Early and Late Efficacy on Wound Healing of Silver Nanoparticle Gel in Males after Circumcision

Abstract

We evaluate the early and late safety and efficacy of silver nanoparticle (AgNPs) in wound healing after circumcision. This multicenter prospective comparative non-randomized observational study compares wound dressing with AgNPs (group A) vs. gentamicin cream (group B). Follow-up included objective evaluation at 10 and 30 days by the Southampton Scoring System (SSS) and Stony Brook Scar Evaluation Scale (SBSES). We enrolled 392 males: 194 in group A, and 198 in group B. At 10 days follow-up, in group A, the SSS scale was grade 1 in 49.5% and grade 2 in the remaining; meanwhile, in group B, grade 1 was in 58%, grade 2 in 34.3%, and grade 4 in 7.6%. At 30 days follow-up, grade 1 healing was 97.4% and 98.4% in group A and B, respectively. At 10 days follow-up, the mean SBSES score was 3.58 and 3.69 in group A and B, respectively; while at 30 days follow-up, 4.81 and 4.76 in group A and B, respectively. Only in group B did 7.6% of males have antibiotic therapy due to pus discharge. No patients needed surgical wound revision. AgNPs led to a late but safer healing, they were non-inferior to the antibiotic cream wound dressing efficacy, and they avoided pus discharge and the need for oral antibiotics due to their polymer material.

Biosynthesis of Silver Nanoparticles Using Salvia pratensis L. Aerial Part and Root Extracts: Bioactivity, Biocompatibility, and Catalytic Potential

“…The most frequently synthesized nanotechnology products are silver nanoparticles (AgNPs), which have special qualities, including high chemical stability, antibacterial, antiviral, antioxidant, anti-inflammatory, anticancer activities, and conductivity. Their usage as an alternative to antibiotics, particularly in wound healing, has been extensively researched [ 8 ]. Moreover, they also exhibit minimal cytotoxicity and immunological reaction and are inexpensive.…”

Effect of Plant Extracts on the Characteristics of Silver Nanoparticles for Topical Application

“…Silver nanoparticles (AgNPs) are among the most interesting nanotechnology products as they possess unique properties such as conductivity and good chemical stability, as well as antimicrobial, antiviral, anti-inflammatory, antioxidant, and anticancer activity. Especially in wound healing, their use as antibiotics’ substitution is widely studied [ 3 ]. All the above has triggered the broad use of the AgNPs in pharmaceutical and cosmetic products, the food industry, etc.…”

Process Optimization for Green Synthesis of Silver Nanoparticles Using Indonesian Medicinal Plant Extracts

“…Silver nanoparticles (AgNPs) are interesting metal nanoparticles, whose unique physical and chemical properties are responsible for their antimicrobial applications in pharmaceutical and clinical areas, cosmetics, and dentistry. Wound dressings with AgNPs also have the potential to be used as an alternative for topical antibiotics, which have been proven to be effective and safe [6,7]. AgNPs naturally interact with bacterial membranes and interfere with their integrity, further binding to sulfur, oxygen, and nitrogen of essential biological molecules, while inhibiting bacterial growth [8].…”