EA-D p45-IgG as a Potential Biomarker for Nasopharyngeal Carcinoma Diagnosis

Chen, Hao; Luo, Yun; Zhang, Lin; Tian, Lizhen; Feng, Z K; Liu, Wanli

doi:10.7314/apjcp.2013.14.12.7433

Cited by 10 publications

(6 citation statements)

References 24 publications

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“…Similarly, our results showed that only 24 of 601 patients (4.0%) had abnormally high S-ALP with a diagnostic accuracy for NPC much less than other useful serum biomarkers (Chen et al, 2013) , confirming that S-ALP is unsuitable for diagnosis or screening of this tumor. Instead, our results show that the value of S-ALP lies in predicting prognosis.…”

Section: Discussionsupporting

confidence: 63%

Prognostic Value of Pretreatment Serum Alkaline Phosphatase in Nasopharyngeal Carcinoma

Xie¹,

Wei²,

Xu-wei³

2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 63%

Prognostic Value of Pretreatment Serum Alkaline Phosphatase in Nasopharyngeal Carcinoma

Xie¹,

Wei²,

Xu-wei³

2014

Asian Pacific Journal of Cancer Prevention

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“…Statistically significant differences were observed by Chen et al [30] in the scores/levels of six markers (EVB-IgG, VCA-IgG, EA-D p43-IgG, EA-IgG, EA-IgG + EBNA1-IgG, and EA-D p45-IgG) between NPC patients and healthy subjects. The lytic cycle of EBV is important and plays more active roles in oncogenesis [31].…”

Section: Discussionmentioning

confidence: 95%

Serum EBV antibodies and LMP-1 in Polish patients with oropharyngeal and laryngeal cancer

Fołtyn

Strycharz-Dudziak

Drop

et al. 2017

Infect Agents Cancer

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BackgroundThe association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polish patients with oropharyngeal and laryngeal cancer compared to 40 healthy individuals.MethodsFrozen tumor tissue fragments were tested using nested PCR assay for EBV DNA detection. Sera from all individuals were investigated using ELISA tests to detect the presence of VCA IgM and IgG, EBNA IgG, EA IgG.ResultsEBV DNA was detected in 52.7% of the patients (25% in controls). EBVCA were detected in 94.5%, EBNA in 96.4% and EA in 94.5% of patients. The significantly higher level of EA in the patients suggests EBV reactivation. The majority of patients (83%) were infected with wild-type EBV.ConclusionOur study showed that this variant seems to be associated with oropharyngeal and laryngeal cancer in the Polish population.

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“…EBV latencyassociated gene expression is consistently detected in NPC tumor cells and is regarded therefore as one of the factors in the oncogenesis (Raab-Traub, 2002;Burgos, 2005). Although viral expression in NPC cells is largely restricted to EBV nuclear antigen-1 (EBNA1) and latent 1 , Min-Zhong Tang 1,4 * membrane protein-1 (LMP1), and LMP2A (Burgos, 2005;Hariwiyanto et al, 2010), transcription of a large variety of viral genes including those associated with EBV replication cycle was detected (Zhang et al, 1998;Xue et al, 2000;Walling et al, 2001;Chen et al, 2013). In situ studies identified lytic EBV antigens in nonmalignant epithelial cells (Tao et al, 1995) and infiltrating lymphoid cells (Wen et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Significance of Combined Detection of Epstein-Barr Virus Antibodies, VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA for Nasopharyngeal Carcinoma

Cai

Li²,

Lu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The objective of this study was to investigate the diagnostic significance of EBV antibody combined detection for nasopharyngeal carcinoma (NPC) in a high incidence region of southern China. Two hundred and eleven untreated NPC patients, 203 non-NPC ENT patients, and 210 healthy controls were recruited for the study. The titers of VCA/IgA and EA/IgA were assessed by immunoenzyme assay, and the levels of Rta/IgG and EBNA1/IgA were determined by enzyme-linked immunosorbent assay. The levels of VCA/IgA, EA/IgA, Rta/IgG and EBNA1/ IgA demonstrated no association with gender or age (p>0.05). The receiver operating characteristic curve and the area under the curve were used to evaluate the diagnostic value. The sensitivity of VCA/IgA (98.1%) and the specificity of EA/IgA (98.5%) were the highest. When a logistic regression model was used to combine the results from multiple antibodies to increase the accuracy, the combination of VCA/IgA+Rta/IgG, whose area under the curve was 0.99, had the highest diagnostic efficiency, and its sensitivity, specificity and Youden index were 94.8%, 98.0% and 0.93 respectively. The data suggest that the combination of VCA/IgA+Rta/IgG may be most suitable for NPC serodiagnosis.

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EA-D p45-IgG as a Potential Biomarker for Nasopharyngeal Carcinoma Diagnosis

Cited by 10 publications

References 24 publications

Prognostic Value of Pretreatment Serum Alkaline Phosphatase in Nasopharyngeal Carcinoma

Prognostic Value of Pretreatment Serum Alkaline Phosphatase in Nasopharyngeal Carcinoma

Serum EBV antibodies and LMP-1 in Polish patients with oropharyngeal and laryngeal cancer

Diagnostic Significance of Combined Detection of Epstein-Barr Virus Antibodies, VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA for Nasopharyngeal Carcinoma

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