E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia

Parriott, Geoffrey; Kee, Barbara L.

doi:10.3389/fimmu.2022.885144

Cited by 7 publications

(3 citation statements)

References 133 publications

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“…These intricate interactions highlight the complex regulatory network involved in T-ALL and the contribution of the TAL1-miR223 axis to disease progression. 47 The abnormal upregulation of miR-223, which is mediated by TAL1, is a critical process that enhances the growth of T-ALL cells that are positive for TAL1. The miR-223 expression sustains some T-ALL cells even after TAL1 knockdown.…”

Section: Mir-223mentioning

confidence: 99%

Involvement of TAL1-microRNA Axis in the Progression of T-cell Acute Lymphoblastic Leukemia

Purrahman,

Yousefi,

Shojaeian

et al. 2024

Gene Expr

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The T-cell acute lymphoblastic leukemia 1 (TAL-1) transcription factor is crucial for T-cell differentiation, but the ectopic expression in 30% of cases can disrupt normal differentiation, and promote cancer progression. This can be due to microRNA (miRNA) dysregulation or other oncogenes. The present study covers articles related to T-cell acute lymphoblastic leukemia (T-ALL), TAL-1 and miRNA, which were published in the English language from 1994 to 2023. After analyzing the research, it is evident that the TAL-1 overexpression is associated with alterations in several miRNAs, which encompass both those that suppress tumors, and those that stimulate cell growth. The interplay between TAL-1 and miRNAs exhibits diverse dynamics. For example, specific miRNAs, such as miR-223, interact with the TAL-1 gene promoter, resulting in its upregulation. In contrast, the miR-17-92 cluster indirectly influences the stability of the TAL-1 transcription complex. Typically, the interaction between TAL-1 and its associated miRNAs follows a unidirectional pattern, in which miRNAs that target TAL-1 are downregulated, leading to elevated TAL-1 levels. Nevertheless, TAL-1 exhibits a bidirectional relationship with miR-223, in which each positively affects the expression of the other. In addition, there is a cooperative interaction between miR-146-5b and TAL-1. Unlike miR-223, TAL-1 reduces the expression of miR-146-5b, thereby inhibiting tumor growth. Individuals with T-ALL, who experience disruptions in the TAL-1 and miRNA network, often face a poor prognosis, and their tumors tend to be larger. In conclusion, delving deeper into the network of miRNAs associated with TAL-1 in T-ALL offers a novel perspective on cancer prognosis and the development of improved diagnostic and treatment strategies.

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Section: Mir-223mentioning

confidence: 99%

Involvement of TAL1-microRNA Axis in the Progression of T-cell Acute Lymphoblastic Leukemia

Purrahman,

Yousefi,

Shojaeian

et al. 2024

Gene Expr

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“…E2A/HEB double knockout mice and E2A/LAT double knockout mice (transgenic mice unable to signal through TCRβ) display hypercellularity in the thymus, because of aberrant proliferation of DN3 cells which cannot maintain cell cycle arrest ( 159 , 279 ). Hence, E protein-deficient mice are highly susceptible to T-cell lymphoma ( 149 , 280 ).…”

Section: Gene Regulatory Network Models For Early T Cell Development ...mentioning

confidence: 99%

Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells

Shin

Rothenberg

2023

Front. Immunol.

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T cells develop from multipotent progenitors by a gradual process dependent on intrathymic Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell lineage commitment are well characterized by single-cell and bulk RNA analyses of sorted populations and by direct measurements of precursor-product relationships. This process depends not only on Notch signaling but also on multiple transcription factors, some associated with stemness and multipotency, some with alternative lineages, and others associated with T-cell fate. These factors interact in opposing or semi-independent T cell gene regulatory network (GRN) subcircuits that are increasingly well defined. A newly comprehensive picture of this network has emerged. Importantly, because key factors in the GRN can bind to markedly different genomic sites at one stage than they do at other stages, the genes they significantly regulate are also stage-specific. Global transcriptome analyses of perturbations have revealed an underlying modular structure to the T-cell commitment GRN, separating decisions to lose “stem-ness” from decisions to block alternative fates. Finally, the updated network sheds light on the intimate relationship between the T-cell program, which depends on the thymus, and the innate lymphoid cell (ILC) program, which does not.

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“…Acute lymphoblastic leukemia (ALL) is a malignancy derived from B/T cell lineage lymphatic progenitor cells during the transformation of B/T lymphocytes ( 138 , 139 ). It is the most common malignancy of childhood and mainly develops in children aged 2–5 years ( 140 ).…”

Section: The Roles Of Raman Spectroscopy In Pediatric Cancermentioning

confidence: 99%

The emerging applications and advancements of Raman spectroscopy in pediatric cancers

Feng²,

Xu³

et al. 2023

Front. Oncol.

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Although the survival rate of pediatric cancer has significantly improved, it is still an important cause of death among children. New technologies have been developed to improve the diagnosis, treatment, and prognosis of pediatric cancers. Raman spectroscopy (RS) is a non-destructive analytical technique that uses different frequencies of scattering light to characterize biological specimens. It can provide information on biological components, activities, and molecular structures. This review summarizes studies on the potential of RS in pediatric cancers. Currently, studies on the application of RS in pediatric cancers mainly focus on early diagnosis, prognosis prediction, and treatment improvement. The results of these studies showed high accuracy and specificity. In addition, the combination of RS and deep learning is discussed as a future application of RS in pediatric cancer. Studies applying RS in pediatric cancer illustrated good prospects. This review collected and analyzed the potential clinical applications of RS in pediatric cancers.

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E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia

Cited by 7 publications

References 133 publications

Involvement of TAL1-microRNA Axis in the Progression of T-cell Acute Lymphoblastic Leukemia

Involvement of TAL1-microRNA Axis in the Progression of T-cell Acute Lymphoblastic Leukemia

Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells

The emerging applications and advancements of Raman spectroscopy in pediatric cancers

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