Early- and Late-Onset Breast Cancer Types Among Women in the United States and Japan

Matsuno, Rayna K.; Anderson, William F.; Yamamoto, Seiichiro; Tsukuma, Hideaki; Pfeiffer, Ruth M.; Kobayashi, Ken; Devesa, Susan S.; Levine, Paul H.

doi:10.1158/1055-9965.epi-07-0108

Cited by 60 publications

(51 citation statements)

References 33 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the incidence of invasive breast cancer in women is lower in Asian countries than in western countries, it has been rapidly increasing in parts of Asia, including Singapore, Korea, Japan, and Taiwan (1)(2)(3)(4). Similar to findings in Japan (3), our previous age-period-cohort analysis showed a significantly stronger birth cohort effect on the incidence trend of breast cancer in Taiwanese than in Caucasian Americans.…”

Section: Introductionsupporting

confidence: 74%

Molecular Subtypes of Breast Cancer Emerging in Young Women in Taiwan: Evidence for More Than Just Westernization as a Reason for the Disease in Asia

Lin¹,

Liau²,

Lu³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

108

View full text Add to dashboard Cite

Background: In the past two decades, the incidence of breast cancer in young Taiwanese females has been rapidly increasing, approaching the risk level of western countries. As a first step to investigate the possible etiology, we examined the molecular subtypes of female breast cancer in Taiwan.Methods: This study included 1,028 consecutive patients with breast cancer diagnosed in National Taiwan University Hospital between 2004 and 2006. Estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2, cytokeratin 5/6, and epidermal growth factor receptor expression and/or gene amplification were analyzed. Results: Younger (≤50 years) breast cancer patients had a higher prevalence of luminal A (67% versus 57%; P < 0.001) and a lower prevalence of basal-like subtype (9% versus 17%; P < 0.001) compared with older (>50

show abstract

Section: Introductionsupporting

confidence: 74%

Molecular Subtypes of Breast Cancer Emerging in Young Women in Taiwan: Evidence for More Than Just Westernization as a Reason for the Disease in Asia

Lin¹,

Liau²,

Lu³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

108

View full text Add to dashboard Cite

show abstract

“…The incidence of breast cancer in women has been rapidly increasing in Asia (Matsuno et al, 2007;Lin et al, 2009). Mammographic screening has a significant effect to decrease breast cancer mortality.…”

Section: Discussionmentioning

confidence: 99%

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

Wang¹,

Chen²,

Yin³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Purpose: Mammography has been confirmed as the only effective mode to improve the prognosis of patients with breast cancer in Western developed countries, but might not be a good choice in other areas of the world. One of the major challenges in China is to determine an optimal imaging modality for breast cancer screening. This study was designed to clarify the sensitivity of ultrasonography compared with that of mammography in rural China. Methods: We retrospectively studied the sensitivity of mammography and ultrasonography based on 306 breast cancer patients detected by the program of "screening for cervical cancer and breast cancer" performed in Chinese rural areas between January 2009 and December 2011, and analyzed the effects of age, breast density and volume on the sensitivity. Results: Stratified analysis showed that the sensitivity of breast ultrasonography was significantly higher than that of mammography in premenopausal patients (81.4% vs. 61.1%, p=0.02), in women ≤ 55 years of age (82.2% vs. 63.4%, p<0.01), in the high breast density group (American College of Radiology [ACR] levels 3-4) (85.9% vs. 60.6%, p<0.01) and in the small breast volume group (≤400 ml) (87.1% vs. 66.7%, p<0.01). Age had a significant effect on sensitivity of mammography (breast density and volume-adjusted odds ratio, 6.39; 95% confidence interval, 2.8-14.4 in age group > 55 compared to age group ≤ 45), but not that of ultrasonography. Neither breast density nor volume had significant effect on sensitivity of mammography or ultrasonography. Conclusions: Ultrasonography is more sensitive than mammography in detecting breast cancer in women under 55 year-old Chinese, especially in those with high-density and relatively small breasts.

show abstract

“…In our study, family history was considered positive if either a mother or sister had had breast cancer. Former smokers and former drinkers were defined as subjects who had quit smoking or drinking, respectively, at least 1 year previously.-2 Low drinker means ingesting <5 g ethanol/day.- 3 Moderate drinker means ingesting between 5 g ethanol/day and <15 g ethanol/day.- 4 Heavy drinker means ingesting 15 g ethanol/day.…”

Section: Assessment Of Environmental Factorsmentioning

confidence: 99%

FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: Results of a case control study in Japan

Kawase

Matsuo

Suzuki

et al. 2009

Intl Journal of Cancer

View full text Add to dashboard Cite

Recently, 2 genome-wide association studies demonstrated that single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2 (FGFR2) gene at intron 2 are significantly associated with the risk of female breast cancer. As the next step, it is necessary to evaluate the interaction between these SNPs and known risk factors of breast cancer because such an evaluation could elucidate mechanisms of carcinogenesis and lead to preventive advances. We conducted a case-control study of 456 newly and histologically diagnosed breast cancer cases and 912 age-and menopausal status-matched noncancer controls. The impact of 5 FGFR2 intronic SNPs on the risk of breast cancer and the interactions between these SNPs and various known risk factors of breast cancer were evaluated in both pre and postmenopausal women. We observed a statistically significant association between 4 SNPs and breast cancer risk and these 4 SNPs were in strong linkage disequilibrium in the Japanese population. rs2420946 was associated with a population-attributable risk of 17.7%. We found that FGFR2 polymorphisms interact with family history of breast cancer (interaction p 5 0.003) and reproductive risk factors, namely, age at menarche (interaction p 5 0.019) and parity (interaction p 5 0.026). Of note, a significant association between body mass index (BMI) 25 and FGFR2 polymorphism was observed among postmenopausal women (trend p 5 0.012), but not among premenopausal women. In contrast, BMI < 25 had no significant association with this polymorphism regardless of menopausal status. These findings suggest that FGFR2 intronic SNPs affect the reproductive hormone-related pathway and contribute to the development of female breast cancer in the Japanese population. ' UICCKey words: breast cancer; reproductive hormone; FGFR2 intronic polymorphisms Breast cancer ranks first among cancers affecting women worldwide. 1 The incidence rate of breast cancer in the Japanese population is generally lower than that in Caucasian populations and higher than that in other Asian populations. 2 In the Japanese population 3 and in other Asian populations, 4 the incidence of breast cancer increases rapidly until menopause, and then it reaches a plateau or decreases.Recently, 2 large genome-wide association studies demonstrated that intronic single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2 (FGFR2) gene are significantly associated with the risk of female breast cancer, 5,6 although 1 study was conducted in sporadic postmenopausal women and the other was conducted in women who had a strong family history of breast cancer in the first stage of the study. Subsequently, the association of FGFR2 polymorphisms with breast cancer was reported in Jewish and Arab Israeli populations, 7 Chinese population 8 and European-American but not African-American population. 9 Several other studies indicated that FGFR2 is associated with carcinogenesis of some types of cancer; that is, overexpression or missense mutation of FGFR2 occurs in breas...

show abstract

Early- and Late-Onset Breast Cancer Types Among Women in the United States and Japan

Cited by 60 publications

References 33 publications

Molecular Subtypes of Breast Cancer Emerging in Young Women in Taiwan: Evidence for More Than Just Westernization as a Reason for the Disease in Asia

Molecular Subtypes of Breast Cancer Emerging in Young Women in Taiwan: Evidence for More Than Just Westernization as a Reason for the Disease in Asia

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: Results of a case control study in Japan

Contact Info

Product

Resources

About