Molecular Subtypes of Breast Cancer Emerging in Young Women in Taiwan: Evidence for More Than Just Westernization as a Reason for the Disease in Asia

Lin, Ching-Hung; Liau, Jau–Yu; Lu, Yen‐Shen; Huang, Chiun‐Sheng; Lee, Wei-Chung Allen; Kuo, Kuan‐Ting; Shen, Ying‐Chun; Kuo, Sung‐Hsin; Lan, Chieh; Liu, Jacqueline Ming; Kuo, Wun-Hon; Chang, King‐Jen; Cheng, Ann‐Lii

doi:10.1158/1055-9965.epi-09-0096

Cited by 108 publications

(93 citation statements)

References 40 publications

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“…The incidence of breast cancer in women has been rapidly increasing in Asia (Matsuno et al, 2007;Lin et al, 2009). Mammographic screening has a significant effect to decrease breast cancer mortality.…”

Section: Discussionmentioning

confidence: 99%

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

Wang¹,

Chen²,

Yin³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Purpose: Mammography has been confirmed as the only effective mode to improve the prognosis of patients with breast cancer in Western developed countries, but might not be a good choice in other areas of the world. One of the major challenges in China is to determine an optimal imaging modality for breast cancer screening. This study was designed to clarify the sensitivity of ultrasonography compared with that of mammography in rural China. Methods: We retrospectively studied the sensitivity of mammography and ultrasonography based on 306 breast cancer patients detected by the program of "screening for cervical cancer and breast cancer" performed in Chinese rural areas between January 2009 and December 2011, and analyzed the effects of age, breast density and volume on the sensitivity. Results: Stratified analysis showed that the sensitivity of breast ultrasonography was significantly higher than that of mammography in premenopausal patients (81.4% vs. 61.1%, p=0.02), in women ≤ 55 years of age (82.2% vs. 63.4%, p<0.01), in the high breast density group (American College of Radiology [ACR] levels 3-4) (85.9% vs. 60.6%, p<0.01) and in the small breast volume group (≤400 ml) (87.1% vs. 66.7%, p<0.01). Age had a significant effect on sensitivity of mammography (breast density and volume-adjusted odds ratio, 6.39; 95% confidence interval, 2.8-14.4 in age group > 55 compared to age group ≤ 45), but not that of ultrasonography. Neither breast density nor volume had significant effect on sensitivity of mammography or ultrasonography. Conclusions: Ultrasonography is more sensitive than mammography in detecting breast cancer in women under 55 year-old Chinese, especially in those with high-density and relatively small breasts.

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Section: Discussionmentioning

confidence: 99%

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

Wang¹,

Chen²,

Yin³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…(7) 23 (9) 32 (5) 117 (8) 179 (7) 222 (7) 208 (8) 106 (6) 85 (7) 155 (7 (23) 53 (21) 130 (22) 331 (23) 600 (24) 740 (23) 622 (23) 420 (23) 280 (22) 446 (21) 4-9 1,715 (11) 26 (10) 59 (10) 147 (10) 274 (11) 311 (10) 292 (11) 222 (12) 160 (13) 224 (11) . 9 1,286 (8) 11 (4) 49 (8) 107 (8) 205 (8) 231 (7) 228 (9) 162 (9) 109 (9) 184 (9) (20) 42 (17) 105 (18) 279 (20) 504 (20) 574 (18) 537 (20) 415 (22) 284 (22) 458 ( (15) 27 (13) 74 (14) 164 (13) 356 (16) 506 (18) 339 (14) 217 (13) ...…”

Section: Clinicopathological Characteristics By Age Groupsunclassified

Distinct Clinicopathological Features and Prognosis of Emerging Young-Female Breast Cancer in an East Asian Country: A Nationwide Cancer Registry-Based Study

et al. 2014

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Background. A rapid surge of young-female breast cancer (YFBC) has been observed in Taiwan and other East Asian countries. We recently reported that these cases of YFBC, in contrast to their Western counterparts, are predominantly luminal A subtype.YFBC inAsiamayhavedistinctclinicopathologicalfeaturesandoutcomes. Methods. Data collected prospectively by participating hospitals were retrieved from the Taiwan Cancer Database. A total of 15,881 women with newly diagnosed stage I-III breast cancer in 2002-2006 were included. The age at diagnosis was categorized into nine 5-year groups (from ,30 years to $65 years). Clinicopathological variables and patient disease-free survival (DFS) were compared by age group. Results. The rates of stage I, estrogen receptor-positive (ER1), and progesterone receptor-positive breast cancer were higher

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“…ACS guidelines for breast cancer based on clear evidences indicate that screening reduces mortality (Smith et al, 2014). Recent years, the incidence of breast cancer has been rapidly increasing among women in China (Lin et al, 2009;Fan et al, 2009), especially among younger women (Yang et al, 2006). Breast cancer has been the second most common cause of incidence from cancer in Chinese women (Zhang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Mammographic Breast Density in a Group of Screening Chinese Women and Breast Cancer Patients

Liu¹,

Liu²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: A dense breast not only reduces the sensitivity of mammography but also is a moderate independent risk factor for breast cancer. The percentage of Western women with fat breast tissue is higher aged 40 years or older. To a certain extent, mammography as a first choice of screening imaging method for Western women of this group is reasonable. Hitherto, the frequency and age distribution of mammographic breast density patterns among Chinese women had not been characterized. The purpose of this study was to investigate the frequency and age distribution of mammographic breast density patterns among a group of Chinese screening women and breast cancer patients in order to provide useful information for age-specific guidelines for breast cancer screening in Chinese women. Methods: A retrospective review of a total of 3,394 screening women between August and December 2009 and 2,527 breast cancer patients between July 2011 and June 2012 was conducted. Descriptive analyses were used to examine the association between age and breast density. The significance of differences of breast density between the screening women and the breast cancer patients was examined using nonparametric tests. Results: There was a significant inverse relationship between age and breast density overall (r=-0.37, p< 0.01). Breast density of the breast cancer patients in the subgroups of 40-49 years old was greater compared with that of the screening women, the same in those aged 50-54 years and in those 55 years old or older, less than in the screening group. Conclusions: With regard to the Chinese women younger than 55 years old, the diagnostic efficiency of breast cancer screening imaging examinations may be potentially improved by combining screening mammography with ultrasound.

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Molecular Subtypes of Breast Cancer Emerging in Young Women in Taiwan: Evidence for More Than Just Westernization as a Reason for the Disease in Asia

Cited by 108 publications

References 40 publications

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

Distinct Clinicopathological Features and Prognosis of Emerging Young-Female Breast Cancer in an East Asian Country: A Nationwide Cancer Registry-Based Study

Analysis of Mammographic Breast Density in a Group of Screening Chinese Women and Breast Cancer Patients

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