journal of Dermatology

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A local epidemiological survey of psoriasis was conducted from 19 February to 30 June 2016 in Matsumoto city, Nagano Prefecture, Japan. Patients were predominantly male (268 cases, 71.5% males vs 107 cases, 28.5% females). We estimated that the prevalence of psoriasis was 0.097% in the Matsumoto area. The clinical types of psoriasis identified were psoriasis vulgaris (90.7%), psoriatic arthritis (5.9%), pustular psoriasis (2.1%), guttate psoriasis (1.0%) and psoriatic erythroderma (0.3%). The topical therapeutic agents included corticosteroids (84.0%), vitamin D analogs (61.5%), and a combination of calcipotriol and betamethasone dipropionate (31.0%). Current systemic treatments included cyclosporin (9.0%), etretinate (7.4%) and methotrexate (1.3%). Biologic treatments included adalimumab (4.0%), ustekinumab (2.7%), infliximab (1.3%) and secukinumab (0.8%). Ultraviolet B therapy (11.3%) was the predominant phototherapy in which narrow band ultraviolet B therapy accounted for the majority, followed by psoralen and ultraviolet A therapy (1.0%). According to the recent evolution of psoriasis treatment, the use of biologics has been increasing. This study demonstrates the changes of treatment trends of psoriasis in a non-metropolitan regional area.

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Section: Discussioncontrasting

confidence: 54%

“…7 The early onset psoriasis was reported to be associated with type 2 diabetes and autoimmune thyroiditis. 8 However, in our survey, there was no difference in the ratio of diabetes between early onset psoriasis and late onset psoriasis, and it is unapparent whether the two psoriasis subtypes are different in concomitant disorders.…”

Section: Discussionmentioning

confidence: 51%

Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan

Ogawa

Okuyama

Seki

et al. 2017

The Journal of Dermatology

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“…The changes in the immunological status are critical in the induction of inflammatory diseases such as psoriasis and an increase in the ratio of CD4 + /CD8 + T cells has been found in early as well as in late phases of psoriasis [105]. In Koebner-positive patients also, a change in the ratio of CD4 + /CD8 + cells has been identified in the epidermis as well as in dermis portions in untraumatized and uninvolved skin portions of psoriatic patients.…”

Section: Changes In the Ratio Of Cd4 + /Cd8 + Cellsmentioning

confidence: 99%

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Liu

2019

Bioscience Reports

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Koebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggest that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections and striae etc. The different mechanisms that contribute in inducing the development of new psoriatic lesions as Koebernization include the involvement of mast cell-derived inflammatory mediators such as tryptase, IL-6, IL-8, IL-17, and IL-36γ. Moreover, an increased expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) also contribute in Koebernization. Apart from these, there is a critical role of α 2 β1 integrins, S100A7 (psoriasin) and S100A15 (koebnerisin), change in the ratio of CD4+/CD8+ T cells, down-regulation of mechanosensitive polycystin 1 protein, decrease in inflammation controlling atypical chemokine receptor 2 (ACKR2), reduced expression of N-methyl-d-aspartate (NMDA) receptors (NMDARs) on the keratinocytes and increase in levels of chemokines (CXCL8 and CCL20) in inducing formation of new psoriatic lesions. The present review discusses the role of Koebner phenomenon in the development of new psoriatic lesions. Moreover, it also describes the mechanisms involved in Koebernization in the form of discussion of different key targets that may be potentially modulated pharmacologically to attenuate/halt the development of new psoriatic lesions.

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“…The study by Theodorakopoulou and colleagues in this edition of the British Journal of Dermatology provides further evidence of the differences between EOP and LOP . This study assessed clinical, psychological and immunohistochemical parameters between patients with EOP (< 40 years of age) and LOP (> 40 years of age).…”

mentioning

confidence: 99%

Is late-onset psoriasis a distinct subtype of chronic plaque psoriasis?

Kirby

2016

Br J Dermatol

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Early- and late-onset psoriasis: a cross-sectional clinical and immunocytochemical investigation

Abstract: Our findings provide further evidence for the difference between EOP and LOP.

Cited by 34 publications

References 27 publications

Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan

Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan

Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

Is late-onset psoriasis a distinct subtype of chronic plaque psoriasis?

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