Ear, nose and throat manifestations in pemphigus vulgaris

España, A.; Fernández, Secundino; Olmo, Julio Del; Marquina, Miren; Pretel, Maider; Ruba, D; Sánchez-Ibarrola, A

doi:10.1111/j.1365-2133.2007.07783.x

Cited by 35 publications

(86 citation statements)

References 12 publications

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“…1 The majority of these authors' patients (67 per cent) had the mucocutaneous form of pemphigus vulgaris; similarly, 72.5 per cent of our study patients had the mucocutaneous form.…”

Section: Discussionsupporting

confidence: 65%

“…1 Two clinical subtypes of pemphigus vulgaris have been defined. The mucosal form of pemphigus vulgaris is characterised by a predominant anti-desmoglein 3 autoimmune response.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, the mucocutaneous form of pemphigus vulgaris shows a combined antidesmoglein 3 and anti-desmoglein 1 autoantibody response. 1 Laryngeal lesions due to pemphigus vulgaris are rarely reported, and the majority of such reports describe only the presence of such lesions, not their endoscopic location. [1][2][3][4][5][6] It is important to note that pemphigus vulgaris is a very rare disease with an estimated incidence of 0.7 patients per 100 000.…”

Section: Introductionmentioning

confidence: 99%

“…11 The most comprehensive study to date of laryngeal pemphigus vulgaris is a 2007 paper by España et al describing laryngeal involvement in 16 patients undergoing ENT endoscopic examination. 1 However, there is currently no uniform classification of laryngeal involvement in pemphigus vulgaris, particularly with regard to lesion characteristics and locations within the supraglottis and glottis.…”

Section: Introductionmentioning

confidence: 99%

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Laryngeal involvement in pemphigus vulgaris: a proposed classification

et al. 2012

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Objective: (1) To investigate the incidence of laryngeal involvement in a large series of patients with pemphigus vulgaris, using endoscopic examination, (2) to describe the lesions, and (3) to establish a classification of laryngeal involvement in pemphigus vulgaris based on the location of the lesions.Study design: Prospective study.Methods: A total of 40 sequentially treated pemphigus vulgaris patients, diagnosed using clinical, histological and immunofluorescence criteria, were evaluated for laryngeal manifestations using endoscopic examination. The results were used to establish a graded classification of laryngeal involvement according to the location of the lesions.Results: Active laryngeal lesions (ulcers or blisters) were found in 16 patients (40 per cent). Of these, 37.5 per cent were classified as grade I, 20 per cent as grade II, 20 per cent as grade III and 17.5 per cent as grade IV.Conclusion: Laryngeal involvement is common in pemphigus vulgaris and must be considered at the point of diagnosis. Grade I lesions are the most frequent.

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“…1 The majority of these authors' patients (67 per cent) had the mucocutaneous form of pemphigus vulgaris; similarly, 72.5 per cent of our study patients had the mucocutaneous form.…”

Section: Discussionsupporting

confidence: 65%

“…1 Two clinical subtypes of pemphigus vulgaris have been defined. The mucosal form of pemphigus vulgaris is characterised by a predominant anti-desmoglein 3 autoimmune response.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Laryngeal involvement in pemphigus vulgaris: a proposed classification

et al. 2012

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“…It is characterized by the development of intraepithelial blisters secondary to IgG antibody synthesis against desmoglein (desmosomal glycoprotein) present in keratinocytes. 2 Endemic pemphigus foliaceus has familial cases and has no involvement of the oral and upper airway mucosa, whereas pemphigus vulgaris involves upper airway mucosa. 3 Two clinical subtypes of pemphigus vulgaris have been reported.…”

Section: Introductionmentioning

confidence: 99%

Is laryngeal involvement in pemphigus vulgaris rare? A review

Bansal

2015

Int J Res Dermatol

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<p>The lesions of pemphigus in the larynx have been reported as case reports. However, the frequency with which it occurs is not known. The purpose of this study was to investigate the incidence of laryngeal involvement in pemphigus vulgaris and to examine the laryngeal lesions and the treatment in detail. The databases searched were PubMed, EMBASE, Cochrane Library and Google scholar. The involvement of larynx in patients with pemphigus vulgaris is common. The most common parts involved are epiglottis and arytenoids. This study indicates that laryngeal symptoms are common in pemphigus vulgaris. Laryngeal findings must be considered at the beginning of diagnosis for the better management and to prevent life threatening complications.</p>

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