Early alterations of blood pressure in normotensive and normoalbuminuric Type 1 diabetic patients

Cohen, C.; Filho, Francisco Manes Albanesi; Gonçalves, Maria Eduarda; Gomes, Marı́lia B.

doi:10.1016/s0168-8227(01)00247-9

Cited by 24 publications

(20 citation statements)

References 21 publications

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“…Nielsen et al 63 , found 23% white coat prevalence in normoalbuminuric individuals, 8% in microalbuminuric individuals, and 9% in macroalbuminuric patients. Thus, normoalbuminuric patients did not differ from the prevalence expected for essential hypertension patients (20%-30%) 37 .…”

mentioning

confidence: 62%

“…Patients with Type 1 DM have higher 24-hour BP means, both systolic and diastolic, in comparison with controls who do not have DM 36,37 .…”

Section: Mean Pressure Values and Diabetes Mellitusmentioning

confidence: 85%

“…An elevated prevalence non-dipping pattern of BP fall absence was observed in patients with Type 1 DM 36,37 , reaching up to 78% of patients, as compared to 39% of the controls who did not have DM 37 . These changes in ABPM measurements correlate with the presence of cardiovascular autonomic neuropathy (CAN) [46][47][48] .…”

Section: Absence Of Nocturnal Dipping Pattern Of Blood Pressure Fall mentioning

confidence: 87%

“…The greatest prevalence of absence of nocturnal BP fall in the studies carried out in Type 1 DM patients compared to those with Type 2 DM (78% versus 30%) 34,37 may be related to greater DM decompensation in the first group. Hyperglycemia modifies circulating plasma volume, and can interfere in renal hemodynamics and blood flow distribution, changing the normal nocturnal BP fall.…”

Section: Masked Hypertension (%)mentioning

confidence: 89%

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Monitorização ambulatorial da pressão arterial e diabete melito tipo 2

Leitão¹,

Canani²,

Silveiro³

et al. 2007

Arq. Bras. Cardiol.

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SummaryHypertension is one of the main risk factors for the onset and progression of chronic complications in type 2 diabetes mellitus (DM).Ambulatory blood pressure (BP) monitoring (ABPM) provides a better correlation with target organ lesions than BP obtained in the office. Furthermore, it allows the evaluation of distinct BP parameters such as the 24-h, daytime and nighttime systolic and diastolic BP means, BP loads and the absence of nocturnal drop of BP, as well as the identification of white-coat and masked hypertension.DM patients have higher daytime and nighttime BP means than non-DM patients. In addition, one third of normotensive type 2 DM patients have masked hypertension, which is associated with an increase in albuminuria and in left ventricle wall thickness. On the other hand, the prevalence and effect of white-coat hypertension in type 2 DM patients have not yet been properly evaluated. The absence of nocturnal drop of BP does not add information to the 24 h, daytime or nighttime BP measurements, but the nighttime BP means seem to be relevant in DM retinopathy.In conclusion, BP determination by ABPM allows better patient risk stratification for the development of DM chronic complications and is an essential instrument for effective BP control in these patients. Arterial pressure and diabetes mellitusType 2 diabetes mellitus (DM) is associated with the development of chronic microvascular and macrovascular complications with high rates of morbidity and mortality 1,2 . The classic and most analyzed risk factors for the development and progression of chronic DM complications are DM duration, hyperglycemia, arterial hypertension (AH), dyslipidemia, and smoking, besides genetic factors [3][4][5][6][7][8] . The treatment of hyperglycemia and SAH results in primary prevention and reduction of the progression of diabetic retinopathy (DR) and diabetic nephropathy (DN) 9,10

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mentioning

confidence: 62%

“…Patients with Type 1 DM have higher 24-hour BP means, both systolic and diastolic, in comparison with controls who do not have DM 36,37 .…”

Section: Mean Pressure Values and Diabetes Mellitusmentioning

confidence: 85%

Section: Absence Of Nocturnal Dipping Pattern Of Blood Pressure Fall mentioning

confidence: 87%

Section: Masked Hypertension (%)mentioning

confidence: 89%

See 2 more Smart Citations

Monitorização ambulatorial da pressão arterial e diabete melito tipo 2

Leitão¹,

Canani²,

Silveiro³

et al. 2007

Arq. Bras. Cardiol.

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“…However, previous reports have highlighted a high percentage of non-dippers already among normoalbuminuric populations with type 1 diabetes [45], wide overlaps between normoalbuminuric and microalbuminuric patients [8,16] as well as lack of associations between the nocturnal dipping and microalbuminuria after adjusting for potential confounders [8]. Based on these data and those from our study, the 'non-dipping' phenomenon does not appear to be predictive of risk of microalbuminuria, but it cannot be excluded that it may still be an important determinant of the rate of progression from microalbuminuria to overt diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 87%

Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes

et al. 2009

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Aims/hypothesis The relationship between BP and microalbuminuria in young people with type 1 diabetes is not completely clear. As microalbuminuria is preceded by a gradual rise in albumin excretion within the normal range, we hypothesised that ambulatory BP (ABP) may be closely related to albumin excretion and progression to microalbuminuria. Results All ABPM variables were significantly related to baseline log 10 ACR (p<0.001). After the ABPM evaluation, 287 patients were followed for a median of 2.2 (1.0-5.5) years. ABP at baseline was independently related to mean ACR during follow-up. Nineteen initially normoalbuminuric patients developed microalbuminuria after 2.0 (0.2-4.0) years and their baseline daytime DBP was higher than in normoalbuminuric patients (p<0.001). After adjusting for baseline ACR and HbA 1c , there was an 11% increased risk of microalbuminuria for each 1 mmHg increase in daytime DBP. Forty-eight per cent of patients were non-dippers for SBP and 60% for DBP; however, ACR was not different between dippers and non-dippers and there were no differences in the nocturnal fall in BP between normoalbuminuric and future microalbuminuric patients. Conclusions/interpretation In this cohort of young people with type 1 diabetes, ABP was significantly related to ACR, and daytime DBP was independently associated with progression to microalbuminuria. Increasing albumin excretion, even in the normal range, may be associated with parallel rises in BP. Methods

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Current Awareness

2001

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Prediction; 7 Prevention; 8 Intervention: a) General; b) Pharmacology; 9 Pathology: a) General; b) Cardiovascular; c) Neurological; d) Renal; 10 Endocrinology & Metabolism; 11 Nutrition; 12 Animal Studies; 13 Techniques. Within each section, articles are listed in alphabetical order with respect to author (12 Weeks journals ‐ Search completed at 24th Oct 2001)

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Early alterations of blood pressure in normotensive and normoalbuminuric Type 1 diabetic patients

Cited by 24 publications

References 21 publications

Monitorização ambulatorial da pressão arterial e diabete melito tipo 2

Monitorização ambulatorial da pressão arterial e diabete melito tipo 2

Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes

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