E-jet 3D printed drug delivery implants to inhibit growth and metastasis of orthotopic breast cancer

Yang, Yikun; Qiao, Xiaoyin; Huang, Ruiying; Chen, Haoxiang; Shi, Xuelei; Wang, Jian; Tan, Weihong; Tan, Zhikai

doi:10.1016/j.biomaterials.2019.119618

Cited by 67 publications

(37 citation statements)

References 59 publications

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“…Degradation assessment was performed as reported elsewhere [22] in a static immersion of the samples simulating two physiological conditions such as pH by using a Hartmann solution (pH = 7.4) and temperature at 37 • C using a custom incubator controlled by a PDI-TC4S Temperature Controller (Autonics Corporation LTD., Busan, Korea). For the evaluation, a pre-weighed 0.5 cm 2 standardized PU-INU film was soaked in the solution and left at 37 • C on the incubator and in order to determinate the degradation rate (D r ) at determinate elapsed times, it was represented in terms of weight loss (difference between initial and final weight of the samples) and calculated using a first order decay exponential differential Equation (2):…”

Section: Physical Properties Characterizationmentioning

confidence: 99%

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

et al. 2020

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In this study, new polyurethanes (PUs) were prepared by using inulin and polycaprolactone as polyols. Their structure and morphology were determined by Fourier transform infrared spectroscopy (FTIR), Raman dispersive spectroscopy, Nuclear magnetic resonance spectroscopy ( 1 H NMR and 13 C NMR), and scanning electron microscopy (SEM), whereas their mechanical properties were evaluated by a universal testing machine. Additionally, their water uptake, swelling behavior, and degradation were evaluated to be used as drug delivery carriers. Therefore, an anti-cancer drug was loaded to these PUs with 25% of loading efficiency and its release behavior was studied using different theoretical models to unveil its mechanism. Finally, the ability of the new PUs to be used as a clip marker in breast biopsy was evaluated. The results clearly demonstrate that these PUs are safe and can be used as intelligent drug release matrices for targeted drug delivery and exhibits positive results to be used for clip marker and in general for breast cancer applications.

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Section: Physical Properties Characterizationmentioning

confidence: 99%

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

et al. 2020

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“…Aside from controlled drug delivery systems which require injection to the tumor area, implant-based controlled drug delivery systems, have the advantage of providing a controlled but also localized delivery of the drug and can minimize systemic toxicity. Electrospun PLGA scaffolds, 3D printed PLGA, carbon nanotubes, and mesoporous silica nanoparticles have been used to encapsulate therapeutic agents to be used in implantable controlled drug delivery systems [29,37,38]. Of such methods, the distinguishing property of the electropsun scaffolds, is their ability to be tuned and provide various release kinetics of the drug, depending on the selection of the polymer used to fabricate the scaffold [39].…”

Section: Discussionmentioning

confidence: 99%

“…This will eliminate the need to inject the drug in multiple times to keep the therapeutic concentration, which provides patient comfort and reduces toxicity potential. Specifically, in case of cancer treatment, drug-loaded implants not only provide a local and efficient delivery but also minimize the systemic toxicity [29]. Likewise, local delivery of Honokiol using electrospun scaffolds for RCC treatment, would eliminate the potential toxicity problems associated with direct injection.…”

Section: Introductionmentioning

confidence: 99%

Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells

et al. 2020

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Renal Cell Carcinoma (RCC) often becomes resistant to targeted therapies, and in addition, dose-dependent toxicities limit the effectiveness of therapeutic agents. Therefore, identifying novel drug delivery approaches to achieve optimal dosing of therapeutic agents can be beneficial in managing toxicities and to attain optimal therapeutic effects. Previously, we have demonstrated that Honokiol, a natural compound with potent anti-tumorigenic and anti-inflammatory effects, can induce cancer cell apoptosis and inhibit the growth of renal tumors in vivo. In cancer treatment, implant-based drug delivery systems can be used for gradual and sustained delivery of therapeutic agents like Honokiol to minimize systemic toxicity. Electrospun polymeric fibrous scaffolds are ideal candidates to be used as drug implants due to their favorable morphological properties such as high surface to volume ratio, flexibility and ease of fabrication. In this study, we fabricated Honokiol-loaded Poly(lactide-co-glycolide) (PLGA) electrospun scaffolds; and evaluated their structural characterization and biological activity. Proton nuclear magnetic resonance data proved the existence of Honokiol in the drug loaded polymeric scaffolds. The release kinetics showed that only 24% of the loaded Honokiol were released in 24hr, suggesting that sustained delivery of Honokiol is feasible. We calculated the cumulative concentration of the Honokiol released from the scaffold in 24hr; and the extent of renal cancer cell apoptosis induced with the released Honokiol is similar to an equivalent concentration of direct application of Honokiol. Also, Honokiol-loaded scaffolds placed directly in renal cell culture inhibited renal cancer cell proliferation and migration. Together, we demonstrate that Honokiol delivered through electrospun PLGA-based scaffolds is effective in inhibiting the growth of renal cancer cells; and our data necessitates further in vivo studies to explore the potential of sustained release of therapeutic agents-loaded electrospun scaffolds in the treatment of RCC and other cancer types.

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“…The authors found that the scaffolds had a relatively slow sustained chemotherapist release and a good antitumor efficacy over a relatively long period. The use of porous scaffolds as local drug reservoirs to prevent cancer recurrence and stimulate new tissue regeneration was also suitable for soft tissues applications, such as breast cancer therapy ( Dang et al, 2020 ; Yang et al, 2020 ). AM and salt-leaching techniques were combined to produce bimodal porous PCL scaffolds that were subsequently loaded with doxorubicin by the wet dipping method.…”

Section: Recent Applications Of Computer-aided Design Drug Delivery Platforms For Cancer Treatmentmentioning

confidence: 99%

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Salerno¹,

Netti

2021

Front. Bioeng. Biotechnol.

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In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs.

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E-jet 3D printed drug delivery implants to inhibit growth and metastasis of orthotopic breast cancer

Cited by 67 publications

References 59 publications

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

Synthesis and Characterization of Inulin-Based Responsive Polyurethanes for Breast Cancer Applications

Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

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