Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients

Curley, Steven A.; Marra, Paolo; Beaty, Karen A.; Ellis, Lee M.; Vauthey, Jean Nicolas; Abdalla, Eddie K.; Scaife, Courtney L.; Raut, Chan; Wolff, Robert; Choi, Haesun; Loyer, Evelyne M.; Vallone, Paolo; Fiore, Francesco; Scordino, Fabrizio; Rosa, Vincenzo De; Orlando, Raffaele; Pignata, Sandro; Daniele, Bruno; Izzo, Francesco

doi:10.1097/01.sla.0000118373.31781.f2

Cited by 342 publications

(267 citation statements)

References 35 publications

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“…This boundary condition is similar to previously published experimental measurements from rat livers [19]. Far enough into the non-ablated normal liver (nl), the drug concentration was assumed negligible because of the elimination process: (4) For condition (A) with normal tissue, the drug concentration and flux were assumed continuous at the boundary between the ablated normal liver (al) and non-ablated liver (nl):…”

Section: Drug Transport Modelmentioning

confidence: 78%

“…While its ease of use and minimally invasive nature have allowed this treatment modality to reach the forefront of ablative cancer treatments, tumor recurrence has been significant, particularly when RF ablation is applied percutaneously [2,4,10]. To address this limitation, biodegradable polymer implants were designed to release chemotherapeutic drugs into tumors after RF ablation.…”

Section: Introductionmentioning

confidence: 99%

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Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants

Weinberg

Patel

et al. 2008

Med Biol Eng Comput

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Radiofrequency ablation has emerged as a minimally invasive option for liver cancer treatment, but local tumor recurrence is common. To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of this method has been the extent of drug penetration into the tumor (< 5 mm), especially in the peripheral tumor rim where thermal ablation is less effective. To provide drug concentration above the therapeutic level as needed throughout a large tumor, implant strategies with multiple millirods were devised using a computational model. This dynamic, 3-D mass balance model of drug distribution in tissue was used to simulate the consequences of various numbers of implants in different locations. Experimental testing of model predictions was performed in a rabbit VX2 carcinoma model. This study demonstrates the value of multiple implants to provide therapeutic drug levels in large ablated tumors.

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Section: Drug Transport Modelmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants

Weinberg

Patel

et al. 2008

Med Biol Eng Comput

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“…Vogl et al reported three deaths and infrequent severe adverse events whereas the majority of patients only had minor complications in an analysis of a large series of 2 132 LITT-procedures in patients with primary or secondary liver tumors [23]. In a study on RFA of 608 patients by Curley et al [24] there were three treatment related deaths (0.5%) and complications in 58 patients (9.5%). Severe events after these minimal invasive procedures generally includes abscess of the liver or peritoneum, bile duct injury, pleural effusion, segmental liver infarction or haemorrhage or haematoma that often requires surgical intervention or medical conditions such as cardiac or kidney failure, pneumonia or other infection.…”

Section: Discussionmentioning

confidence: 99%

Phase II study on stereotactic body radiotherapy of colorectal metastases

et al. 2006

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“…The complication rate is 5%-10%, and the mortality rate is low, with a reduction in complications with increasing experience with this technique [72]. The use of RFA in metastases of neuroendocrine tumors has been reported in small series.…”

Section: Radiofrequency Ablationmentioning

confidence: 99%

Metastatic Carcinoid Tumors: A Clinical Review

2005

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Carcinoid tumors are neuroendocrine tumors derived from enterochromaffin cells, which are widely distributed in the body. They can originate from any location in the body, but they are traditionally described as originating from the foregut, midgut, and hindgut. Although the overall incidence of carcinoid tumors appears to have increased in the past decades, the prognosis for patients with metastatic carcinoid tumors has improved during the last decade. Due to longer survival times, complications, such as carcinoid heart disease, and new metastatic patterns, like skin and bone metastases, may become more important features of carcinoid disease. Therapy focused on these complications should be part of the management. Combining new diagnostic and treatment modalities in metastatic carcinoid patients may result in better quality of life and longer survival times. The increasing number of therapeutic options and diagnostic procedures requires a multidisciplinary approach, with decisions made in multidisciplinary meetings focused on "tailor-made" therapy based on patients' specific conditions. Because carcinoid tumors are uncommon, effort should be made to treat these patients in specialized centers and for these centers to join together in multicenter studies. The Oncologist 2005;10:123-131The Oncologist 2005;10:123-131 www.TheOncologist.com

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Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients

Abstract: Hepatic tumor RFA can be performed with low mortality and morbidity rates. Though relatively rare, late complications can develop and physicians performing hepatic RFA must be cognizant of these delayed treatment-related problems.

Cited by 342 publications

References 35 publications

Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants

Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants

Phase II study on stereotactic body radiotherapy of colorectal metastases

Metastatic Carcinoid Tumors: A Clinical Review

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