Is late-onset psoriasis a distinct subtype of chronic plaque psoriasis?

Kirby, Brian

doi:10.1111/bjd.15035

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…However, we found LOP was significant associated with anxiety and depression, but no significant correlation was observed in EOP. The explanation of our results may be that LOP patients were more commonly reported the symptoms of itching, sensitive skin, and burning and worry about the disease, which can result in psychological burdens (32). Moreover, LOP patients were common with chronic inflammatory comorbidities, such as type 2 diabetes, obesity, autoimmune thyroiditis, which can reduce the quality of life and increase the cost of treatment (33,34).…”

Section: Discussionmentioning

confidence: 87%

Association of Psoriasis With Anxiety and Depression: A Case–Control Study in Chinese Patients

Jing

Shen

et al. 2021

Front. Med.

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Background: Patients with psoriasis are prone to suffer from anxiety and depression during their lifetime. This study aimed to investigate the association of psoriasis with anxiety and depression in Chinese patients.Methods: A case-control study in Chinese patients with psoriasis vulgaris and healthy controls was conducted. Clinical information based on patient-reported, clinical information, and reliable structured questionnaires were collected. Multivariable logistic regression was used to investigate the associations, in terms of adjusted odds ratios (AORs).Results: We continuously selected 1,571 patients who were firstly diagnosed with psoriasis vulgaris, and 1,571 healthy controls, matched by age and sex. The risk of depression in the psoriasis vulgaris group was higher than that in the healthy controls (AOR = 1.30, P = 0.047), while no differences were found in the risk of anxiety between the two groups (AOR = 1.18, P = 0.381). Subgroup analysis by disease onsets showed that late-onset psoriasis (LOP) was significantly associated with a higher risk of anxiety (AOR = 1.47, P = 0.033) and depression symptoms (AOR = 1.85, P = 0.012) but not with early-onset psoriasis (EOP). Subgroup analysis by disease severity indicated that no difference was observed in the associations of mild psoriasis vulgaris, moderate-to-severe psoriasis vulgaris with anxiety and depression.Conclusion: Patients with psoriasis vulgaris were more likely to develop depression compared with the general population. LOP patients were positively associated with anxiety and depression. We believe the screening of emotional disorders should be included in the daily management of psoriasis patients.

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Section: Discussionmentioning

confidence: 87%

Association of Psoriasis With Anxiety and Depression: A Case–Control Study in Chinese Patients

Jing

Shen

et al. 2021

Front. Med.

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“…Finally, using a relatively low age cut-off (20 years old), a cross-sectional study reported that patients with EOP were significantly more anxious than those with LOP (83), although the reverse has been reported by other studies (76,78,82). Depression levels and their relationship to age of onset require further investigation as the results are conflicting (78,(82)(83)(84), which could be attributed to differences in the age cut-off levels and the use of different measures of depression (76). Also, the subjective perception of individuals about their condition and its impact might be different between EOP and LOP (85).…”

Section: Late-versus Early-onset Psoriatic Arthritis and Psoriasis Di...mentioning

confidence: 88%

“…People with LOP were less likely to be on treatment with biologics (78), which was even more noticeable in those with very late onset psoriasis (>70 years old) (81). Furthermore, post hoc analysis of data from four clinical trials of etanercept for psoriasis reported that treatment was more effective in patients with EOP compared to those with LOP (76,82). Finally, using a relatively low age cut-off (20 years old), a cross-sectional study reported that patients with EOP were significantly more anxious than those with LOP (83), although the reverse has been reported by other studies (76,78,82).…”

Section: Late-versus Early-onset Psoriatic Arthritis and Psoriasis Di...mentioning

confidence: 99%

“…Furthermore, post hoc analysis of data from four clinical trials of etanercept for psoriasis reported that treatment was more effective in patients with EOP compared to those with LOP (76,82). Finally, using a relatively low age cut-off (20 years old), a cross-sectional study reported that patients with EOP were significantly more anxious than those with LOP (83), although the reverse has been reported by other studies (76,78,82). Depression levels and their relationship to age of onset require further investigation as the results are conflicting (78,(82)(83)(84), which could be attributed to differences in the age cut-off levels and the use of different measures of depression (76).…”

Section: Late-versus Early-onset Psoriatic Arthritis and Psoriasis Di...mentioning

confidence: 99%

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Does Age Matter in Psoriatic Arthritis? A Narrative Review

et al. 2021

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Psoriatic arthritis (PsA) affects about 0.8% of the general population. Together with psoriasis is termed psoriatic disease. Comorbidities play an important role in the clinical expression and treatment of psoriatic disease. Ageing adds another level of complexity, partly because age directly accrues increasing risk of comorbidities, but also due to its complex interactions with several factors such as depression and social determinants. Ageing seems to have a "paradoxical association" with cardiovascular comorbidities for which the relative risk is more pronounced in younger patients with psoriatic disease and also to affect treatment decisions and response in patients with psoriatic disease. Finally, there is convincing evidence that there are clinical, genetic and histopathological differences between young- and late- onset PsA and psoriasis. Herein, we review the effect of age in patients with psoriatic disease, with a focus on PsA, highlighting the need to consider this feature in routine clinical practice as well as in the research domain.

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“…Early-onset psoriatic patients carriers of the HLA-Cw6 allele and late-onset psoriatic patients are characterized by clinical, demographic, immunocytochemical and genetic differences [53, 54]. Our results are incorporated in the above setting of the two distinct subtypes of psoriasis vulgaris [55].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Gap Junction Protein Beta-2 rs3751385 Gene Polymorphism in Psoriasis Vulgaris

et al. 2019

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Background Gap junction protein beta 2 (GJB2) upregulation in psoriasis transcriptome analysis as well as connexin 26 (Cx26, encoded by GJB2) expression upregulation in psoriatic plaques has already been substantiated. GJB2 rs72474224 and rs3751385 have been correlated with psoriasis vulgaris incidence in Chinese populations. Here we study the effect of rs3751385 in patients suffering from psoriasis vulgaris in a Caucasian Greek population at the prefecture of Thrace in Northern Greece. Methods One hundred and seventy-three (111 males and 62 females) psoriatic patients (108 were of early-onset psoriasis) and 171 matched controls were included in the study. Genomic DNA was extracted from peripheral blood leukocytes and genotyping was carried out by polymerase chain reaction-restriction-fragment length polymorphism (PCR-RFLP). Results A statistically significant lower frequency of C/T genotype in late-onset male psoriasis vulgaris (P = 0.029) as well as of T allele in female early-onset psoriasis vulgaris (P = 0.049) were ascertained. Conclusions On condition that all other genetic or environmental factors remain stable, the existence and possible interaction between GJB2 rs3751385 C and T alleles in male psoriatic patients may be considered as protective gene component against late-onset psoriasis appearance, while presence of the T allele in female might block the histogenetic mechanisms of early-onset psoriasis lesions.

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Is late-onset psoriasis a distinct subtype of chronic plaque psoriasis?

Abstract: Linked Article: Theodorakopoulou et al. Br J Dermatol 2016; 175:1038–1044.

Cited by 3 publications

References 7 publications

Association of Psoriasis With Anxiety and Depression: A Case–Control Study in Chinese Patients

Association of Psoriasis With Anxiety and Depression: A Case–Control Study in Chinese Patients

Does Age Matter in Psoriatic Arthritis? A Narrative Review

Assessment of Gap Junction Protein Beta-2 rs3751385 Gene Polymorphism in Psoriasis Vulgaris

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