Prognostic Value of Pretreatment Serum Alkaline Phosphatase in Nasopharyngeal Carcinoma

Xie, Ying; Wei, Zhengbo; Xu-wei, Duan

doi:10.7314/apjcp.2014.15.8.3547

Cited by 21 publications

(20 citation statements)

References 30 publications

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“…According to previously studies, in some kinds of cancer, the elevation of ALP or LDH might indicate a heavy tumor burden and tumor metastasis. High ALP level was reported to be related with worse prognosis in colorectal cancer 7, nasopharyngeal carcinoma 8, prostate cancer9, and esophageal squamous cell carcinoma10. Serum LDH level was demonstrated to be a prognostic factor in nasopharyngeal carcinoma11, lymphoma12, small cell lung cancer13, myeloma14 and prostate cancer15.…”

Section: Introductionmentioning

confidence: 99%

Pre-treatment serum alkaline phosphatase and lactate dehydrogenase as prognostic factors in triple negative breast cancer

Chen¹,

Dai²,

Tang³

et al. 2016

J. Cancer

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Background: Serum parameters as prognostic parameters are studied widely. We aim to examine the prognostic significance of the serum alkaline phosphatase (ALP) level and lactate dehydrogenase (LDH) level in triple negative breast cancer (TNBC).Methods: Total of 253 TNBC patients from Sun Yat-sen University Cancer Center who underwent treatment between January 2004 and December 2009 was conducted in this retrospective study. Before treatment serum ALP and LDH levels were routinely measured. We use the receiver operating characteristic (ROC) curve analysis to estimate the cutoff value of serum ALP and LDH levels. The Kaplan-Meier method and multivariable Cox regression analysis were used for Disease free survival (DFS) and overall survival (OS) assessed.Results: The ROC curves determined that the optimum cutoff point for ALP and LDH were 66.5u/L and 160.5u/L, respectively. The elevated ALP and LDH were both significantly associated with decreased DFS and OS (both P < 0.001). In addition, the entire cohort was stratified into three subgroups basis of ALP levels and LDH levels. TNBC Patients who with ALP >66.5 u/L and LDH >160.5u/L had the worst DFS and OS (both P < 0.001). In TNBC patients, univariate and multivariate Cox regression analyses conformed ALP and LDH were independent unfavorable prognostic factors for DFS and OS.Conclusions: The serum levels of ALP and LDH before treatment are independent prognostic parameters and may serve as complement to help predict survival in TNBC.

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Section: Introductionmentioning

confidence: 99%

Pre-treatment serum alkaline phosphatase and lactate dehydrogenase as prognostic factors in triple negative breast cancer

Chen¹,

Dai²,

Tang³

et al. 2016

J. Cancer

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“…With respect to cancer, ALT was recently supposed to be a poor survival indicator in prostate cancer, nasopharyngeal cancer and colorectal cancer (Saif et al, 2005;Sonpavde et al, 2012;Xie et al, 2014). In addition, ALP has also been included in the Chinese University Prognostic Index, an liver cancer staging system that assigns a score of 3 when ALP is >200 IU/L (Leung et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Model Based on Alkaline Phosphatase and Gamma-Glutamyltransferase for Gallbladder Cancer Prognosis

Xu¹,

Miao²,

Zhang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…NPC is generally only diagnosed at advanced stages of cancer progression because of its location deep inside the head and its vague symptoms which leading to poor prognosis and low survival rate of patients (Xie et al, 2014). Hence, it is very importance to find biomarker for early diagnosis of NPC.…”

Section: Discussionmentioning

confidence: 99%

RASSF1A Gene Methylation is Associated with Nasopharyngeal Carcinoma Risk in Chinese

Xu²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups , similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.

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Prognostic Value of Pretreatment Serum Alkaline Phosphatase in Nasopharyngeal Carcinoma

Cited by 21 publications

References 30 publications

Pre-treatment serum alkaline phosphatase and lactate dehydrogenase as prognostic factors in triple negative breast cancer

Pre-treatment serum alkaline phosphatase and lactate dehydrogenase as prognostic factors in triple negative breast cancer

Model Based on Alkaline Phosphatase and Gamma-Glutamyltransferase for Gallbladder Cancer Prognosis

RASSF1A Gene Methylation is Associated with Nasopharyngeal Carcinoma Risk in Chinese

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