Earlobe Creases and Coronary Atherosclerosis

Cumberland, Gary D.; Riddick, LeRoy; Vinson, Richard P.

doi:10.1097/00000433-198703000-00003

Cited by 22 publications

(24 citation statements)

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“…In the study by Shoenfield et al, 21 the prevalence of ELC was 77% in patients with myocardial infarction and 40% in controls, regardless of age. In the forensic autopsy study by Cumberland et al, 15 ELC was found in only 24% of 777 consecutive autopsies. However, 64% of the subjects had died of unnatural causes, and the mean age was 34.8 years, which is much lower than in the present study, and there were no details regarding age distribution.…”

Section: Discussionmentioning

confidence: 91%

“…7,8,18,25 In one of the autopsy studies, Lichstein et al 3 used a 2-dimensional graded scoring system to assess the degree of coronary stenosis similar to what was done in the present study. In the study by Cumberland et al, 15 no details were reported how examination of the coronary arteries was done, and no criteria were given for the grading of atherosclerosis. Lichstein et al 2 found a prevalence for ELC of 47% (n ϭ 531) in patients with CAD and 30% in a control group (n ϭ 305).…”

Section: Discussionmentioning

confidence: 99%

“…10,11 So far, only a few autopsy studies on larger populations have been done. 3,[12][13][14][15] In a forensic postmortem study comprising 777 cases, Cumberland et al 15 found a positive correlation between coronary artery stenosis and ELC.…”

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confidence: 99%

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The Earlobe Crease, Coronary Artery Disease, and Sudden Cardiac Death

Edston¹

2006

The American Journal of Forensic Medicine and Pathology

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The majority of previous studies have demonstrated a correlation between diagonal earlobe creases (ELC) and coronary artery disease (CAD). In this study of 520 forensic autopsy cases, the earlobes were studied and photographed before autopsy, and the existence of a diagonal ELC was noted in 55%. The cause of death, the degree of coronary atherosclerosis, aortosclerosis, and cerebrosclerosis, as well as heart, kidney, and spleen weights, were noted in each case. The body mass index (BMI), thickness of abdominal fat, baldness, and excessive hair in the meatus externa of the external ears were also assessed. Nonparametric methods were used in the statistical calculations. It was found that ELC was strongly correlated with CAD in both men and women (P < 0.0001) but with sudden cardiac death (SCD) only in men (P < 0.04). The sensitivity of the ELC sign was 75% and the positive predictive value (ppv) was 68%. In individuals below 40 years, the ppv was as high as 80%. Using multiple logistic regression analysis, ELC was found to be the strongest independent risk factor for CAD and SCD apart from age and BMI (both genders), as well as baldness and hair in the meatus externa (in males). It is concluded that in a patient population similar to that in the present study the ELC sign could be especially useful in screening for premature CAD in younger individuals.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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The Earlobe Crease, Coronary Artery Disease, and Sudden Cardiac Death

Edston¹

2006

The American Journal of Forensic Medicine and Pathology

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“…However, genetic, environmental, and phenotypic variances seen in practice are often heterogeneous (Brotherstone and Hill, 1986). The bias caused by ignoring the heterogeneity of variance is severe, especially in the selection of dams of future sons, because progeny of a dam tend to make records in the same herd (Cumberland et al, 1987). Several procedures for accounting for heterogeneous variances have been presented (Gianola et al, 1992;Meuwissen and Van der Werf, 1993).…”

Section: Expanding the Mixed Modelmentioning

confidence: 99%

Accomplishments and new challenges in dairy genetic evaluations

Maltecca

Parker

Cassandro

2010

Italian Journal of Animal Science

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This review presents the evolution of dairy genetic methods to estimate breeding values. For centuries, human action has shaped animal populations by choosing progenitors of the next generation. Since the twentieth century, applied concepts were integrated into a new discipline, quantitative genetics. The past quarter-century in genetic evaluation of dairy cattle has been marked by evolution in methodology and computer capacity, expansion in the array of evaluated traits, and globalization. Selection index was replaced by mixed model procedures and animal models replaced sire and sire-maternal grandsire models. Recently, application of Bayesian theory to breeding values prediction and variance components estimation has become standard. Individual test-day observations have been used more effectively in the estimation of lactation yield as direct input to evaluation models. Computer speed and storage are less limiting in choosing procedures. National evaluations combined internationally provide evaluations for bulls from all participating countries on each of the national scales, facilitating choices from among many more bulls. Selection within countries has increased inbreeding and the use of similar genetics across countries reduces the previously available genetic diversity. Finally, considerable progress in genomics has created a new tool, genomic selection. The collection and analysis of several types of phenotypic data to evaluate genetic merit will continue to be the most important tool for genetic progress in the foreseeable future. Information will increasingly be obtained from smaller reference populations and the extrapolation from these data will require careful validation.

