Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Yuen, Erick; Fried, Jacob; Nguyen, Shaun A.; Rizk, Habib G.; Ward, Celine; Meyer, Ted A.

doi:10.1177/0961203321997919

Cited by 6 publications

(4 citation statements)

References 28 publications

(79 reference statements)

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“… 7 Interestingly, hearing loss occurs significantly more often in patients with SLE as compared with healthy individuals. 14 Here we show that the truncated isoform of GPSM2 containing the GoLoco motif region promotes CD4 + T-cell migration and is overexpressed in patients with SLE. This mechanism may explain the enhanced migratory capacity of CD4 + T cells in SLE.…”

Section: Discussionmentioning

confidence: 64%

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4⁺T-cell migration in SLE

et al. 2022

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ObjectiveSLE is an autoimmune disease with a complex pathogenesis. T-cell infiltration into organs contributes to inflammation and organ damage in SLE. Recently, G-protein signalling modulator 2 (GPSM2) has been shown to be implicated in T-cell migration.MethodsWe analysed the expression levels of GPSM2 and of a truncated isoform of GPSM2 containing the GoLoco motif region in CD4+ T cells from patients with SLE and from healthy individuals by western blot. In a next step, we studied the role of the truncated GPSM2 isoform using a CD4+ T-cell migration assay.ResultsOur experiments revealed comparable levels of GPSM2 in CD4+ T cells from patients with SLE and healthy controls. In contrast, the truncated 35 kDa isoform of GPSM2 was significantly more highly expressed in CD4+ T cells from patients with SLE as compared with healthy subjects. Antibody-mediated blockade of the 35 kDa GPSM2 isoform reduced the in vitro capacity of CD4+ T cells to migrate towards the chemokine CCL20.ConclusionsA truncated GPSM2 isoform containing the GoLoco motif region is upregulated in CD4+ T cells from patients with SLE and promotes CD4+ T-cell migration. Targeting this isoform with specific antibodies might be a promising approach to reduce CD4+ T-cell infiltration into inflamed tissues and to prevent organ damage in SLE.

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Section: Discussionmentioning

confidence: 64%

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4⁺T-cell migration in SLE

et al. 2022

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“…This figure is slightly higher than what was reported in a 2022 study by Sarmar Tharwat, which found a 24% prevalence of hearing loss in SLE patients (31). Furthermore, Erick Yuen's 2021 research also highlighted a comparable prevalence rate, with 27% of SLE patients reporting hearing impairment (13). These comparative studies collectively suggest that hearing impairment is a noteworthy concern in the SLE patient population.…”

Section: Discussionmentioning

confidence: 74%

“…Normal hearing thresholds range from 25 to 40 decibels (dB). The medical community often uses terms like "hearing impairment" and "hearing loss" interchangeably, particularly when audiometry indicates hearing below normal thresholds (12,13). Hearing impairments are generally classified into two types: sensorineural hearing loss (SNHL) and conductive hearing loss (CHL).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hearing Impairment Among Systemic Lupus Erythematosus Patients

Cheema,

Khan,

Badar

et al. 2023

JHRR

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Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with varied manifestations, including potential auditory complications. Previous studies have indicated varying prevalence rates of hearing impairment among SLE patients, necessitating further research to understand the extent and nature of these auditory issues. Objective: The primary aim of this study was to assess the prevalence and characteristics of hearing impairment in SLE patients, with a focus on identifying the types and degrees of hearing loss and associated symptoms like tinnitus and vertigo. Methods: This observational, cross-sectional study involved 38 SLE patients from Sir Ganga Ram Hospital, Lahore, and DHQ Hospital, Bhimber, Kashmir. Participants underwent pure tone audiometry (PTA) to assess hearing impairment. Data were analyzed using SPSS version 24.0, with a focus on qualitative variables like gender, education, and socio-economic status. Patients with SLE-associated co-morbid factors affecting hearing were excluded. Results: The study found a 29% prevalence of hearing impairment among SLE patients, with sensorineural hearing loss being the most common type (21.1%). Conductive hearing loss and mixed hearing loss were observed in 2.6% and 5.3% of patients, respectively. The majority of hearing impairments were of mild to moderate degree. Additionally, 23.7% of patients reported tinnitus, and 18.45% experienced vertigo. Conclusion: The study concludes that hearing impairment, particularly sensorineural hearing loss of a mild to moderate degree, is a significant concern in SLE patients. The findings highlight the need for routine audiological assessments, including PTA and High Frequency Audiometry (HFA), in the management of SLE patients to facilitate early detection and treatment of hearing loss.

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“…Patients with involved carotid and vertebral arteries may present with stroke, visual loss, or clinical manifestations associated with transient ischaemic stroke (TIA) such as syncope, dizziness or headache (8). Increased frequency of hearing loss has been reported in autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis and various other inflammatory disorders including small vessel vasculitis (9)(10)(11)(12)(13). We had observed patients presenting with acute or chronic hearing loss, of specifically sensorineural type, among patients with TAK, however to the best of our knowledge there were no data in the literature supporting our observations.…”

Section: Introductionmentioning

confidence: 99%

Hearing loss in Takayasu's arteritis

Kimyon,

Gözen,

Karaman

et al. 2023

Clinical and Experimental Rheumatology

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ObjectiveNeurosensory hearing loss is well-documented in chronic autoimmune conditions such as systemic lupus erythematosus (SLE). However, the literature lacks data on the prevalence and characteristics of hearing impairment in Takayasu's arteritis (TAK). In this cross-sectional study, our principal objective was to systematically assess the auditory function of individuals diagnosed with TAK, against SLE patients and healthy controls (HC). MethodAge and gender matched TAK and SLE patients followed up in a tertiary centre along with healthy controls were included in a two-phase study. In the first phase, a questionnaire on ENT symptoms was administered to the patient (TAK: n=104 and SLE: n= 151) and HC (n=174) groups. In the second phase, patients (TAK: n=53 and SLE: n=33) and HC (n=45) underwent audiometric tests. ResultsThe questionnaire survey revealed that both TAK and SLE patients reported hearing loss (27.9%, 25.8%, 7.4%, p<0.001), tinnitus (49%, 35.8%, 13.8%, p<0.001) and vertigo (46.2%, 33.8%, 16.7%, p<0.001) at significantly higher rates than HC. Audiometry results indicated that both TAK (30.2%) and SLE patients (18.2%) had increased hearing loss compared to HC (8.9%), however, only TAK patients were found to have significantly increased risk in age adjusted logistic regression analysis (OR= 3.915, p=0.026). Hearing loss was mainly neurosensory in all groups. TAK patients were affected at both low (<6000 Hz) and high (>6000 Hz) frequencies, whereas SLE patients were affected only at high frequencies. Hearing loss was significantly associated only with older age. No association was observed with the anatomical location of vascular involvement or history of stroke. ConclusionOur study reveals an increased prevalence of hearing loss in TAK. Further research is crucial to uncover the underlying causes.

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Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Cited by 6 publications

References 28 publications

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4⁺T-cell migration in SLE

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4⁺T-cell migration in SLE

Prevalence of Hearing Impairment Among Systemic Lupus Erythematosus Patients

Hearing loss in Takayasu's arteritis

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Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Cited by 6 publications

References 28 publications

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4+T-cell migration in SLE

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4+T-cell migration in SLE

Prevalence of Hearing Impairment Among Systemic Lupus Erythematosus Patients

Hearing loss in Takayasu's arteritis

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Product

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Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4⁺T-cell migration in SLE

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4⁺T-cell migration in SLE