Eantiospecific Synthesis of Chiral Pyrrolidine‐fused Piperazine Derivatives via Diaza‐Cope Rearrangement

Synthesis of Triazolo- and Oxadiazolopiperazines by Gold(I)-Catalyzed Domino Cyclization: Application to the Design of a Mitogen Activated Protein (MAP) Kinase Inhibitor

“…There have also been a number of applications of fused piperazine scaffolds as enzyme inhibitors and receptor ligands including a p38α kinase inhibitor, poly­(ADP-ribose) polymerase (PARP) inhibitors, and histone deacetylase (HDAC) inhibitors . For these medicinal chemistry investigations, a variety of synthetic approaches for obtaining fused piperazine scaffolds have been developed …”