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“…Benzer bir postmortem çal›flmada Kirkham ve arkadafllar› (18), kardiyovasküler sebepli ölümler ile DKLÇ aras›nda iliflki oldu¤u sonucuna varm›fllard›r. Çal›flmam›z›n bulgular›, vakalara uygulanan anjiografiler sonucunda RIA, RC ve ACD'de saptanan daralma yüzdeleri artt›kça DKLÇ görülme s›kl›¤›n›n artt›¤›n› göstermekte olup DKLÇ ve koroner arter hastal›¤› aras›nda anlaml› iliflkiler bildiren * Sat›r yüzdesi ** Sütun yüzdesi daha önceki çal›flmalar›n bulgular› ile uyumludur (2,3,4,8,9,13,14,20,(24)(25)(26)(27)(28). Baz› araflt›r›c›lar bu iliflkiyi yalanlamakta ve yafl›n, ço¤unlukla yafll› kiflilerde bulunan DKLÇ'nin ortaya ç›k›fl›n› etkileyebilece¤i üzerinde durmaktad›rlar (5,10,16,17,(29)(30)(31).…”

Section: Tartifimaunclassified

Ölüm Nedeninin Tespitinde Yardımcı Bir Bulgu Diagonal Kulak Lobu Çizgisi

Demirel¹,

Bahçecioğlu²,

Akar³

et al. 2005

Bull Leg Med

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Demirel B, Bahçelio¤lu M, Akar T, fienol E. Ölüm nedeninin tespitinde yard›mc› bir bulgu: Diagonal kulak lobu çizgisi.Adli T›p Bülteni, 2005;10(2):50-55.Koroner arter hastal›klar›, do¤al sebeplerle meydana gelen ölüm nedenlerinin bafl›nda gelmektedir. Bu hastal›klar›n yük-sek insidans ve mortalite oranlar›, bilinen risk faktörlerinden çok, olas› risk faktörlerinin araflt›r›lmas›n› gerekli k›lm›flt›r. Bir fizik muayene bulgusu olan diagonal kulak lobu çizgisi (DKLÇ), 1973 y›l›nda tan›mlanm›flt›r. Çal›flmam›zda, DKLÇ'nin, ölü muayenesi yapan hekim için ölüm nedeninin tespitinde yard›mc› bir bulgu olup olamayaca¤›n›n saptanmas› amaçlanm›flt›r.Çal›flmam›z›n bulgular›, vakalara uygulanan anjiografiler sonucunda; a. coronaria sinistra?n›n dallar› olan ramus interventricularis anterior (RIA) ve ramus circumflexus (RC) ile a. coronaria dextra'da (ACD) saptanan daralma yüzdeleri artt›kça DKLÇ görülme s›kl›¤›n›n da artt›¤›n› göstermektedir. Bu durum DKLÇ ve koroner arter hastal›klar› aras›nda anlaml› iliflkiler bildiren daha önceki çal›flmalar›n bulgular› ile uyumludur.Özellikle öyküye ulaflma olana¤› bulunmayan ve herhangi bir travmatik bulgu saptanmayan vakalarda DKLÇ'nin, ölü-mün koroner arter hastal›¤›ndan meydana geldi¤i yönünde destekleyici bir bulgu olarak muayeneyi yapan hekimin dikkatini çekmesi gereken bir iflaret oldu¤unu düflünmekteyiz.Anahtar kelimeler: Diagonal kulak lobu çizgisi, koroner arter hastal›¤›, ölü muayenesi.Coronary artery disease is a major cause of natural death. The high incidence and mortality of these diseases arised a need to investigate possible risk factors beyond well known. Diagonal ear lobe crease (DEC), was the physical sign, described in 1973. We investigated the possibility of DEC as a helpful predictive sign in the postmortem examination of forensic sudden death cases.The angiographic results revealed that whenever the percentages of the stenosis in left descending coronary artery, circumflex artery and right coronary artery increased, the incidence of the DEC did so accordingly. These results were correlated with the previous studies reporting significant correlation between coronary artery disease and the DEC.Particularly, in the absence of supportive medical history and without a physical sign of trauma, the presence of DEC could well be a supportive sign for the physician to consider the coronary artery disease as a cause of death.

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Earlobe Creases and Coronary Atherosclerosis

Cited by 22 publications

References 0 publications

The Earlobe Crease, Coronary Artery Disease, and Sudden Cardiac Death

The Earlobe Crease, Coronary Artery Disease, and Sudden Cardiac Death

Accomplishments and new challenges in dairy genetic evaluations

Ölüm Nedeninin Tespitinde Yardımcı Bir Bulgu Diagonal Kulak Lobu Çizgisi

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