Ear involvement in systemic lupus erythematosus patients: a comparative study

Jiménez-Alonson, J.; Gutiérrez-Cabello, Francisco; Castillo, J. L.; Sabio, José Mario; Hidalgo-Tenorio, Carmen; Léon, L.

doi:10.1258/002221502760238127

Cited by 4 publications

(5 citation statements)

References 4 publications

(5 reference statements)

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“…Furthermore, half of the mice do not develop hearing loss at all, in spite of severe systemic disease (Table 1). This parallels the commonly reported clinical observation that only 15-60% of lupus patients have a measurable hearing loss (Jimenez-Alonson et al, 2002;Kastanioudakis et al, 2002;Sperling et al, 1998;Andonopoulos et al, 1995). Thus, the hearing levels of C3.MRL-Fas lpr mice are within reported norms for both people and mice with autoimmune disease.…”

Section: Discussionsupporting

confidence: 88%

Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice

et al. 2007

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Section: Discussionsupporting

confidence: 88%

Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice

et al. 2007

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“…Many studies found no association between the use of these drugs and HL in patients with SLE. 6,8,10,21 However, medication use remains as a potential confounder in the present study.…”

Section: Discussionmentioning

confidence: 76%

“…Screening by title and abstract excluded 573 articles. A full-text review of remaining studies further eliminated 18 articles, leaving a total of 17 articles 6–8,10,11,17–28 for inclusion in the final analysis. A diagram outlining the summary of the search process is shown in Supplementary Figure S1.…”

Section: Resultsmentioning

confidence: 99%

“…Only studies that provided sufficient data on audiological outcomes of interest were included in the meta-analysis. Of the 17 studies, 14 studies 6–8,10,17,19–21,23–28 were used to analyze the risk of HL in patients with SLE, nine studies 6,8,11,17,19,22,24,27,28 were used to pool frequency-specific air- and bone-conduction PTT data, and two studies 8,24 were used to compare the serological and clinical profiles of patients with SLE with and without HL.…”

Section: Resultsmentioning

confidence: 99%

“…followed subjects in both groups with audiological evaluations for 10 years, no evidence of progressive HL was observed in the case cohort. 19 Six of the remaining studies 6,10,17,21,24,27 observed middle- and high-frequency SNHL among their patient cohort with SLE. As suggested by Andonopoulos et al.…”

Section: Discussionmentioning

confidence: 99%

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Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Yuen

Fried

Nguyen

et al. 2021

Lupus

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Objective To determine the prevalence of hearing loss (HL) in patients with systemic lupus erythematosus (SLE), describe frequency-specific hearing threshold changes in this patient population as compared to age-matched control, and compare the clinical and serological profiles of patients with SLE with and without HL. Methods A systematic review querying four databases (PubMed, Web of Science, Scopus, and Cochrane) was performed. Meta-analysis of available data was performed to determine the overall prevalence and odds ratio (OR) of HL, and compare mean differences in frequency-specific hearing thresholds between patients with SLE and control. Additionally, meta-analysis of proportions allowed for comparison of disease features present in patients with SLE with and without sensorineural HL. Results This review included 17 studies reporting on 1326 patients (635 with SLE and 691 control). The pooled prevalence of HL in patients with SLE was 27%. In comparison to control, patients with SLE had a significantly higher odds of HL (OR 14.6, 95% CI: 8.5 to 25.0). Mean air-conduction hearing thresholds in patients with SLE were significantly elevated relative to control at 125 and 250 Hz. Mean bone-conduction hearing thresholds were significantly elevated in patients with SLE across all measured frequencies except at 3000 and 6000 Hz compared to control. Disease features did not significantly differ between patients with SLE with and without HL. Conclusion Compared to age-matched control, patients with SLE have increased odds of HL, which primarily manifests at low frequencies. Therefore, this patient population requires greater audiologic attention.

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Estudio de comorbilidad de la hipoacusia neurosensorial y otras enfermedades de patogenia autoinmune. Utilidad de las pruebas de laboratorio

Callejo¹,

Vernetta²,

Sabio³

et al. 2006

Acta Otorrinolaringológica Española

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Ear involvement in systemic lupus erythematosus patients: a comparative study

Cited by 4 publications

References 4 publications

Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice

Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice

Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Estudio de comorbilidad de la hipoacusia neurosensorial y otras enfermedades de patogenia autoinmune. Utilidad de las pruebas de laboratorio

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