E-Cadherin Expression in Relation to Clinicopathological Parameters and Survival of Patients with Epithelial Ovarian Cancer

Kiełbik, Michał; Szulc-Kiełbik, Izabela; Klink, Magdalena

doi:10.3390/ijms232214383

Cited by 6 publications

(4 citation statements)

References 77 publications

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“…E-cadherin binds to actin microfilaments in the cytoplasm via α-and βcatenin, thereby promoting attachment of epithelial cells to each other. In general, the loss of E-cadherin in ovarian cancer correlates with epithelialmesenchymal transformation, contributing to invasion [15].…”

Section: Figure 2 -The Results Of Visualization Of the Number Of Scie...mentioning

confidence: 99%

Metastatic Ovarian Cancer: Bibliographic Analysis

Piddubnyi,

Tkachenko,

Shubin

et al. 2023

EUMJ

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Introduction. Ovarian cancer is an oncogynecological disease with high mortality. High mortality caused by this pathology is associated with diagnosis at the III–IV stage of the disease. This stage of the disease is characterized by metastasis and reflected in the 5-year survival rate, decreasing to 30.2 %. At the same time, when diagnosed at the I-II stage, this indicator is 92.6%. The aim of the work is bibliometric analysis and generalization of data from scientific sources on the study of ovarian cancer metastasis. Materials and methods. Information was searched on electronic resources of the Scopus, Web of Science, PubMed, and Google Scholar databases using the keywords "ovarian cancer" and "metastases." An online platform for monitoring and analyzing scientific sources was used for bibliometric analysis. We used several VOSviewer bibliometric network visualization system tools and SciVal (Scopus) modern citation requirements. Results. It has been established that metastasis of ovarian cancer can occur in several ways and depends on the conditions of the tumor microenvironment. The influence of E-cadherin, MMP-2, and transglutaminase-2 on metastasis processes was evaluated. Also, the role of cytokines in the invasiveness of the tumor process and metastasis was established. The results of bibliometric analysis of scientific sources showed that over the past 20 years, the number of publications on ovarian cancer metastasis has increased significantly, and the most widely given topic is studied in the USA and China. Conclusions. Metastasis of ovarian cancer can occur in several ways and depends on the conditions of the tumor microenvironment. It was found that among the analyzed 496 publications, the most relevant directions are molecular-biological and signaling pathways, which are described in many ways in scientific sources on ovarian cancer metastasis. The calcification of peritoneal metastases and their formation mechanism are currently not investigated, and there is no thorough explanation that may become a perspective for further research.

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Section: Figure 2 -The Results Of Visualization Of the Number Of Scie...mentioning

confidence: 99%

Metastatic Ovarian Cancer: Bibliographic Analysis

Piddubnyi,

Tkachenko,

Shubin

et al. 2023

EUMJ

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“…E-cadherin is a calcium-dependent transmembrane glycoprotein that serves as an adhesion molecule belonging to the superfamily of cadherins. It also provides homotypic cell-to-cell interplay [16]. E-cadherin's cytoplasmic tail contains a β-catenin binding domain attached to β-catenin, forming a complex that helps epithelial cell integrity and cell-to-cell adhesion [17].…”

Section: Discussionmentioning

confidence: 99%

Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway

Aljohani,

Khodier,

Al-Gayyar

2023

Cureus

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BackgroundEhrlich solid carcinoma (ESC) is characterized by rapid proliferation and a short survival time. Because Ehrlich ascites carcinoma (EAC) resembles human cancer cells, Ehrlich solid and ascetic forms are commonly used to determine the anticancer effects of various compounds. Luteolin is a flavonoid compound found in many dietary sources, including carrots, peppers, celery, olive oil, peppermint, and oregano. Luteolin has potent anti-inflammatory, antidiabetic, antitumor, and antiapoptotic activities. AimsThis study aims to investigate the antitumor activity of luteolin against ESC in rats by affecting the Wnt/βcatenin/SMAD4 pathway. MethodsWe introduced 0.15 ml of Ehrlich cells (2 × 10 6 ) ESC into the left hind thighs of rats. After eight days of inoculation, the rats orally received 25 mg/kg of luteolin daily. We stained sections of tumor tissues with Masson's trichrome. We used another part of the tumor tissue to assess gene and protein expression of Wnt, β-catenin, E-cadherin, and SMAD4. ResultsTreatment of carcinoma rats with luteolin increased the mean survival time and reduced tumor volume and weight. In addition, examination of tumor tissue stained with Masson's trichrome showed loosely to densely packed collagen fibers in between neoplastic cells and scattered papillary expansion of a loose blue band of collagen expression along the covering adipose connective tissue and extending in a fine strand in between muscle fibers, which was ameliorated by treating rats with luteolin. Finally, treating ESC in rats with luteolin overexpressed E-cadherin and downregulated Wnt, β-catenin, and SMAD4. ConclusionsWe found luteolin has antineoplastic activity against ESC by reducing tumor size and weight while improving the structure of muscle cells. It works by suppressing Wnt, β-catenin, and SMAD4, resulting in decreased tumor cell proliferation and differentiation. Additionally, luteolin overexpresses E-cadherin, leading to reduced tumor cell invasion and metastasis.

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“…Epigenetic regulators play an important role in the expression of E-cadherin and the epigenetic silencing of E-cadherin expression is a highly complex process. Multiple transcription factors and histone-modifying enzymes can negatively modulate E-cadherin transcripts by binding to the E-box elements of its promoter [84]. The nucleosome-remodeling and deacetylase (NuRD) complex plays important roles in the regulation of E-cadherin in multiple tumors including hepatocellular carcinoma and pancreatic cancer.…”

Section: The Underlying Mechanism Of Histone Deacetylases In Regulati...mentioning

confidence: 99%

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

Xu,

Yan,

Wang

et al. 2023

IJMS

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Ovarian cancer is the most lethal gynecologic malignancy, and metastasis is the major cause of death in patients with ovarian cancer, which is regulated by the coordinated interplay of genetic and epigenetic mechanisms. Histone deacetylases (HDACs) are enzymes that can catalyze the deacetylation of histone and some non-histone proteins and that are involved in the regulation of a variety of biological processes via the regulation of gene transcription and the functions of non-histone proteins such as transcription factors and enzymes. Aberrant expressions of HDACs are common in ovarian cancer. Many studies have found that HDACs are involved in regulating a variety of events associated with ovarian cancer metastasis, including cell migration, invasion, and the epithelial–mesenchymal transformation. Herein, we provide a brief overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. In addition, we discuss the roles of HDACs in the regulation of ovarian cancer metastasis. Finally, we discuss the development of compounds that target HDACs and highlight their importance in the future of ovarian cancer therapy.

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E-Cadherin Expression in Relation to Clinicopathological Parameters and Survival of Patients with Epithelial Ovarian Cancer

Cited by 6 publications

References 77 publications

Metastatic Ovarian Cancer: Bibliographic Analysis

Metastatic Ovarian Cancer: Bibliographic Analysis

Antitumor Activity of Luteolin Against Ehrlich Solid Carcinoma in Rats via Blocking Wnt/β-Catenin/SMAD4 Pathway

The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis

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